DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12236 and CG6118

DIOPT Version :9

Sequence 1:	NP_727050.1	Gene:	CG12236 / 31523	FlyBaseID:	FBgn0029822	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001097806.1	Gene:	CG6118 / 41884	FlyBaseID:	FBgn0038339	Length:	967	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	96/532 - (18%)
Similarity:	166/532 - (31%)	Gaps:	175/532 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TTQQYSLRWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHP 67
            |..||.|.|||:..::.....:.:.::..|||::...|:..||||:|||.||.||::||.|||..
  Fly   389 TIDQYLLSWNNFHGNMCRGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSS 453

  Fly    68 HPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELLAVQGLTAEEK------------ 120
            ||:::...::...:..:::|||.|:|||:.|.|..||:.||.:.::||..|:.
  Fly   454 HPILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAEAMKIKGLHTEKNLDSDASDISSPH 518

  Fly   121 -----------------------------------------EKPQIPVAPLIS------------ 132
                                                     ..|.....||.|
  Fly   519 ESDGTECRYERGTHSVNITSGHAAGYGGAPSSQQSSPSPSLNGPNRCPTPLSSGGSGNPNYAGFR 583

  Fly   133 EH-----KLIKTIPSTIRAVNEQQQQVSNVAQAQTATQTIEIPAA-----TLLQATNASQVPSQV 187
            ||     .|.:|....:...|......:|......:..::.:..|     .:|||.:...:.|
  Fly   584 EHIKSKATLAETFMKNLNRNNNNNNSSNNYNHLGGSNGSLNLTEADSNSFAILQANSKKMLDS-- 646

  Fly   188 VAAAAAAAAAQQLQVQH--------------------QQQQHHHVQTTQIQHIQ----------- 221
             |.......|::..:.|                    ..:||.........|.|
  Fly   647 -ARKQHKYLAKRKILMHYNTELGGEKRLKEMERDRYPSAEQHDDALNNNHSHAQDNIMEPIITTI 710

  Fly   222 VQSAPPPQQ----------QQQQQQQQQQQQQQQQQQQQQQSQQQQTTPVQTQHLTITNAVALPA 276
            |...|||..          :...........|.|.......|...|:.........: |.|.:|.
  Fly   711 VPQTPPPSTHNNNFKIRLVESHHLTNNSNNNQNQSSNNNNSSSSPQSNDCNNDEEAL-NLVQIPN 774

  Fly   277 ASSVKKRKITFSDDDDNMYTTETVDYAVKDEQTIVKTAEMTFLRGAVKMDIPDYIVGEVDDRLSD 341
            |:..:.|:.|                    ......|.::..::..||.::
  Fly   775 ANGSRNREAT--------------------PTCATPTPDIQLIKREVKTEL-------------- 805

  Fly   342 GATPQTSQDATTAAAQNVAQYSSEYEILTESEMEEKYQADADNAEIAIEMTRLLGTASGTPGAGS 406
                        :.|:|::..:...:.:..:..:.||  |.:|....::|.......:..||.
  Fly   806 ------------SPAENLSNNNGHDDEMAGAGFDRKY--DDNNNNSGLDMETDSNNNNSKPGG-- 854

  Fly   407 GQVMEDSGGGSA 418
                 |:..|.|
  Fly   855 -----DNNNGLA 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12236	NP_727050.1	BTB	22..116	CDD:279045	36/93 (39%)
		BTB	33..116	CDD:197585	35/82 (43%)
		Herpes_capsid	<376..467	CDD:283714	10/43 (23%)
		C2H2 Zn finger	483..512	CDD:275371
		C2H2 Zn finger	514..535	CDD:275371
CG6118	NP_001097806.1	Myb_DNA-bind_4	20..97	CDD:290549
		BTB	408..508	CDD:279045	38/99 (38%)
		BTB	419..510	CDD:197585	37/90 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020