DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4020 and CG8303

DIOPT Version :9

Sequence 1:	NP_001259264.1	Gene:	CG4020 / 31522	FlyBaseID:	FBgn0029821	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001286495.1	Gene:	CG8303 / 36858	FlyBaseID:	FBgn0034143	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	152/524 - (29%)
Similarity:	252/524 - (48%)	Gaps:	53/524 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTIPEAFEDQEIFVTGASGFVGKALIEKLLRSCPKLGRIYVLMRPKKGHTIEERLQLQWESRLYE 65
            :||||.|..:.|||||.:||:|..|||.||.:.|.:|.||||:|.|:.....||::...:..::|
  Fly    37 LTIPEFFAHKNIFVTGGTGFLGTVLIEALLDTHPDIGTIYVLVRGKRKFDPNERIRRLLQKPIFE 101

  Fly    66 RLRREQPNARSKLVAIAGDVEQLGLGIGSADLERL-RNVNIVYHSAASVRFDDALSTAILLNTRG 129
            :...:   ..||:|.:.|::.:...|.|...|:.| ..||::|||||:::|...|.|||..|..|
  Fly   102 KYSEK---TLSKVVPVVGELSEPNFGFGPELLQELIDRVNVIYHSAATIKFSSPLRTAIRTNLTG 163

  Fly   130 THELVKLALEWPKLKAFVHVSTTY---SNPGVLEVEERVYPPLADWRTTIKLAETYDAEILDIFN 191
            |...::||.:..:|.|:::.||.:   :|.|:  :.|.||....|....:|:||. |:...|..:
  Fly   164 TMRTIELAKQLKQLAAYIYCSTAFCNSNNRGL--IAEEVYKSQFDPYEMMKMAED-DSAWEDFTD 225

  Fly   192 LK---YGNFQPNTYTFTKSLAEQVVNEYRDRLPIFIFRPSIVVSTIEEPVPGWADNFN-GPTGLL 252
            .|   |....||||||||:|:|.::......||..|.|||||..|:|.|:.||..|.| |..|.|
  Fly   226 QKCKGYIRDHPNTYTFTKNLSENLLMAEMSGLPAAIVRPSIVYGTLEHPMKGWVGNANSGHLGFL 290

  Fly   253 VACGVGILRSQNCDPNIVADFVPADIVARTLITSVYKFMGESKSRAKDSDLYVVNCATANISPIT 317
            .....||.|:...:.|.|.|.:|.|.|..:.:...: ::|..|....:    :::|.:..::|:.
  Fly   291 AGFVKGIFRTMCGNANAVIDIIPCDYVINSSLVMGW-YVGTRKLEQPE----IIHCTSGEVNPLN 350

  Fly   318 MGEVIDIGKTFIRKNPFEKTLWLP-----GGGMTTCPVLHFVRFCTMHLLMAIVVDTLLRLYNEK 377
            :.|...|....:.::|....:|.|     .|....   |.|..|   |||.|:|.     :..||
  Fly   351 LAEFCTIINDSVERHPPNSFVWKPVTKLRNGWRYN---LFFYLF---HLLPAMVF-----IIPEK 404

  Fly   378 PFLMKLQR-------RIF-AAFSALQVFAMTEWHFQNDNFRALHDVVPANEVSNFGFMQHANINY 434
            .|.:.:.:       |:| ....|...|...::.:...|...:..::|.::...:.| ..:..::
  Fly   405 LFGIGMPQHTAYEYMRVFQKGTKAFDYFLDKDFRYSLKNALRISALIPESDRRRYNF-DASQCDW 468

  Fly   435 TEFFQHGIRGAKEFLLKESPESSSAARFRVKIFYVLDFLCRGIVYSFL---------LRLIFRFL 490
            :||....:.|.:.|..|||..::...|...|:|.||.:....::::.|         |::.....
  Fly   469 SEFIDRCLIGIRRFYFKESAVTTDWHRNYWKVFNVLYYAGYVVIFAVLYFALTLTLGLQIGLTLA 533

  Fly   491 VRLW 494
            |.:|
  Fly   534 VLIW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4020	NP_001259264.1	FAR-N_SDR_e	12..333	CDD:187547	109/328 (33%)
CG4020	NP_001259264.1	FAR_C	359..450	CDD:176924	19/98 (19%)
CG8303	NP_001286495.1	FAR-N_SDR_e	46..366	CDD:187547	109/330 (33%)
CG8303	NP_001286495.1	Sterile	392..485	CDD:281068	19/98 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466737
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.000