DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12236 and mamo

DIOPT Version :9

Sequence 1:	NP_727050.1	Gene:	CG12236 / 31523	FlyBaseID:	FBgn0029822	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster

Alignment Length:	705	Identity:	163/705 - (23%)
Similarity:	253/705 - (35%)	Gaps:	237/705 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TQQYSLRWNNYLRHLTYSLDNHRLNDDFVDVSL-CVDGRRIKAHKVVLSSCSSYFKEIFKENPHP 67
            ::.|.||||||..:|.........:...|||:| |.:|..|:|||||||:|||||:.:|.|:|..
  Fly     3 SEHYCLRWNNYQSNLLGVFSQLLQDGSLVDVTLVCSEGTSIRAHKVVLSACSSYFQSLFLEHPEG 67

  Fly    68 HPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELLAVQGL--------TAEEKE--- 121
            |.::|.|.::|.:|.:::||||:||||||...|.:.|:|||.|.|:||        |..|.|
  Fly    68 HLIVILKDVRFAELQTLVEFMYKGEVNVQYCQLSALLKTAESLKVKGLAEMTNQNTTLREPEREP 132

  Fly   122 ---KPQIPVAPLISEHKLIKTIPSTIRAVNEQQQQVSN---VAQAQTATQTIEIPAATLLQATNA 180
               :||.......|.||...:..:.:.|....|...:.   .|.|.|:|.|....||....||.|
  Fly   133 DRLRPQGGGGSGGSAHKAADSPAAALDATAATQAATATATATAAAATSTSTSATSAAATAAATAA 197

  Fly   181 --------------------------------------SQVPSQVVAAAAAAAAAQQLQVQHQQQ 207
                                                  |...|...|||||||||....|.|.::
  Fly   198 TSASTTATAAAGSSNTTTTTAATTTATCATAATSTAATSSSSSVTSAAAAAAAAASASGVAHSEE 262

  Fly   208 QHHHVQTT--QIQHIQVQSAPPPQQQQQ-----------QQQQQQQQQQQQ-------------- 245
            ......:|  |.:....:|:|.|.::..           :.::|:|.|..:
  Fly   263 ATSSSSSTGGQKREASDRSSPTPAKRSSRMHPADKVDVAEDREQEQNQADELLSEELLGRNLKDE 327

  Fly   246 ------------------QQQQQQQSQQQQTTPV-----QTQHLTITNAVALPAASSVKKRKITF 287
                              :.:......:::.||:     |..::...:|.|..||.......::.
  Fly   328 EDDDVDELDENEETKLRGRDEDDDDEDEEEDTPMPLDLYQRPNVEPKSAAAATAAQQGGSNSLSG 392

  Fly   288 S--------------DDDDNMYTTETVDYAVKDEQTIVKTAEMTFLRG-------AVKMDIPDYI 331
            |              ::::|..::...:......:|...:...|...|       ||..|..|..
  Fly   393 SSNACHTNSSSNSNNNNNNNNNSSSNNNNNTSSGKTSASSNGGTASSGGTADSVVAVDDDDDDDD 457

  Fly   332 VGE------VDDRLSDGATPQTSQD------ATTAAAQNVAQ----------------------- 361
            .|.      :||||......:...|      ..||.|:.:||
  Fly   458 GGHHHQRQVMDDRLEQDVDEEDLDDDVVVVGPATAMARGIAQRLAHQNLQRLHHTHHHAQHQHSQ 522

  Fly   362 ----YSSEY------------------------EIL-----TESEMEEKYQADADNAEIAIEMTR 393
                :|..:                        |||     .|.::|:..:||..:.::.:.|
  Fly   523 HHHPHSQHHHTPHHQQHHTHSDDEDAMPVIAKSEILDDDYDDEMDLEDDDEADNSSNDLGLNM-- 585

  Fly   394 LLGTASGTPGAGSGQVMEDSGGGSATTG----PSTTVSVTQVKSDSKASGTNAALKPGSVTVARS 454
                ..|:.|||.|      ||...:||    ||..::   :.|.|.|:...||   .::...||
  Fly   586 ----KMGSGGAGGG------GGVDLSTGSTLIPSPLIT---LPSSSAAAAAAAA---AAMESQRS 634

  Fly   455 SKSGATASAPPAGSDEESVQYTGLAPLNCSFCGRPLKSVNALRRHIASRHSEIQG 509
            :.:.:.|.|..||:.:.|:...|         |||           |||.|...|
  Fly   635 TPAMSAAQAAGAGASDLSIGGCG---------GRP-----------ASRSSRDGG 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12236	NP_727050.1	BTB	22..116	CDD:279045	46/102 (45%)
		BTB	33..116	CDD:197585	45/91 (49%)
		Herpes_capsid	<376..467	CDD:283714	23/94 (24%)
		C2H2 Zn finger	483..512	CDD:275371	8/27 (30%)
		C2H2 Zn finger	514..535	CDD:275371
mamo	NP_572932.2	BTB	21..118	CDD:279045	46/96 (48%)
		BTB	32..118	CDD:197585	45/85 (53%)
		C2H2 Zn finger	1082..1105	CDD:275368
		C2H2 Zn finger	1116..1137	CDD:275368
		C2H2 Zn finger	1149..1169	CDD:275368
		zf-C2H2	1469..1491	CDD:278523
		C2H2 Zn finger	1471..1491	CDD:275368
		zf-H2C2_2	1483..1506	CDD:290200
		C2H2 Zn finger	1499..1519	CDD:275368
		zf-H2C2_2	1511..1536	CDD:290200
		C2H2 Zn finger	1527..1547	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9606
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010