DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shmt and SHMT2

DIOPT Version :9

Sequence 1:	NP_572278.1	Gene:	Shmt / 31524	FlyBaseID:	FBgn0029823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_005403.2	Gene:	SHMT2 / 6472	HGNCID:	10852	Length:	504	Species:	Homo sapiens

Alignment Length:	501	Identity:	285/501 - (56%)
Similarity:	370/501 - (73%)	Gaps:	17/501 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GALTRIAAKKQPSPTPFLPAIRRYSDSKQSTLKNMADQKLLQTPLAQGDPELAELIKKEKERQRE 101
            |.|.|:|.:.|            :|::.|:...........|..|:..|||:.||:::||:||..
Human    17 GQLVRMAIRAQ------------HSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCR 69

  Fly   102 GLEMIASENFTSVAVLESLSSCLTNKYSEGYPGKRYYGGNEYIDRIELLAQQRGRELFNLDDEKW 166
            |||:||||||.|.|.||:|.|||.|||||||||||||||.|.:|.||||.|:|..|.|:||..:|
Human    70 GLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQW 134

  Fly   167 GVNVQPYSGSPANLAVYTGVCRPHDRIMGLDLPDGGHLTHGFFTPTKKISATSIFFESMPYKVNP 231
            ||||||||||||||||||.:.:|||||||||||||||||||:.:..|:||||||||||||||:||
Human   135 GVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNP 199

  Fly   232 ETGIIDYDKLAEAAKNFRPQIIIAGISCYSRLLDYARFRQICDDVGAYLMADMAHVAGIVAAGLI 296
            :||:|||::||..|:.|||::||||.|.|:||:||||.|::||:|.|:|:|||||::|:|||.:|
Human   200 KTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVI 264

  Fly   297 PSPFEWADIVTTTTHKTLRGPRAGVIFFRKGVRST-KANGDKVLYDLEERINQAVFPSLQGGPHN 360
            ||||:.||||||||||||||.|:|:||:||||::. ...|.::.|..|:|||.||||||||||||
Human   265 PSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHN 329

  Fly   361 NAVAGIATAFKQAKSPEFKAYQTQVLKNAKALCDGLISRGYQVATGGTDVHLVLVDVRKAGLTGA 425
            :|:|.:|.|.|||.:|.|:.|..||||||:|:.|.|:.|||.:.:||||.||||||:|..||.||
Human   330 HAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGA 394

  Fly   426 KAEYILEEVGIACNKNTVPGDKSAMNPSGIRLGTPALTTRGLAEQDIEQVVAFIDAALKVGVQA- 489
            :||.:||.|.|..||||.|||:||:.|.|:|||.||||:|...|.|..:||.|||..:.:|::.
Human   395 RAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVK 459

  Fly   490 AKLAGSPKITDYHKTLAENVELKAQVDEIRKNVAQFSRKFPLPGLE 535
            :|.|   |:.|:...|.::.|...::..:|:.|.||:|.||:||.:
Human   460 SKTA---KLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFD 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shmt	NP_572278.1	PLN03226	79..536	CDD:215639	277/459 (60%)
Shmt	NP_572278.1	SHMT	82..493	CDD:99733	262/412 (64%)
SHMT2	NP_005403.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..51		3/20 (15%)
SHMT2	NP_005403.2	PLN03226	45..502	CDD:215639	278/459 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	536	1.000	Domainoid score	I270
eggNOG	1	0.900	-	-		E1_COG0112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1055
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60631
OrthoDB	1	1.010	-	-		D234916at33208
OrthoFinder	1	1.000	-	-		FOG0000859
OrthoInspector	1	1.000	-	-		otm41798
orthoMCL	1	0.900	-	-		OOG6_100262
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2136
SonicParanoid	1	1.000	-	-		X557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.810