DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16721 and TCP11L1

DIOPT Version :9

Sequence 1:	NP_001284913.1	Gene:	CG16721 / 31520	FlyBaseID:	FBgn0029820	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_011518506.1	Gene:	TCP11L1 / 55346	HGNCID:	25655	Length:	514	Species:	Homo sapiens

Alignment Length:	511	Identity:	163/511 - (31%)
Similarity:	263/511 - (51%)	Gaps:	62/511 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QSGQSGDHEEHE-------------ERRIRTDSESSVESMTRFVLPSLDGTPPKIVTLDEVSSMF 61
            ::|:|..::..|             ::.|::|| ||.:.:.|   |  ..:||:.||::|:....
Human    12 EAGKSKSNDSEEGLEDAVEGADEALQKAIKSDS-SSPQRVQR---P--HSSPPRFVTVEELLETA 70

  Fly    62 KNLRNMELAHEIALNPDFKLQKYEPPSDSLEGAIKKMVHKAFWDLLRVQLDRQPPSYDQAIRLLA 126
            :.:.||.|||||.:|.||:::..|.|.:||:..:|::|||||||.|.|||...||:||.||:|:.
Human    71 RGVTNMALAHEIVVNGDFQIKPVELPENSLKKRVKEIVHKAFWDCLSVQLSEDPPAYDHAIKLVG 135

  Fly   127 EIKECFPQLLSPNNERALAHINEVLDDSVIRQQAERGTLDFRAYANFVINILSRSCSPARDEAVA 191
            ||||.....|.|.:.|....|.||||..:|:|:||.|.||....|.|:|.::...|:|||||.|.
Human   136 EIKETLLSFLLPGHTRLRNQITEVLDLDLIKQEAENGALDISKLAEFIIGMMGTLCAPARDEEVK 200

  Fly   192 ALRKIDDVVDTFRCILELMTLMKLDMANFMLRLARTEIAANSVQYEKEKFSKYLRE-----FHGN 251
            .|:.|.::|..||.|..::.|||:|||||.:...|..:...||:||::||.:.|..     |..:
Human   201 KLKDIKEIVPLFREIFSVLDLMKVDMANFAISSIRPHLMQQSVEYERKKFQEILERQPTLFFTDS 265

  Fly   252 VGF------PATEDWL-QRHR---------SGSSD-----DETIYN-AYMQLIDYP-ADKEFPEL 293
            :.|      .|:||.: |:::         :||.|     ...:.| ||::|:.:. ..:.|||.
Human   266 LDFVTQWLEEASEDLMTQKYKHALPVGGMAAGSGDMPRLSPVAVQNYAYLKLLKWDHLQRPFPET 330

  Fly   294 LRIDKERFAGLSWRAQRLILCAS--LISVAQGMPIISQRRENRIKLAQQLDIIVQDIK----NQD 352
            :.:|:.||..|..:.::|.:..:  |::.:...|.||.:.:...||...:.|::.|:.    :..
Human   331 VLMDQSRFHELQLQLEQLTILGAVLLVTFSMAAPGISSQADFAEKLKMIVKILLTDMHLPSFHLK 395

  Fly   353 QVASTI--ESCYEQIRSFVNKALEQENLPALSDADQAALKNQVLKLANKTSPVPSLMAKRLDGYV 415
            .|.:||  :.|.|     |:..|........:...:..||.|:..:|:...|:..:|..|:..::
Human   396 DVLTTIGEKVCLE-----VSSCLSLCGSSPFTTDKETVLKGQIQAVASPDDPIRRIMESRILTFL 455

  Fly   416 RVTLRSNGSIPPP--PSGFADYQEELVAFIASFRRLVSYNHAVFGEHFHQILNKTL 469
            ...|.|....|.|  |.|.:..|.||......|.|||:||..||..::..||:|.|
Human   456 ETYLASGHQKPLPTVPGGLSPVQRELEEVAIKFARLVNYNKMVFCPYYDAILSKIL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16721	NP_001284913.1	Tcp11	69..460	CDD:283456	142/428 (33%)
TCP11L1	XP_011518506.1	Tcp11	78..505	CDD:283456	142/431 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155536
Domainoid	1	1.000	212	1.000	Domainoid score	I2776
eggNOG	1	0.900	-	-		E1_KOG1981
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41260
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3424
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52848
OrthoDB	1	1.010	-	-		D1230328at2759
OrthoFinder	1	1.000	-	-		FOG0000982
OrthoInspector	1	1.000	-	-		otm40672
orthoMCL	1	0.900	-	-		OOG6_103214
Panther	1	1.100	-	-	O	PTHR12832
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3153
SonicParanoid	1	1.000	-	-		X1156
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800