DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act5C and ACTL9

DIOPT Version :9

Sequence 1:	NP_001014725.1	Gene:	Act5C / 31521	FlyBaseID:	FBgn0000042	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_848620.3	Gene:	ACTL9 / 284382	HGNCID:	28494	Length:	416	Species:	Homo sapiens

Alignment Length:	373	Identity:	152/373 - (40%)
Similarity:	232/373 - (62%)	Gaps:	5/373 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLK 69
            :..|:|:|.|:|.||.||||..:|.....:|:|....:....|.....:::| ||......|||.
Human    48 KTGAVVIDMGTGTCKVGFAGQASPTYTVATILGCQPKKPATSGQSGLQTFIG-EAARVLPELTLV 111

  Fly    70 YPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMY 134
            .|:..|||.:||..|.||.|...::||||..:||:|.::.|.:|..||||:.::.||:..:||||
Human   112 QPLRSGIVVDWDAAELIWRHLLEHDLRVATHDHPLLFSDPPFSPATNREKLVEVAFESLRSPAMY 176

  Fly   135 VAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGY 199
            ||.|:|||:||.||.:|:|:|:|.||::|||:::||.|.||..||||||.:||.:|.::|.:.|.
Human   177 VASQSVLSVYAHGRVSGLVVDTGHGVTYTVPVFQGYNLLHATERLDLAGNNLTAFLAEMLLQAGL 241

  Fly   200 SFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQ 264
            .. ...:.::|.:||...||||.||::|.  |......:::.:||||:.:|:|.|.|:|||.||.
Human   242 PL-GQQDLDLVENIKHHYCYVASDFQKEQ--ARPEQEYKRTLKLPDGRTVTLGKELFQCPELLFN 303

  Fly   265 PSFL-GMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKI 328
            |..: |:...|:......|:.|..:::|.||..|.:|.||::::.|...|.:.|:....|:...:
Human   304 PPEVPGLSPVGLSTMAKQSLRKLSLEMRADLAQNVLLCGGSSLFTGFEGRFRAELLRALPAETHV 368

  Fly   329 KIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF 376
            .:.|.|.|.:||||||||||||..||..|:.:::|:|.||.||:|||:
Human   369 VVAAQPTRNFSVWIGGSILASLRAFQSCWVLREQYEEQGPYIVYRKCY 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act5C	NP_001014725.1	PTZ00281	1..376	CDD:173506	151/371 (41%)
ACTL9	NP_848620.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		NBD_sugar-kinase_HSP70_actin	49..416	CDD:302596	151/370 (41%)
		ACTIN	49..415	CDD:214592	150/369 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920