DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act5C and ACTR6

DIOPT Version :9

Sequence 1:	NP_001014725.1	Gene:	Act5C / 31521	FlyBaseID:	FBgn0000042	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_071941.1	Gene:	ACTR6 / 64431	HGNCID:	24025	Length:	396	Species:	Homo sapiens

Alignment Length:	415	Identity:	106/415 - (25%)
Similarity:	192/415 - (46%)	Gaps:	68/415 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VAALVVDNGSGMCKAGFAGDDA---PRAVFPSIVGRPRHQGVMVGMGQKDSYVG---DEAQSKRG 64
            :..||:|||:...|.|::.::.   |...|.|...|.:            ::..   ||.:...|
Human     1 MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLK------------TFTANQIDEIKDPSG 53

  Fly    65 ILTLKYPIEHGIVTNWDDMEKIWHHTFYNEL-RVAPEEHPVLLTEAPLNPKANREKMTQIMFETF 128
            :..: .|.:.|.:.|||...::|.:.|..|: :|...:..:::||...|..:.:|.|.:|:||.:
Human    54 LFYI-LPFQKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEY 117

  Fly   129 NTPAMYVAIQAVLSLYASGRTTG------------IVLDSGDGVSHTVPIYEGYALPHAILRLDL 181
            .       .||||.:.|...:..            |::|||...:|.||.........||:|:::
Human   118 Q-------FQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINV 175

  Fly   182 AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATA---ASSSSLEKSYEL 243
            .|:.||::|.:|::.|  ......|..::..:||.:|||:.||.::|..|   ...:::...|.|
Human   176 GGKLLTNHLKEIISYR--QLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVL 238

  Fly   244 PD------------------------GQVITIGNERFRCPEALFQPSFLGMEACGIHETTYNSIM 284
            ||                        .|::.:.||||..||.||.||.:|::..||.|....||.
Human   239 PDFSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVYSIQ 303

  Fly   285 KCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILAS 349
            ....:::...:.|.||:||.:::||..||:..|:..|.|:...:.::.|.......|.||.:::.
Human   304 NLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAWEGGKLISE 368

  Fly   350 LSTFQQMWISKQEYDESGPSIVHRK 374
            ...|:.|.:::::|:|:|.|:...|
Human   369 NDDFEDMVVTREDYEENGHSVCEEK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act5C	NP_001014725.1	PTZ00281	1..376	CDD:173506	106/415 (26%)
ACTR6	NP_071941.1	ACTIN	2..394	CDD:214592	106/414 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54227
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930