Protein Alignment Shmt and Shmt2

DIOPT Version :10

• Sequence 1: NP_572278.1
• Gene: Shmt / 31524
• FlyBaseID: FBgn0029823
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001008323.1
• Gene: Shmt2 / 299857
• RGDID: 1308582
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 500
• Identity: 284/500 - (56%)
• Similarity: 368/500 - (73%)
• Gaps: 15/500 - (3%)

  Fly    37 GALTRIAAKKQPSPTPFLPAIRRYSDSKQSTLKNMADQKLLQTPLAQGDPELAELIKKEKERQRE 101
            |.|..:||:.|            :|:..|......|.....|..|:..|||:.||:::||:||..
  Rat    17 GQLVCMAARAQ------------HSEVAQKQAGEAAGGWTGQESLSDSDPEIWELLQREKDRQCR 69

  Fly   102 GLEMIASENFTSVAVLESLSSCLTNKYSEGYPGKRYYGGNEYIDRIELLAQQRGRELFNLDDEKW 166
            |||:||||||.|.|.||:|.|||.|||||||||||||||.|.:|.||||.|:|..|.|:||..:|
  Rat    70 GLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQW 134

  Fly   167 GVNVQPYSGSPANLAVYTGVCRPHDRIMGLDLPDGGHLTHGFFTPTKKISATSIFFESMPYKVNP 231
            |||||||||||||||.||.:.:|||||||||||||||||||:.:..|:||||||||||||||:||
  Rat   135 GVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNP 199

  Fly   232 ETGIIDYDKLAEAAKNFRPQIIIAGISCYSRLLDYARFRQICDDVGAYLMADMAHVAGIVAAGLI 296
            :||:||||:||..|:.|||::||||.|.|:||:||||.|::||:|.|:|:|||||::|:|||.:|
  Rat   200 QTGLIDYDQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVI 264

  Fly   297 PSPFEWADIVTTTTHKTLRGPRAGVIFFRKGVRST-KANGDKVLYDLEERINQAVFPSLQGGPHN 360
            ||||::||||||||||||||.|:|:||:|||||:. ...|.::.|..|:|||.||||||||||||
  Rat   265 PSPFKYADIVTTTTHKTLRGARSGLIFYRKGVRTVDPKTGQEIPYTFEDRINFAVFPSLQGGPHN 329

  Fly   361 NAVAGIATAFKQAKSPEFKAYQTQVLKNAKALCDGLISRGYQVATGGTDVHLVLVDVRKAGLTGA 425
            :|:|.:|.|.|||.:|.|:.|..|||:||:|:.|.|:.|||.:.:||||.||||||:|..||.||
  Rat   330 HAIAAVAVALKQACTPMFREYSLQVLRNAQAMADALLKRGYSLVSGGTDTHLVLVDLRPKGLDGA 394

  Fly   426 KAEYILEEVGIACNKNTVPGDKSAMNPSGIRLGTPALTTRGLAEQDIEQVVAFIDAALKVGVQAA 490
            :||.:||.|.|..||||.|||:||:.|.|:|||.||||:|...|.|..:||.|||..:.:|::..
  Rat   395 RAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVK 459

  Fly   491 KLAGSPKITDYHKTLAENVELKAQVDEIRKNVAQFSRKFPLPGLE 535
            :  .:.|:.|:...|.::.|...::..:|:.|.||:|.||:||.:
  Rat   460 R--KTAKLQDFKSFLLKDPETSQRLANLRQQVEQFARGFPMPGFD 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shmt	NP_572278.1	PLN03226	79..536	CDD:215639	275/457 (60%)
Shmt2	NP_001008323.1	PLN03226	45..502	CDD:215639	276/458 (60%)