DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shmt and shmt1

DIOPT Version :9

Sequence 1:	NP_572278.1	Gene:	Shmt / 31524	FlyBaseID:	FBgn0029823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_957340.1	Gene:	shmt1 / 394021	ZFINID:	ZDB-GENE-040426-1558	Length:	481	Species:	Danio rerio

Alignment Length:	466	Identity:	290/466 - (62%)
Similarity:	361/466 - (77%)	Gaps:	4/466 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KLLQTPLAQGDPELAELIKKEKERQREGLEMIASENFTSVAVLESLSSCLTNKYSEGYPGKRYYG 139
            |::..||:..|||:.::|||||:||..|||:||||||||.||||:|.||:.|||||||||:||||
Zfish    17 KMMLEPLSTNDPEVFDIIKKEKKRQTYGLELIASENFTSRAVLEALGSCMNNKYSEGYPGQRYYG 81

  Fly   140 GNEYIDRIELLAQQRGRELFNLDDEKWGVNVQPYSGSPANLAVYTGVCRPHDRIMGLDLPDGGHL 204
            |.|::|.:|.|.|.|..:::.||.|||||||||||||.||.||||.:..||.|||||||||||||
Zfish    82 GTEHVDELERLCQDRALKVYGLDPEKWGVNVQPYSGSRANFAVYTAIVEPHGRIMGLDLPDGGHL 146

  Fly   205 THGFFTPTKKISATSIFFESMPYKVNPETGIIDYDKLAEAAKNFRPQIIIAGISCYSRLLDYARF 269
            ||||.|..||||||||||||||||||||||.|||::|.|.|:.|.|::||||.|||||.|||:|.
Zfish   147 THGFMTDKKKISATSIFFESMPYKVNPETGYIDYNRLEENARLFHPRLIIAGTSCYSRNLDYSRL 211

  Fly   270 RQICDDVGAYLMADMAHVAGIVAAGLIPSPFEWADIVTTTTHKTLRGPRAGVIFFRKGVRSTKA- 333
            |:|.|:.||||:|||||::|:||||::|||||:.|:|:|||||||||.|||||||||||||..|
Zfish   212 RKIADENGAYLLADMAHISGLVAAGVVPSPFEYCDVVSTTTHKTLRGCRAGVIFFRKGVRSVDAK 276

  Fly   334 NGDKVLYDLEERINQAVFPSLQGGPHNNAVAGIATAFKQAKSPEFKAYQTQVLKNAKALCDGLIS 398
            .|.:.:|:||..|||||||.|||||||:|:||:|.|.|||.:||||.||.|||.|.|||...|:.
Zfish   277 TGKETMYNLESLINQAVFPGLQGGPHNHAIAGVAVALKQALTPEFKTYQLQVLANCKALASALMD 341

  Fly   399 RGYQVATGGTDVHLVLVDVRKAGLTGAKAEYILEEVGIACNKNTVPGDKSAMNPSGIRLGTPALT 463
            :||:|.|||:|.||:|||:|..|..|.:||.:||...|||||||.||||||:.|||:|||:||||
Zfish   342 KGYKVVTGGSDNHLILVDLRSNGTDGGRAEKVLEACAIACNKNTCPGDKSALRPSGLRLGSPALT 406

  Fly   464 TRGLAEQDIEQVVAFIDAALKVGVQAAKLAGSPKIT--DYHKTLAENVELKAQVDEIRKNVAQFS 526
            :|||.|:...:|..||...:.:.::..|.. :||.|  ::.:.|::|.:.:.:..||||.|..|:
Zfish   407 SRGLLEEHFHKVAEFIHQGIVLTLEIQKNM-NPKATLKEFKEELSQNEKYQLKTKEIRKEVEDFA 470

  Fly   527 RKFPLPGLETL 537
            .|||:|||..|
Zfish   471 GKFPMPGLPEL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shmt	NP_572278.1	PLN03226	79..536	CDD:215639	288/459 (63%)
Shmt	NP_572278.1	SHMT	82..493	CDD:99733	269/411 (65%)
shmt1	NP_957340.1	PLN03226	22..478	CDD:215639	286/456 (63%)
shmt1	NP_957340.1	SHMT	23..422	CDD:278870	267/398 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581500
Domainoid	1	1.000	559	1.000	Domainoid score	I235
eggNOG	1	0.900	-	-		E1_COG0112
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3074
Inparanoid	1	1.050	597	1.000	Inparanoid score	I929
OMA	1	1.010	-	-		QHG60631
OrthoDB	1	1.010	-	-		D234916at33208
OrthoFinder	1	1.000	-	-		FOG0000859
OrthoInspector	1	1.000	-	-		otm25806
orthoMCL	1	0.900	-	-		OOG6_100262
Panther	1	1.100	-	-	LDO	PTHR11680
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2136
SonicParanoid	1	1.000	-	-		X557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800