DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shmt and Shmt2

DIOPT Version :9

Sequence 1:	NP_572278.1	Gene:	Shmt / 31524	FlyBaseID:	FBgn0029823	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_082506.1	Gene:	Shmt2 / 108037	MGIID:	1277989	Length:	504	Species:	Mus musculus

Alignment Length:	500	Identity:	283/500 - (56%)
Similarity:	368/500 - (73%)	Gaps:	15/500 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GALTRIAAKKQPSPTPFLPAIRRYSDSKQSTLKNMADQKLLQTPLAQGDPELAELIKKEKERQRE 101
            |.|..:||:.|            :|...|:.....|.....|..|:..|||:.||:::||:||..
Mouse    17 GQLVCMAARAQ------------HSKVAQTQAGEAAGGWTGQESLSDSDPEMWELLQREKDRQCR 69

  Fly   102 GLEMIASENFTSVAVLESLSSCLTNKYSEGYPGKRYYGGNEYIDRIELLAQQRGRELFNLDDEKW 166
            |||:||||||.|.|.||:|.|||.|||||||||||||||.|.:|.||||.|:|..|.|:||..:|
Mouse    70 GLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQW 134

  Fly   167 GVNVQPYSGSPANLAVYTGVCRPHDRIMGLDLPDGGHLTHGFFTPTKKISATSIFFESMPYKVNP 231
            |||||||||||||||.||.:.:|||||||||||||||||||:.:..|:||||||||||||||:||
Mouse   135 GVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNP 199

  Fly   232 ETGIIDYDKLAEAAKNFRPQIIIAGISCYSRLLDYARFRQICDDVGAYLMADMAHVAGIVAAGLI 296
            :||:||||:||..|:.|||::||||.|.|:||:||||.|::||:|.|:|:|||||::|:|||.:|
Mouse   200 QTGLIDYDQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVRAHLLADMAHISGLVAAKVI 264

  Fly   297 PSPFEWADIVTTTTHKTLRGPRAGVIFFRKGVRST-KANGDKVLYDLEERINQAVFPSLQGGPHN 360
            ||||::||:|||||||||||.|:|:||:|||||:. ...|.::.|..|:|||.||||||||||||
Mouse   265 PSPFKYADVVTTTTHKTLRGARSGLIFYRKGVRTVDPKTGKEIPYTFEDRINFAVFPSLQGGPHN 329

  Fly   361 NAVAGIATAFKQAKSPEFKAYQTQVLKNAKALCDGLISRGYQVATGGTDVHLVLVDVRKAGLTGA 425
            :|:|.:|.|.|||.:|.|:.|..|||:||:|:.|.|:.|||.:.:||||.||||||:|..||.||
Mouse   330 HAIAAVAVALKQACTPMFREYSLQVLRNAQAMADALLKRGYSLVSGGTDTHLVLVDLRPKGLDGA 394

  Fly   426 KAEYILEEVGIACNKNTVPGDKSAMNPSGIRLGTPALTTRGLAEQDIEQVVAFIDAALKVGVQAA 490
            :||.:||.|.|..||||.|||:||:.|.|:|||.||||:|...|.|..:||.|||..:.:|::..
Mouse   395 RAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVK 459

  Fly   491 KLAGSPKITDYHKTLAENVELKAQVDEIRKNVAQFSRKFPLPGLE 535
            :  .:.|:.|:...|.::.|...::..:|:.|.||:|.||:||.:
Mouse   460 R--KTAKLQDFKSFLLKDPETSQRLANLRQQVEQFARGFPMPGFD 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shmt	NP_572278.1	PLN03226	79..536	CDD:215639	274/457 (60%)
Shmt	NP_572278.1	SHMT	82..493	CDD:99733	260/411 (63%)
Shmt2	NP_082506.1	PLN03226	45..502	CDD:215639	275/458 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	543	1.000	Domainoid score	I263
eggNOG	1	0.900	-	-		E1_COG0112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	574	1.000	Inparanoid score	I1045
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60631
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000859
OrthoInspector	1	1.000	-	-		otm43850
orthoMCL	1	0.900	-	-		OOG6_100262
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2136
SonicParanoid	1	1.000	-	-		X557
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.800