DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Act5C and alp5

DIOPT Version :9

Sequence 1:	NP_001014725.1	Gene:	Act5C / 31521	FlyBaseID:	FBgn0000042	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_595820.1	Gene:	alp5 / 2541318	PomBaseID:	SPBP23A10.08	Length:	433	Species:	Schizosaccharomyces pombe

Alignment Length:	439	Identity:	130/439 - (29%)
Similarity:	204/439 - (46%)	Gaps:	82/439 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTL 68
            :||:|:|:|.||...:.||:|:|.|:.|.||..|.......:.|    :.|:   .:|..| :.:
pombe     9 DEVSAIVIDPGSKWTRIGFSGEDIPKCVLPSYCGEFSDGRRLFG----EEYI---YKSNPG-MEI 65

  Fly    69 KYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAM 133
            |..|.:|.|.|||....:|.:....:|:..|.|||:|:||...||..||.|..:.|||:...||.
pombe    66 KNAIRNGWVENWDVTVDLWRYGLEQQLKTNPLEHPILITEPFDNPPENRVKTLETMFESLRCPAT 130

  Fly   134 YVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERG 198
            |:|.|...:.:|||:.|..::|.|...|....||:|:.|.........:|..:.|.|.:.|.::.
pombe   131 YLAKQETCAAFASGKGTACLVDIGAERSSVSAIYDGFVLQKGYQVQHFSGNAINDILAQTLRDKN 195

  Fly   199 Y-------------------------------SFTTTAEREIVRDIKEKLCYVA-LDFEQEMATA 231
            :                               |:.....:.:..:.||:...:: :.|..|...|
pombe   196 FEVMPKYLVKSKNPVEIGQPANCELRPRDTTDSYHQFQVQRVYDEWKEECALISDVPFSSETTIA 260

  Fly   232 ASSSSLEKSYELPDGQVITIGNERFRCPEALFQP-----------------------------SF 267
                  |..:|.|||..:..|.||::.||.||.|                             :.
pombe   261 ------ESEFEFPDGSRMMFGAERYQIPEHLFVPGSDEEMNEEPSKPIEQTENNEVSQQDSSVTN 319

  Fly   268 LGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIA 332
            ......||.:...|.|.:||||||..|..|.::.|||::..|.:.|:|.|::.|.|.: ::||.|
pombe   320 TSSRILGIPQLFQNCISECDVDIRASLLNNVIVCGGTSLMQGFSLRLQNELSKLYPGS-RLKIHA 383

  Fly   333 P---PERKYSVWIGGSILASLSTFQQMWISKQEYDESGP---SIVHRKC 375
            .   .||.|:.|:|||||:||.||.|:|||:|||:|.|.   :::.::|
pombe   384 SGHVVERSYASWLGGSILSSLGTFHQLWISRQEYEEHGSDRLALIEKRC 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Act5C	NP_001014725.1	PTZ00281	1..376	CDD:173506	130/439 (30%)
alp5	NP_595820.1	COG5277	6..425	CDD:227602	129/430 (30%)
alp5	NP_595820.1	Actin	11..433	CDD:278451	129/437 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810