DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shmt and mel-32

DIOPT Version :9

Sequence 1:	NP_572278.1	Gene:	Shmt / 31524	FlyBaseID:	FBgn0029823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_741197.1	Gene:	mel-32 / 175915	WormBaseID:	WBGene00003214	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	509	Identity:	293/509 - (57%)
Similarity:	367/509 - (72%)	Gaps:	18/509 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TGKLSGALTRIAAKKQPSPTPFLPAIRRYSDSKQSTLKNMADQKLLQTPLAQGDPELAELIKKEK 96
            ||..:||.::.....:...|| |..::|:        |...::.:|...:.:.|||:.:::|.||
Worm    12 TGLFAGASSQCKMADRQVHTP-LAKVQRH--------KYTNNENILVDHVEKVDPEVFDIMKNEK 67

  Fly    97 ERQREGLEMIASENFTSVAVLESLSSCLTNKYSEGYPGKRYYGGNEYIDRIELLAQQRGRELFNL 161
            :|||.|||:||||||||.||:::|.|.:.|||||||||.|||||||:||::|||.|:|..|:|.|
Worm    68 KRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYGGNEFIDQMELLCQKRALEVFGL 132

  Fly   162 DDEKWGVNVQPYSGSPANLAVYTGVCRPHDRIMGLDLPDGGHLTHGFFTPTKKISATSIFFESMP 226
            |..||||||||.||||||.||||.:...:.||||||||||||||||||||.:|:||||.||:|:|
Worm   133 DPAKWGVNVQPLSGSPANFAVYTAIVGSNGRIMGLDLPDGGHLTHGFFTPARKVSATSEFFQSLP 197

  Fly   227 YKVNPETGIIDYDKLAEAAKNFRPQIIIAGISCYSRLLDYARFRQICDDVGAYLMADMAHVAGIV 291
            |||:|.||:||||||.:.|..|||:.||||:|||:|.|||.|||:|....|||||:||||::|:|
Worm   198 YKVDPTTGLIDYDKLEQNAMLFRPKAIIAGVSCYARHLDYERFRKIATKAGAYLMSDMAHISGLV 262

  Fly   292 AAGLIPSPFEWADIVTTTTHKTLRGPRAGVIFFRKGVRSTKANGDKVLYDLEERINQAVFPSLQG 356
            ||||||||||::|:|||||||:|||||..:||:|||||||.|.|...||||||:||.||||.|||
Worm   263 AAGLIPSPFEYSDVVTTTTHKSLRGPRGALIFYRKGVRSTNAKGVDTLYDLEEKINSAVFPGLQG 327

  Fly   357 GPHNNAVAGIATAFKQAKSPEFKAYQTQVLKNAKALCDGLISRGYQVATGGTDVHLVLVDVRKAG 421
            ||||:.:||||.|.:|..|.:|..|..|||||||.|.:.:...||.:||||||.||:|||:|..|
Worm   328 GPHNHTIAGIAVALRQCLSEDFVQYGEQVLKNAKTLAERMKKHGYALATGGTDNHLLLVDLRPIG 392

  Fly   422 LTGAKAEYILEEVGIACNKNTVPGDKSAMNPSGIRLGTPALTTRGLAEQDIEQVVAFIDAALKVG 486
            :.||:||::|:...|||||||.|||.||:.|.||||||||||:||..|||.|:|..||..    |
Worm   393 VEGARAEHVLDLAHIACNKNTCPGDVSALRPGGIRLGTPALTSRGFQEQDFEKVGDFIHE----G 453

  Fly   487 VQAAKL----AGSPKITDYHKTLAENVELKAQVDEIRKNVAQFSRKFPLPGLET 536
            ||.||.    ||. .:.|:......|...|..|.::.|.|.:||.||.:||.||
Worm   454 VQIAKKYNAEAGK-TLKDFKSFTETNEPFKKDVADLAKRVEEFSTKFEIPGNET 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shmt	NP_572278.1	PLN03226	79..536	CDD:215639	281/460 (61%)
Shmt	NP_572278.1	SHMT	82..493	CDD:99733	267/414 (64%)
mel-32	NP_741197.1	PLN03226	51..503	CDD:215639	279/456 (61%)
mel-32	NP_741197.1	AAT_I	52..450	CDD:302748	260/397 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159669
Domainoid	1	1.000	544	1.000	Domainoid score	I126
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3074
Inparanoid	1	1.050	571	1.000	Inparanoid score	I573
Isobase	1	0.950	-	0	Normalized mean entropy	S295
OMA	1	1.010	-	-		QHG60631
OrthoDB	1	1.010	-	-		D234916at33208
OrthoFinder	1	1.000	-	-		FOG0000859
OrthoInspector	1	1.000	-	-		oto17934
orthoMCL	1	0.900	-	-		OOG6_100262
Panther	1	1.100	-	-	LDO	PTHR11680
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2136
SonicParanoid	1	1.000	-	-		X557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890