DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12236 and lola

DIOPT Version :9

Sequence 1:	NP_727050.1	Gene:	CG12236 / 31523	FlyBaseID:	FBgn0029822	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster

Alignment Length:	642	Identity:	147/642 - (22%)
Similarity:	241/642 - (37%)	Gaps:	166/642 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATTQQYSLRWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENP 65
            |...||:.|||||:...|....|....|:..||.:|..:|:.:||||||||:||.||..:.:|..
  Fly     1 MDDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQY 65

  Fly    66 HPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELLAVQGLTAEEKEKPQIPVAPL 130
            ..||:.|.|.:|:::|.:::::||:||||:.|:.|.:.|:.||.|.::|| ::.:....:...|.
  Fly    66 DKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGL-SDNRTGGGVAPKPE 129

  Fly   131 ISEH----KL--IKTIPSTIRA-----------------------VNEQQQQV------------ 154
            .|.|    ||  ..|:..|.||                       .:.::::|
  Fly   130 SSGHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMENDAHDN 194

  Fly   155 --SNVAQAQTATQTIEIPAATLLQATNA-----SQVPSQVVAAAAAAAAAQQLQVQHQQQQHHHV 212
              |:|.||..:.|:|       ||.|.|     :.|.:|:.:..||..::|....|.||......
  Fly   195 SNSSVLQAAASNQSI-------LQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTN 252

  Fly   213 QTTQIQHIQVQSAPPPQQQQQQQQQQQQQQQQQQQQQQQQSQQQQTTPVQTQHLTITNAVALPAA 277
            .|.:.:..::.|:..............||....|||.|..|....|..||.|        :...|
  Fly   253 VTKKTESAKLTSSTAAPASGASASAAVQQAHLHQQQAQTTSDAINTENVQAQ--------SQGGA 309

  Fly   278 SSVKKRKITFSDDDDNMYTTETVDYAVKDEQTIV-----------KTAEMTFLRGAVKMDIPDYI 331
            ..|:      .||:|            .||.:.|           .:|..:.:...|   :...:
  Fly   310 QGVQ------GDDED------------IDEGSAVGGPNSATGPNPASASASAVHAGV---VVKQL 353

  Fly   332 VGEVDDRLSDGATPQTSQDATTAAAQNVAQYSSEYEILTESEMEEKYQADADNAEIAIEMTRLLG 396
            ...||...|:..........::..::.|.:..:||:.....|..|....|.::..:. |:.:..|
  Fly   354 ASVVDKSSSNHKHKIKDNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTME-ELDQTAG 417

  Fly   397 TASGTPGAGSGQV--------MEDSGG------------------GSATTG------------PS 423
            |:.|  |.||.|.        .:|..|                  |..|.|            .|
  Fly   418 TSQG--GEGSSQTYATWQHDRSQDELGLMAQDAQQRDPQASKQDKGEQTEGAQDEFELDDCLLES 480

  Fly   424 TTVSVTQVKSDSKASGTNAALKPGSVTVARSSKSGATASAPPAGSDEESVQYTGLAPLNCSFCGR 488
            ..:.:||    :|........|.|::|.|:..::.|.|..    ..:.:|..||.|       |:
  Fly   481 NDIVITQ----NKDGFVLHVKKLGNITAAKLEENQAVAQQ----QGQAAVTVTGPA-------GQ 530

  Fly   489 PLKSVNALRRHIASRHSE--------------IQGKEHECFICMKSFKTKWSLSTHN 531
            |..::..|....|:.|||              :...|.|.....|......:::||:
  Fly   531 PTPTITELLNAAAASHSEPKPTLTTLTSTPIKLPSSECELINIKKIIPATTTIATHH 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12236	NP_727050.1	BTB	22..116	CDD:279045	38/93 (41%)
		BTB	33..116	CDD:197585	35/82 (43%)
		Herpes_capsid	<376..467	CDD:283714	25/128 (20%)
		C2H2 Zn finger	483..512	CDD:275371	7/42 (17%)
		C2H2 Zn finger	514..535	CDD:275371	3/18 (17%)
lola	NP_788308.3	BTB	22..117	CDD:279045	39/95 (41%)
		BTB	33..117	CDD:197585	36/84 (43%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010