DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4020 and LYS2

DIOPT Version :9

Sequence 1:	NP_001259264.1	Gene:	CG4020 / 31522	FlyBaseID:	FBgn0029821	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_009673.1	Gene:	LYS2 / 852412	SGDID:	S000000319	Length:	1392	Species:	Saccharomyces cerevisiae

Alignment Length:	371	Identity:	76/371 - (20%)
Similarity:	123/371 - (33%)	Gaps:	144/371 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TIPEAFEDQE---------------IFVTGASGFVGKALIEKLLRSCPK--LGRIYVLMRPKKGH 49
            |:|.::..:|               :||||.:||:|..::..||...||  ..:::..:|.|...
Yeast   948 TLPSSYPSREYFVEPNSAEGKTTINVFVTGVTGFLGSYILADLLGRSPKNYSFKVFAHVRAKDEE 1012

  Fly    50 TIEERLQL------QWESRLYERLRREQPNARSKLVAIAGDVEQLGLGIGSADLERLRN-VNIVY 107
            ....|||.      .|..:.           .|.:..:.||:.:...|:.......|.| |:|:.
Yeast  1013 AAFARLQKAGITYGTWNEKF-----------ASNIKVVLGDLSKSQFGLSDEKWMDLANTVDIII 1066

  Fly   108 HSAASV---------RFDDALSTAILLNTRGTHELVKLALEWPKLKAFVHVSTT-----YSN--- 155
            |:.|.|         |..:.:||..:::.        .|:..||...||..::|     |.|
Yeast  1067 HNGALVHWVYPYAKLRDPNVISTINVMSL--------AAVGKPKFFDFVSSTSTLDTEYYFNLSD 1123

  Fly   156 -------PGVLEVEERVYPPLADWRTTIKLAETYDAEILDIFNLKYGNFQPNTYTFTKSLAEQVV 213
                   ||:||.:                         |:.|...|  ....|..:|..||.::
Yeast  1124 KLVSEGKPGILESD-------------------------DLMNSASG--LTGGYGQSKWAAEYII 1161

  Fly   214 NEYRDR-LPIFIFRPSIVVSTIEEPVPGWADNFNGPTGLLVACGVGILRSQNCD----------- 266
            ....:| |...|.||..|...          :.||              |.|.|
Yeast  1162 RRAGERGLRGCIVRPGYVTGA----------SANG--------------SSNTDDFLLRFLKGSV 1202

  Fly   267 -----PNI--VADFVPADIVARTLITSVYKFMGESKSRAKDSDLYV 305
                 |:|  ..:.||.|.|||.::.:       |.:..|:::|.|
Yeast  1203 QLGKIPDIENSVNMVPVDHVARVVVAT-------SLNPPKENELAV 1241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4020	NP_001259264.1	FAR-N_SDR_e	12..333	CDD:187547	73/346 (21%)
CG4020	NP_001259264.1	FAR_C	359..450	CDD:176924
LYS2	NP_009673.1	alpha_am_amid	7..1379	CDD:274582	76/371 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I2873
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S3219
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860