DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4020 and FarO

DIOPT Version :9

Sequence 1:	NP_001259264.1	Gene:	CG4020 / 31522	FlyBaseID:	FBgn0029821	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_652021.1	Gene:	FarO / 45707	FlyBaseID:	FBgn0023550	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	181/519 - (34%)
Similarity:	272/519 - (52%)	Gaps:	62/519 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EAFEDQEIFVTGASGFVGKALIEKLLRSCPKLGRIYVLMRPKKGHTIEERLQLQWESRLYERLRR 69
            |.|||.||||||.||.|||||:||||||| .:.|||||:||:|..|.|:||....::.::..|..
  Fly    11 EFFEDSEIFVTGGSGVVGKALVEKLLRSC-NVRRIYVLLRPRKQLTAEQRLVRLRQATVFHVLAV 74

  Fly    70 EQPNARSKLVAIAGDVEQLGLGIGSADLERLRNVNIVYHSAASVRFDDALSTAILLNTRGTHELV 134
            ::|....|:||:.|||...||||..:.::|::.|::|||.||:||||:.|..|:.||..||.|.:
  Fly    75 QKPEELDKIVAVPGDVSLPGLGIDPSMMQRMKGVSLVYHCAATVRFDEPLREAVRLNVGGTLEAL 139

  Fly   135 KLALEWPKLKAFVHVSTTYSNPGVLEVEERVYPPLADWRTTIKLA-ETYDAEILDIFNLKYGNFQ 198
            |.|...|:|:||:||||.||||.:..||.:.|....|||..:::. :..|..:|:....|.....
  Fly   140 KFAETLPQLRAFIHVSTFYSNPYLTRVEPKYYSSPMDWRLCLRMIDDVADDGMLNALTRKLIMGF 204

  Fly   199 PNTYTFTKSLAEQVVNEYRDRLPIFIFRPSIVVSTIEEPVPGWADNFNGPTGLLVACGVGILRSQ 263
            ||||||||:|||.:||:||.|||:.::|||||:..:|:|.||::.:..|..||....|.|||::.
  Fly   205 PNTYTFTKNLAESLVNDYRHRLPVIVYRPSIVLFAVEDPSPGFSPSLMGAMGLFALVGAGILKTV 269

  Fly   264 NCDPNIVADFVPADIVARTLITSVYKFMG-ESKSRAKDSDLYVVNCATANISPITMGEVIDIGKT 327
            ....:|..|..|.||..::::  .|..|| :...:...:||.|...::....|.|..::.:...|
  Fly   270 YLGKDIRLDITPQDIGIKSML--CYTKMGYDIYRQGPPADLPVFLSSSCTHVPHTFTQIAEQMDT 332

  Fly   328 --FIRKNPFEKTLWLPGGGMTTCPVLHFVRFCTMHLLMAIVVDTLLRLYNEKPFLMKLQRRIFAA 390
              ..|...|||.|.:||...|.....:.....|..:|.|:::|.|||::.:||.||...|:.:..
  Fly   333 LDLWRDVAFEKNLMIPGCHYTDKRWAYQFLVFTKQILPALILDLLLRIFGQKPVLMSAVRKAYQT 397

  Fly   391 FSALQVFAMTEW-------------HFQNDNFRALHDVVPANEVSNFGFMQHANINYTEFFQHG- 441
            ...:|.|....|             |.:...|             ||....|.:|       ||
  Fly   398 LEVMQPFMFNNWDSPGVSDMETLSKHGEGSAF-------------NFDAFNHPDI-------HGL 442

  Fly   442 --------IRGAKEFLLKESPESSSAAR--FRVKIFYVLDFLCRGIVYSFL-LRLIFRFLVRLW 494
                    :...:..||:|.|::...::  .|:|:|          :|..| |.|:::.::.||
  Fly   443 VIQSCSNMLHSIRTHLLREDPKTLERSKRILRIKVF----------LYRLLRLFLLYKLILWLW 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4020	NP_001259264.1	FAR-N_SDR_e	12..333	CDD:187547	133/324 (41%)
CG4020	NP_001259264.1	FAR_C	359..450	CDD:176924	22/112 (20%)
FarO	NP_652021.1	FAR-N_SDR_e	18..328	CDD:187547	131/312 (42%)
FarO	NP_652021.1	FAR_C	379..>410	CDD:296071	8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466735
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	9	8.850