DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shmt and SHM2

DIOPT Version :9

Sequence 1:	NP_572278.1	Gene:	Shmt / 31524	FlyBaseID:	FBgn0029823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_568488.2	Gene:	SHM2 / 832736	AraportID:	AT5G26780	Length:	533	Species:	Arabidopsis thaliana

Alignment Length:	534	Identity:	263/534 - (49%)
Similarity:	369/534 - (69%)	Gaps:	30/534 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RDLNTKVGNPVNFETGKLSGALTRIAAKKQPSPTPFLPAIRRYSDSKQSTLKNMADQKLLQTPLA 82
            |.|::.|..|::..:.  :|...|..:....:      |:.....|:.|.:|.      |...|.
plant     6 RRLSSSVKKPISLLSS--NGGSLRFMSSLSTA------AMAESEKSRSSWIKQ------LNASLD 56

  Fly    83 QGDPELAELIKKEKERQREGLEMIASENFTSVAVLESLSSCLTNKYSEGYPGKRYYGGNEYIDRI 147
            :.|||:|::|:.||.||.:|.|:|.||||||::|::::.|.:||||||||||.||||||||||..
plant    57 EIDPEVADIIELEKARQWKGFELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMA 121

  Fly   148 ELLAQQRGRELFNLDDEKWGVNVQPYSGSPANLAVYTGVCRPHDRIMGLDLPDGGHLTHGFFTPT 212
            |.|.|:|..|.|.||..|||||||..||||||..|||.:.:||:|||.||||.||||:||:.|.|
plant   122 ETLCQKRALEAFQLDPSKWGVNVQSLSGSPANFQVYTALLKPHERIMALDLPHGGHLSHGYQTDT 186

  Fly   213 KKISATSIFFESMPYKVNPETGIIDYDKLAEAAKNFRPQIIIAGISCYSRLLDYARFRQICDDVG 277
            |||||.|||||:|||:::..||.||||:|.::|..|||::|:||.|.|:||.||||.|::|:...
plant   187 KKISAVSIFFETMPYRLDENTGYIDYDQLEKSAVLFRPKLIVAGASAYARLYDYARIRKVCNKQK 251

  Fly   278 AYLMADMAHVAGIVAAGLIPSPFEWADIVTTTTHKTLRGPRAGVIFFRKGVRSTKANGDKVLYDL 342
            |.::|||||::|:||||:||||||:||:|||||||:|||||..:||||||::.....|.:|:||.
plant   252 AVMLADMAHISGLVAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGLKEINKQGKEVMYDY 316

  Fly   343 EERINQAVFPSLQGGPHNNAVAGIATAFKQAKSPEFKAYQTQVLKNAKALCD------------- 394
            |:||||||||.|||||||:.:.|:|.|.|||::||:||||.|||:|.....:
plant   317 EDRINQAVFPGLQGGPHNHTITGLAVALKQARTPEYKAYQDQVLRNCSKFAELDIRPTVIISYGL 381

  Fly   395 ---GLISRGYQVATGGTDVHLVLVDVRKAGLTGAKAEYILEEVGIACNKNTVPGDKSAMNPSGIR 456
               .|:::||.:.:||||.|||||:::..|:.|::.|.:||.|.||.||||||||.|||.|.|||
plant   382 SMQTLLAKGYDLVSGGTDNHLVLVNLKNKGIDGSRVEKVLELVHIAANKNTVPGDVSAMVPGGIR 446

  Fly   457 LGTPALTTRGLAEQDIEQVVAFIDAALKVGVQAAKLAGSPKITDYHKTLAENVELKAQVDEIRKN 521
            :||||||:||..|:|..:|..:.|.|:|:.::....:...|:.|:..|:..|.:|::::.::|:.
plant   447 MGTPALTSRGFIEEDFAKVAEYFDLAVKIALKIKAESQGTKLKDFVATMQSNEKLQSEMSKLREM 511

  Fly   522 VAQFSRKFPLPGLE 535
            |.:::::||..|.|
plant   512 VEEYAKQFPTIGFE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shmt	NP_572278.1	PLN03226	79..536	CDD:215639	252/473 (53%)
Shmt	NP_572278.1	SHMT	82..493	CDD:99733	240/426 (56%)
SHM2	NP_568488.2	PLN03226	41..533	CDD:215639	256/491 (52%)
SHM2	NP_568488.2	SHMT	55..468	CDD:278870	238/412 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	509	1.000	Domainoid score	I68
eggNOG	1	0.900	-	-		E1_COG0112
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3074
Inparanoid	1	1.050	545	1.000	Inparanoid score	I260
OMA	1	1.010	-	-		QHG60631
OrthoDB	1	1.010	-	-		D372408at2759
OrthoFinder	1	1.000	-	-		FOG0000859
OrthoInspector	1	1.000	-	-		otm2791
orthoMCL	1	0.900	-	-		OOG6_100262
Panther	1	1.100	-	-	O	PTHR11680
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840