DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12236 and ZBTB43

DIOPT Version :9

Sequence 1:	NP_727050.1	Gene:	CG12236 / 31523	FlyBaseID:	FBgn0029822	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001129248.1	Gene:	ZBTB43 / 23099	HGNCID:	17908	Length:	467	Species:	Homo sapiens

Alignment Length:	583	Identity:	107/583 - (18%)
Similarity:	189/583 - (32%)	Gaps:	174/583 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TQQYSLRWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYF-KEIFKENPHP 67
            |..:.:.:.::...:...|:..|......|||:.|.|...:|||.||::.|.|| .::..:|  .
Human     5 TNSFRVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKN--S 67

  Fly    68 HPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELLAVQGLTAEEKEKPQIPVAPLIS 132
            ..:::...:......:|:...|.|.:.:....:.|:|..|..|
Human    68 RRIVLPDVMNPRVFENILLSSYTGRLVMPAPEIVSYLTAASFL---------------------- 110

  Fly   133 EHKLIKTIPSTIRAVNEQQQQVSNVAQAQTATQTIEIPAATLLQATNAS---QVPSQVVAAAAAA 194
                                |:.:|  ....|:.:|.....|.|..|..   |.||        :
Human   111 --------------------QMWHV--VDKCTEVLEGNPTVLCQKLNHGSDHQSPS--------S 145

  Fly   195 AAAQQLQVQHQQQQHHHVQTTQIQHIQVQSAPPPQQQQQQQQQQQQQQQQQQQQQQQQSQQQQTT 259
            ::...|....:.....|...             |:.|:.:..:.:::..:.:...|
Human   146 SSYNGLVESFELGSGGHTDF-------------PKAQELRDGENEEESTKDELSSQ--------- 188

  Fly   260 PVQTQHLTITNAVALPAASSVKKRKITFSDDDDNMYTTETVDYAVKD-EQTIVKTAEMTFLRGAV 323
                    :|....||:.||.:..::             :.:.|.:| |:....:||..:.|
Human   189 --------LTEHEYLPSNSSTEHDRL-------------STEMASQDGEEGASDSAEFHYTR--- 229

  Fly   324 KMDIPDYIVGEV----------DDRLSDG-------AT---PQTSQDATTAAAQNVAQYSSEYEI 368
                |.|....:          .:||...       ||   .|.::...|...::..|.|...|.
Human   230 ----PMYSKPSIMAHKRWIHVKPERLEQACEGMDVHATYDEHQVTESINTVQTEHTVQPSGVEED 290

  Fly   369 L------TESEMEEKYQADADNAEIAIE-----MTRLLGTASGTPGAGSGQVMEDSGGGSATTGP 422
            .      .|:|.:|  |||..|.:..::     |....|..|      .|.::......:...|.
Human   291 FHIGEKKVEAEFDE--QADESNYDEQVDFYGSSMEEFSGERS------DGNLIGHRQEAALAAGY 347

  Fly   423 STTVS-VTQVKSDSKASGTNAA--LKPGSVTVARSSKSGATASAPPAGSDEESVQYTGLAPLNCS 484
            |..:. ||.:|.::...|.:|.  |.|.....:.:.||         ..|.....:.||.|..|.
Human   348 SENIEMVTGIKEEASHLGFSATDKLYPCQCGKSFTHKS---------QRDRHMSMHLGLRPYGCG 403

  Fly   485 FCGRPLKSVNALRRHIASRHSEIQG--KEHECFICMKSFKTKWSLSTHNSRFHREMGCSTKGF 545
            .||:..|    ::.|:.. |.:|..  |.:||.||.|.|  .|     ...|||.:...||.:
Human   404 VCGKKFK----MKHHLVG-HMKIHTGIKPYECNICAKRF--MW-----RDSFHRHVTSCTKSY 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12236	NP_727050.1	BTB	22..116	CDD:279045	23/94 (24%)
		BTB	33..116	CDD:197585	21/83 (25%)
		Herpes_capsid	<376..467	CDD:283714	20/98 (20%)
		C2H2 Zn finger	483..512	CDD:275371	8/30 (27%)
		C2H2 Zn finger	514..535	CDD:275371	6/20 (30%)
ZBTB43	NP_001129248.1	BTB_POZ_ZBTB43	8..128	CDD:349536	27/165 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..153		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..225		13/105 (12%)
		C2H2 Zn finger	376..394	CDD:275368	3/26 (12%)
		C2H2 Zn finger	402..422	CDD:275368	6/24 (25%)
		zf-H2C2_2	414..437	CDD:404364	9/23 (39%)
		C2H2 Zn finger	430..447	CDD:275368	9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000