DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12236 and ttk

DIOPT Version :9

Sequence 1:	NP_727050.1	Gene:	CG12236 / 31523	FlyBaseID:	FBgn0029822	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	118/489 - (24%)
Similarity:	201/489 - (41%)	Gaps:	129/489 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TQQYSLRWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHPH 68
            :|::.|||||:..:|....|.....:.|.||:|.|:|:.:||||:|||:||.||..:|..:|..|
  Fly     5 SQRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKH 69

  Fly    69 PVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELLAVQGLTAEEKEKPQIPVAPLISE 133
            |::|.|.:.:.|:.|:::|||:|||:|.||.|.:||:.||.|.::|||....:||.
  Fly    70 PIVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPS--------- 125

  Fly   134 HKLIKTIPSTIRAVNEQQQQVSNVAQAQTATQTIEIPAATLLQATNASQVPSQVVAAAAAAAAAQ 198
                                                |||                |||.|.|...
  Fly   126 ------------------------------------PAA----------------AAAGAGATGS 138

  Fly   199 QLQVQHQQQQHHHVQTTQIQHIQVQSAPPPQQQQQQQQQQQQQQQQQQQQQQQQSQQQQTTPVQT 263
            :          ....|.|:|.||....|          |:.:.|..........:....|.|||.
  Fly   139 E----------STATTPQLQRIQPYLVP----------QRNRSQAGGLLASAANAGNTPTLPVQP 183

  Fly   264 QHLTITNAVALPAASSVKKRKITFSDDDDNMYTTETVDYAVKDEQTIVKTAEMTFLRGAVKMDIP 328
               ::.::..:|.....:.||::.|.:....      ||...|.:.::..:...   |..||...
  Fly   184 ---SLLSSALMPKRKRGRPRKLSGSSNGTGN------DYDDFDRENMMNDSSDL---GNGKMCNE 236

  Fly   329 DYI---VGEVDDRLSDGATPQTSQDATTAAAQNVAQYSSEYEILTESEMEEKYQADADNA----- 385
            .|.   .|..|::.:.|.|...::...:..::. ::.|.::.:::..|         ||:
  Fly   237 SYSGNDDGSDDNQPNAGHTDDLNESRDSLPSKR-SKNSKDHRVVSHHE---------DNSTSVTP 291

  Fly   386 -EIAIEMT-RLLGTASGTPGAGSGQVMEDSGGGSATTGPSTTVSVTQVKSDSKASG-----TNAA 443
             :...|:: ||.|::|.|..|        :..|.::||||.|:|:.:: ||.:.|.     |...
  Fly   292 TKATPELSQRLFGSSSTTISA--------TAPGGSSTGPSETISLLEI-SDERESAPVHLPTILG 347

  Fly   444 LKPGSVTVARSSKSGATASAPPAGSDEESVQYTG 477
            ||..::.....::.|:..:  |..|..:..|.||
  Fly   348 LKIRAINTTTPAQQGSPQT--PTKSKPKIRQATG 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12236	NP_727050.1	BTB	22..116	CDD:279045	42/93 (45%)
		BTB	33..116	CDD:197585	40/82 (49%)
		Herpes_capsid	<376..467	CDD:283714	24/102 (24%)
		C2H2 Zn finger	483..512	CDD:275371
		C2H2 Zn finger	514..535	CDD:275371
ttk	NP_001189329.1	BTB	23..119	CDD:279045	44/95 (46%)
		BTB	34..119	CDD:197585	42/84 (50%)
		C2H2 Zn finger	612..638	CDD:275370
		zf-C2H2_4	646..669	CDD:290605
		C2H2 Zn finger	648..669	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020