DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shmt and shm2

DIOPT Version :9

Sequence 1:	NP_572278.1	Gene:	Shmt / 31524	FlyBaseID:	FBgn0029823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_593668.2	Gene:	shm2 / 2542242	PomBaseID:	SPAC18G6.04c	Length:	488	Species:	Schizosaccharomyces pombe

Alignment Length:	489	Identity:	265/489 - (54%)
Similarity:	352/489 - (71%)	Gaps:	12/489 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LPAIRRYSDSKQSTLKN-----MADQ-KLLQTPLAQGDPELAELIKKEKERQREGLEMIASENFT 112
            :..:|::..:..|::..     .|:| |||:.|||:.||.:.::::.||.||:|.:.:|||||||
pombe     1 MAVLRQFVKNSYSSIPKRFYALSANQKKLLKAPLAECDPTVYKILESEKSRQKESIALIASENFT 65

  Fly   113 SVAVLESLSSCLTNKYSEGYPGKRYYGGNEYIDRIELLAQQRGRELFNLDDEKWGVNVQPYSGSP 177
            |.||:::|.|.:.|||||||||.|||||||:||:.|.|.|.|..|.|:||.|||||||||:||||
pombe    66 SRAVMDALGSIMQNKYSEGYPGARYYGGNEFIDQAERLCQTRALEAFHLDGEKWGVNVQPHSGSP 130

  Fly   178 ANLAVYTGVCRPHDRIMGLDLPDGGHLTHGFFTPTKKISATSIFFESMPYKVNPETGIIDYDKLA 242
            |||..|..|.:||||:||||||.||||:|||.||.|.|||.|.:|.:|||.||.||||||||.|.
pombe   131 ANLQAYQAVMKPHDRLMGLDLPHGGHLSHGFSTPQKAISAVSTYFSTMPYNVNKETGIIDYDSLE 195

  Fly   243 EAAKNFRPQIIIAGISCYSRLLDYARFRQICDDVGAYLMADMAHVAGIVAAGLIPSPFEWADIVT 307
            :||..|||::|:||.|.|:||:||.|.|:|.:...|||:.||||::|:||||:||||||:|||||
pombe   196 KAAIQFRPKVIVAGASAYARLVDYKRMRKITEMCNAYLLCDMAHISGLVAAGVIPSPFEYADIVT 260

  Fly   308 TTTHKTLRGPRAGVIFFRKGVRSTKANGDKVLYDLEERINQAVFPSLQGGPHNNAVAGIATAFKQ 372
            |||||:|||||..:||:|||.||....|:.:||:||::||.:|||..||||||:.:..:|.|..|
pombe   261 TTTHKSLRGPRGAMIFYRKGTRSHDKRGNPILYELEDKINFSVFPGHQGGPHNHTITALAVALGQ 325

  Fly   373 AKSPEFKAYQTQVLKNAKALCDGLISRGYQVATGGTDVHLVLVDVRKAGLTGAKAEYILEEVGIA 437
            ||:|||..||..||.||||:.:..|:|||::.:||||.||||||:...|:.||:.|.|||.|.|:
pombe   326 AKTPEFYQYQKDVLSNAKAMANAFITRGYKLVSGGTDTHLVLVDLTDKGVDGARVERILELVNIS 390

  Fly   438 CNKNTVPGDKSAMNPSGIRLGTPALTTRGLAEQDIEQVVAFIDAAL----KVGVQAAKLAGSPKI 498
            .|||||||||||:.|.|:||||||.||||..|:|.|:||..||..:    |:. :||...|..|.
pombe   391 ANKNTVPGDKSALIPRGLRLGTPACTTRGFDEKDFERVVELIDEVVSLTKKIN-EAALKEGKSKF 454

  Fly   499 TDYHKTLAENVELKAQVDEIRKNVAQFSRKFPLP 532
            .|:...:.:..:. :::.:::|.|..::.||..|
pombe   455 RDFKAYVGDGSKF-SEIAKLKKEVITWAGKFDFP 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shmt	NP_572278.1	PLN03226	79..536	CDD:215639	258/458 (56%)
Shmt	NP_572278.1	SHMT	82..493	CDD:99733	248/414 (60%)
shm2	NP_593668.2	PLN03226	23..487	CDD:215639	262/465 (56%)
shm2	NP_593668.2	SHMT	34..432	CDD:278870	244/397 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	509	1.000	Domainoid score	I52
eggNOG	1	0.900	-	-		E1_COG0112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I212
OMA	1	1.010	-	-		QHG60631
OrthoFinder	1	1.000	-	-		FOG0000859
OrthoInspector	1	1.000	-	-		otm47344
orthoMCL	1	0.900	-	-		OOG6_100262
Panther	1	1.100	-	-	LDO	PTHR11680
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2136
SonicParanoid	1	1.000	-	-		X557
TreeFam	1	0.960	-	-
	13	12.860