DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Act5C and POTEB2

DIOPT Version :9

Sequence 1:NP_001014725.1 Gene:Act5C / 31521 FlyBaseID:FBgn0000042 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_001264232.1 Gene:POTEB2 / 100287399 HGNCID:48327 Length:544 Species:Homo sapiens


Alignment Length:245 Identity:49/245 - (20%)
Similarity:99/245 - (40%) Gaps:48/245 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 EAQSKRGILTLKYPIEHGIVTNWDDM--EKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKM 120
            :.|....:|.|   :|||...|..|.  ....|:..|||.::..:  .:||..|.:..| |:..:
Human   178 QCQEDECVLML---LEHGADGNIQDEYGNTALHYAIYNEDKLMAK--ALLLYGADIESK-NKCGL 236

  Fly   121 TQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYA-LPHAIL--RLDLA 182
            |.::.      .::...|.|:......:.....||.....:..:.:..|.| :.:.:|  .:|::
Human   237 TPLLL------GVHEQKQEVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVNLLLEQNVDVS 295

  Fly   183 GRDLTDYLMKILTERGYSFTTTAE--REIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPD 245
            .:||:..     |.|.|:.::...  .|::.|.|||         |.:..::.:|:.|:..:|..
Human   296 SQDLSGQ-----TAREYAVSSHHHVICELLSDYKEK---------QMLKISSENSNPEQDLKLTS 346

  Fly   246 GQVITIGNERFRCPEALFQPSFLGMEACGIHETTYNSIMK-CDVDIRKDL 294
            .:    .::|.:..|. .||..:..|.         .|.| ||.::.:::
Human   347 EE----ESQRLKVSEN-SQPEKMSQEP---------EINKDCDREVEEEI 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Act5CNP_001014725.1 PTZ00281 1..376 CDD:173506 49/245 (20%)
POTEB2NP_001264232.1 ANK 130..255 CDD:238125 20/88 (23%)
ANK 1 135..167
ANK repeat 137..166 CDD:293786
ANK 2 168..200 7/24 (29%)
ANK repeat 168..199 CDD:293786 7/23 (30%)
ANK 196..320 CDD:238125 26/137 (19%)
ANK 3 201..233 8/34 (24%)
ANK repeat 201..232 CDD:293786 8/33 (24%)
ANK 4 234..266 4/37 (11%)
ANK repeat 234..265 CDD:293786 3/36 (8%)
ANK 5 267..299 4/31 (13%)
ANK repeat 267..298 CDD:293786 4/30 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..457 12/65 (18%)
SMC_N <412..>542 CDD:330553
CCDC144C 489..>542 CDD:317340
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100127
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

Return to query results.
Submit another query.