DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shmt and Shmt1

DIOPT Version :9

Sequence 1:	NP_572278.1	Gene:	Shmt / 31524	FlyBaseID:	FBgn0029823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_033197.2	Gene:	Shmt1 / 20425	MGIID:	98299	Length:	478	Species:	Mus musculus

Alignment Length:	475	Identity:	284/475 - (59%)
Similarity:	352/475 - (74%)	Gaps:	11/475 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 MAD---------QKLLQTPLAQGDPELAELIKKEKERQREGLEMIASENFTSVAVLESLSSCLTN 126
            |||         :|:|..||...|.|:..:||||..|||.|||:||||||.|.||||:|.|||.|
Mouse     1 MADRDATLWASHEKMLSQPLKDSDAEVYSIIKKESNRQRVGLELIASENFASRAVLEALGSCLNN 65

  Fly   127 KYSEGYPGKRYYGGNEYIDRIELLAQQRGRELFNLDDEKWGVNVQPYSGSPANLAVYTGVCRPHD 191
            ||||||||:|||||.|:||.:|:|.|:|..:.::||.:.||||||||||||||.||||.:..||.
Mouse    66 KYSEGYPGQRYYGGTEFIDELEMLCQKRALQAYHLDPQCWGVNVQPYSGSPANFAVYTALVEPHG 130

  Fly   192 RIMGLDLPDGGHLTHGFFTPTKKISATSIFFESMPYKVNPETGIIDYDKLAEAAKNFRPQIIIAG 256
            |||||||||||||||||.|..|||||||||||||||||.||||.|:||:|.|.|..|.|::||||
Mouse   131 RIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVYPETGYINYDQLEENASLFHPKLIIAG 195

  Fly   257 ISCYSRLLDYARFRQICDDVGAYLMADMAHVAGIVAAGLIPSPFEWADIVTTTTHKTLRGPRAGV 321
            .|||||.|||||.|:|.||.||||||||||::|:||||::|||||...:|||||||||||.|||:
Mouse   196 TSCYSRNLDYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGM 260

  Fly   322 IFFRKGVRST-KANGDKVLYDLEERINQAVFPSLQGGPHNNAVAGIATAFKQAKSPEFKAYQTQV 385
            ||:||||||. ...|.:..|:||..||.||||.|||||||:|:||:|.|.|||.:.|||.||.||
Mouse   261 IFYRKGVRSVDPKTGKETYYELESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTTEFKIYQLQV 325

  Fly   386 LKNAKALCDGLISRGYQVATGGTDVHLVLVDVRKAGLTGAKAEYILEEVGIACNKNTVPGDKSAM 450
            |.|.:||.|.|...||::.|||:|.||:|:|:|..|..|.:||.:||...|||||||.||||||:
Mouse   326 LANCRALSDALTELGYKIVTGGSDNHLILMDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSAL 390

  Fly   451 NPSGIRLGTPALTTRGLAEQDIEQVVAFIDAALKVGVQ-AAKLAGSPKITDYHKTLAENVELKAQ 514
            .|||:||||||||:|||.|:|.::|..||...:::.:| .:.:|....:.::.:.||.:.::::.
Mouse   391 RPSGLRLGTPALTSRGLLEEDFQKVAHFIHRGIELTLQIQSHMATKATLKEFKEKLAGDEKIQSA 455

  Fly   515 VDEIRKNVAQFSRKFPLPGL 534
            |..:|:.|..|:..|.||||
Mouse   456 VATLREEVENFASNFSLPGL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shmt	NP_572278.1	PLN03226	79..536	CDD:215639	279/458 (61%)
Shmt	NP_572278.1	SHMT	82..493	CDD:99733	265/412 (64%)
Shmt1	NP_033197.2	PLN03226	13..475	CDD:215639	279/461 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837756
Domainoid	1	1.000	543	1.000	Domainoid score	I263
eggNOG	1	0.900	-	-		E1_COG0112
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3074
Inparanoid	1	1.050	574	1.000	Inparanoid score	I1045
Isobase	1	0.950	-	0	Normalized mean entropy	S295
OMA	1	1.010	-	-		QHG60631
OrthoDB	1	1.010	-	-		D234916at33208
OrthoFinder	1	1.000	-	-		FOG0000859
OrthoInspector	1	1.000	-	-		otm43850
orthoMCL	1	0.900	-	-		OOG6_100262
Panther	1	1.100	-	-	LDO	PTHR11680
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2136
SonicParanoid	1	1.000	-	-		X557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750