DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shmt and SHM7

DIOPT Version :9

Sequence 1:	NP_572278.1	Gene:	Shmt / 31524	FlyBaseID:	FBgn0029823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_564473.1	Gene:	SHM7 / 840543	AraportID:	AT1G36370	Length:	598	Species:	Arabidopsis thaliana

Alignment Length:	478	Identity:	237/478 - (49%)
Similarity:	314/478 - (65%)	Gaps:	17/478 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DSKQSTLKNMADQKLLQTPLAQGDPELAELIKKEKERQREGLEMIASENFTSVAVLESLSSCLTN 126
            :|:::.::...||     |:...||::.||::|||:||..|:|:||||||...||:|:|.|.|||
plant   124 ESRRAAVRAWGDQ-----PIHLADPDIHELMEKEKQRQVRGIELIASENFVCRAVMEALGSHLTN 183

  Fly   127 KYSEGYPGKRYYGGNEYIDRIELLAQQRGRELFNLDDEKWGVNVQPYSGSPANLAVYTGVCRPHD 191
            |||||.||.|||.||:|||:||.|..:|....|.|:.:||||||||||.:.||.|||||:..|.:
plant   184 KYSEGMPGARYYTGNQYIDQIENLCIERALTAFGLESDKWGVNVQPYSCTSANFAVYTGLLLPGE 248

  Fly   192 RIMGLDLPDGGHLTHGFFTP-TKKISATSIFFESMPYKVNPETGIIDYDKLAEAAKNFRPQIIIA 255
            ||||||.|.|||::||:.|| .|||||.||||||.||||||:||.||||||.:.|.::||:|:|.
plant   249 RIMGLDSPSGGHMSHGYCTPGGKKISAASIFFESFPYKVNPQTGYIDYDKLEDKALDYRPKILIC 313

  Fly   256 GISCYSRLLDYARFRQICDDVGAYLMADMAHVAGIVAAGLIPSPFEWADIVTTTTHKTLRGPRAG 320
            |.|.|.|..|:||.|||.|..||.||.||||::|:||.....:||:..||||:||||.|||||.|
plant   314 GGSSYPRDWDFARVRQIADKCGAVLMCDMAHISGLVATKECSNPFDHCDIVTSTTHKGLRGPRGG 378

  Fly   321 VIFFRKGVRSTKAN------GDKVLYDLEERINQAVFPSLQGGPHNNAVAGIATAFKQAKSPEFK 379
            :||:|:|.:..|..      .....|||||:||.|||||||||||||.:|.:|.|.||..:||:|
plant   379 IIFYRRGPKIRKQGHHSSHCDTSTHYDLEEKINFAVFPSLQGGPHNNHIAALAIALKQVATPEYK 443

  Fly   380 AYQTQVLKNAKALCDGLISRGYQVATGGTDVHLVLVDVRKAGLTGAKAEYILEEVGIACNKNTVP 444
            ||..|:.|||:||...|:.|..::.|||||.||:|.|:...||||...|.:.|...|..||..:.
plant   444 AYIQQMKKNAQALAAALLRRKCRLVTGGTDNHLLLWDLTPMGLTGKVYEKVCEMCHITLNKTAIF 508

  Fly   445 GDKSAMNPSGIRLGTPALTTRGLAEQDIEQVVAFIDAALKVGVQAAKLAGSPKITDYHKTLAENV 509
            ||...::|.|:|:||||:||||..|.|.|.:..|:..|.::.....:..|..     ||...:::
plant   509 GDNGTISPGGVRIGTPAMTTRGCIESDFETMADFLIKAAQITSALQREHGKS-----HKEFVKSL 568

  Fly   510 ELKAQVDEIRKNVAQFSRKFPLP 532
            .....:.|:|..|..|:.::.:|
plant   569 CTNKDIAELRNRVEAFALQYEMP 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shmt	NP_572278.1	PLN03226	79..536	CDD:215639	234/461 (51%)
Shmt	NP_572278.1	SHMT	82..493	CDD:99733	225/417 (54%)
SHM7	NP_564473.1	PLN02271	3..595	CDD:215153	237/478 (50%)
SHM7	NP_564473.1	AAT_I	141..543	CDD:302748	223/401 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60631
OrthoDB	1	1.010	-	-		D372408at2759
OrthoFinder	1	1.000	-	-		FOG0000859
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100262
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X557
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.690