DRSC/TRiP Functional Genomics Resources

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Protein Alignment Act5C and POTEH

DIOPT Version :9

Sequence 1:NP_001014725.1 Gene:Act5C / 31521 FlyBaseID:FBgn0000042 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_001129685.1 Gene:POTEH / 23784 HGNCID:133 Length:545 Species:Homo sapiens


Alignment Length:259 Identity:53/259 - (20%)
Similarity:100/259 - (38%) Gaps:55/259 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 IEHGIVTNWDDM--EKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMY 134
            :|||...|..|.  ....|:..|||.::..:  .:||..|.:..| |:..:|.::..........
Human   263 LEHGTDPNIPDEYGNTALHYAIYNEDKLMAK--ALLLYGADIESK-NKHGLTPLLLGVHEQKQQV 324

  Fly   135 V--AIQAVLSLYASGR--TTGIVLDSGDGVSHTVPIYEGYALPHAIL--RLDLAGRDLTDYLMKI 193
            |  .|:...:|.|..|  .|.::|....|.:..|.:         :|  .:|::.:||:..    
Human   325 VKFLIKKKANLNALDRYGRTALILAVCCGSASIVSL---------LLEQNIDVSSQDLSGQ---- 376

  Fly   194 LTERGYSFTT--TAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERF 256
             |.|.|:.::  ....:::.|.|||         |.:..::.:|:.|:..:|...:    .::|.
Human   377 -TAREYAVSSRHNVICQLLSDYKEK---------QILKVSSENSNPEQDLKLTSEE----ESQRL 427

  Fly   257 RCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITA 320
            :..|. .||..:..|.    |.......|.:.:::|        .|.|.|  |..:.:....||
Human   428 KGSEN-SQPEEMSQEP----EINKGGDRKVEEEMKK--------HGSTHM--GFPENLTNGATA 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Act5CNP_001014725.1 PTZ00281 1..376 CDD:173506 53/259 (20%)
POTEHNP_001129685.1 Ank_4 180..230 CDD:290365
ANK 1 180..208
ANK 204..329 CDD:238125 16/68 (24%)
ANK 2 209..238
ANK repeat 211..240 CDD:293786
Ank_2 214..306 CDD:289560 13/45 (29%)
ANK repeat 242..273 CDD:293786 4/9 (44%)
ANK 3 242..271 3/7 (43%)
ANK 270..394 CDD:238125 28/140 (20%)
ANK repeat 275..306 CDD:293786 8/33 (24%)
ANK 4 275..304 7/30 (23%)
Ank_2 280..372 CDD:289560 21/103 (20%)
ANK repeat 308..339 CDD:293786 5/30 (17%)
ANK 5 308..337 4/28 (14%)
ANK repeat 341..372 CDD:293786 6/39 (15%)
ANK 6 341..370 6/37 (16%)
ANK 7 374..404 8/43 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..524 17/90 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100127
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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