DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12236 and bab2

DIOPT Version :9

Sequence 1:	NP_727050.1	Gene:	CG12236 / 31523	FlyBaseID:	FBgn0029822	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	122/513 - (23%)
Similarity:	198/513 - (38%)	Gaps:	138/513 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QQYSLRWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHPHP 69
            ||:.||||||..:||...|....::.||||:|..:|..|||||:|||:||.||:.:|.:||..||
  Fly   196 QQFCLRWNNYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHP 260

  Fly    70 VIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELLAVQGLTAE------EKEKPQIPVA 128
            :||.:.:.:.||.:::||||:||:||.|:.:...|:.||.|.::|| ||      |.....:|::
  Fly   261 IIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGL-AEVSAGRGEGGASALPMS 324

  Fly   129 PLISEHKLIKTIPSTIRAVNEQQQQVSNVAQAQTATQTIEIPAATLLQATNASQVPSQVVAAAAA 193
            ....|              :|::                |:.:||.:...:....|.:.:.|...
  Fly   325 AFDDE--------------DEEE----------------ELASATAILQQDGDADPDEEMKAKRP 359

  Fly   194 AAAAQQLQVQHQQQQHHHVQTTQIQHIQVQSAPPPQQQQQQQQQQQQQQQQQQQQQQQQSQQQQT 258
            ....:.:...:|:|:......:       .:.|.|..|..:.:..::.......|.|.|.....|
  Fly   360 RLLPEGVLDLNQRQRKRSRDGS-------YATPSPSLQGGESEISERGSSGTPGQSQSQPLAMTT 417

  Fly   259 TPVQTQHLTITNAVALPAASSVKKRKITFSDDDDNMYTTETVDYAVKDEQTIVKTAEMTFLRG-- 321
            :.:      :.|..|.|...:::.|....:              ||.:::............|
  Fly   418 STI------VRNPFASPNPQTLEGRNSAMN--------------AVANQRKSPAPTATGHSNGNS 462

  Fly   322 -----------AVKMDIPDYIVGEVDDRLSDGATPQTSQDATTAAAQNVAQYSSEYEILTESEME 375
                       ||:..:|.::...|        .|..|     |...:..|.::::::.....|.
  Fly   463 GAAMHSPPGGVAVQSALPPHMAAIV--------PPPPS-----AMHHHAQQLAAQHQLAHSHAMA 514

  Fly   376 EKYQADADNAEIAIEMTRLLGTASGTPGAGSGQVMEDSGGGSATTGPSTTVSVTQVKSDSKASGT 440
            ....|.|..|           .|:|..|||||    ...|.||.|| .|.|:         .||.
  Fly   515 SALAAAAAGA-----------GAAGAGGAGSG----SGSGASAPTG-GTGVA---------GSGA 554

  Fly   441 NAA---------LKPGSVTVARSSK-------------SGATASAPPAGS-DEESVQY 475
            .||         :||....:.|..:             .||.|:|..|.| ..:|.||
  Fly   555 GAAVGSHHDDMEIKPEIAEMIREEERAKMIESGGHGGWMGAAAAATGAASVAADSYQY 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12236	NP_727050.1	BTB	22..116	CDD:279045	42/93 (45%)
		BTB	33..116	CDD:197585	39/82 (48%)
		Herpes_capsid	<376..467	CDD:283714	28/112 (25%)
		C2H2 Zn finger	483..512	CDD:275371
		C2H2 Zn finger	514..535	CDD:275371
bab2	NP_523879.2	BTB	213..309	CDD:279045	44/96 (46%)
		BTB	224..309	CDD:197585	41/85 (48%)
		HTH_psq	645..690	CDD:283007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9606
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.010