Protein Alignment Act5C and ACTL6B

DIOPT Version :9

• Sequence 1: NP_001014725.1
• Gene: Act5C / 31521
• FlyBaseID: FBgn0000042
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_057272.1
• Gene: ACTL6B / 51412
• HGNCID: 160
• Length: 426
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 158/428 - (36%)
• Similarity: 228/428 - (53%)
• Gaps: 67/428 - (15%)

  Fly     4 EEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVG--RPRHQGVMVGMGQKDS------------Y 54
            :||.|||.|.||...:||:||:|.|:|.||:.||  .....|.:...|.|:.            :
Human     9 DEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALH 73

  Fly    55 V---GDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKAN 116
            |   |.|..|         |:::|::.:|:....|..||:...::..|..||||::|||.|.:|.
Human    74 VPRDGAEVMS---------PLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAK 129

  Fly   117 REKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHT--VPIYEGYALPHAILRL 179
            |||:|::|||.:|.||.::...|||:.:|:||:||:||||  |.:||  :|:::||.|...|::.
Human   130 REKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDS--GATHTTAIPVHDGYVLQQGIVKS 192

  Fly   180 DLAGRDLTDYLMKILTERGYSFT---TTAEREIVRD-------IKEKLCYVA------------L 222
            .|||..::....::..|......   ..|.:|.||:       .||||..|:            .
Human   193 PLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQ 257

  Fly   223 DFEQEMATAASSSSLEK--------SYELPDGQVITIGNERFRCPEALFQPS----FLGMEACGI 275
            ||:..:...:.|...|:        .||:|:|.....|.||.|.||.||.||    ..|....|:
Human   258 DFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGV 322

  Fly   276 HETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIA---PPERK 337
            ......||..||:|||..||.:.:::||.|:..|..||:.:|::...|.:|::|:||   ..|||
Human   323 GHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERK 387

  Fly   338 YSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKC 375
            :|.||||||||||.||||||||||||:|.|...|.|||
Human   388 FSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKC 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Act5C	NP_001014725.1	PTZ00281	1..376	CDD:173506	158/428 (37%)
ACTL6B	NP_057272.1	Actin	11..426	CDD:394979	157/426 (37%)
		Essential for mediating its function in dendritic development, may contribute to neuronal-specific targeting. /evidence=ECO:0000250|UniProtKB:Q99MR0	39..82		8/42 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820