DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shmt and SHMT1

DIOPT Version :9

Sequence 1:	NP_572278.1	Gene:	Shmt / 31524	FlyBaseID:	FBgn0029823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_004160.3	Gene:	SHMT1 / 6470	HGNCID:	10850	Length:	483	Species:	Homo sapiens

Alignment Length:	462	Identity:	279/462 - (60%)
Similarity:	348/462 - (75%)	Gaps:	3/462 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KLLQTPLAQGDPELAELIKKEKERQREGLEMIASENFTSVAVLESLSSCLTNKYSEGYPGKRYYG 139
            |:|..||...|.|:..:||||..|||.|||:||||||.|.||||:|.|||.|||||||||:||||
Human    20 KMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYG 84

  Fly   140 GNEYIDRIELLAQQRGRELFNLDDEKWGVNVQPYSGSPANLAVYTGVCRPHDRIMGLDLPDGGHL 204
            |.|:||.:|.|.|:|..:.:.||.:.||||||||||||||.||||.:..||.|||||||||||||
Human    85 GTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHL 149

  Fly   205 THGFFTPTKKISATSIFFESMPYKVNPETGIIDYDKLAEAAKNFRPQIIIAGISCYSRLLDYARF 269
            ||||.|..|||||||||||||||||||:||.|:||:|.|.|:.|.|::||||.|||||.|:|||.
Human   150 THGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARL 214

  Fly   270 RQICDDVGAYLMADMAHVAGIVAAGLIPSPFEWADIVTTTTHKTLRGPRAGVIFFRKGVRST-KA 333
            |:|.|:.||||||||||::|:||||::|||||...:|||||||||||.|||:||:||||:|. ..
Human   215 RKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPK 279

  Fly   334 NGDKVLYDLEERINQAVFPSLQGGPHNNAVAGIATAFKQAKSPEFKAYQTQVLKNAKALCDGLIS 398
            .|.::||:||..||.||||.|||||||:|:||:|.|.|||.:.|||.||.||:.|.:||.:.|..
Human   280 TGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTE 344

  Fly   399 RGYQVATGGTDVHLVLVDVRKAGLTGAKAEYILEEVGIACNKNTVPGDKSAMNPSGIRLGTPALT 463
            .||::.|||:|.||:|||:|..|..|.:||.:||...|||||||.|||:||:.|||:||||||||
Human   345 LGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALT 409

  Fly   464 TRGLAEQDIEQVVAFIDAALKVGVQAAKLAG-SPKITDYHKTLAENVELKAQVDEIRKNVAQFSR 527
            :|||.|:|.::|..||...:::.:|.....| ...:.::.:.||.: :.:|.|..:|:.|..|:.
Human   410 SRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGD-KYQAAVQALREEVESFAS 473

  Fly   528 KFPLPGL 534
            .||||||
Human   474 LFPLPGL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shmt	NP_572278.1	PLN03226	79..536	CDD:215639	277/458 (60%)
Shmt	NP_572278.1	SHMT	82..493	CDD:99733	261/411 (64%)
SHMT1	NP_004160.3	PLN03226	24..480	CDD:215639	275/456 (60%)
SHMT1	NP_004160.3	SHMT	26..425	CDD:278870	259/398 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147673
Domainoid	1	1.000	536	1.000	Domainoid score	I270
eggNOG	1	0.900	-	-		E1_COG0112
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3074
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1055
Isobase	1	0.950	-	0	Normalized mean entropy	S295
OMA	1	1.010	-	-		QHG60631
OrthoDB	1	1.010	-	-		D234916at33208
OrthoFinder	1	1.000	-	-		FOG0000859
OrthoInspector	1	1.000	-	-		otm41798
orthoMCL	1	0.900	-	-		OOG6_100262
Panther	1	1.100	-	-	LDO	PTHR11680
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2136
SonicParanoid	1	1.000	-	-		X557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750