DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16721 and Tcp11l1

DIOPT Version :9

Sequence 1:	NP_001284913.1	Gene:	CG16721 / 31520	FlyBaseID:	FBgn0029820	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_796164.1	Gene:	Tcp11l1 / 320554	MGIID:	2444263	Length:	509	Species:	Mus musculus

Alignment Length:	504	Identity:	169/504 - (33%)
Similarity:	258/504 - (51%)	Gaps:	48/504 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DAQENRSEQSGQSGDHE---EHEERRIRTDSESSVESMTRFVLPSLDGTPPKIVTLDEVSSMFKN 63
            :|:...||| |..|..|   |..::::::||.||    .|...|  ..:|.::||::|:....|.
Mouse    15 EAEAAASEQ-GLEGALECSDETLQKKVKSDSPSS----QRVGRP--HSSPARLVTVEELLETAKG 72

  Fly    64 LRNMELAHEIALNPDFKLQKYEPPSDSLEGAIKKMVHKAFWDLLRVQLDRQPPSYDQAIRLLAEI 128
            :.||.|||||.:..||::...|....|||..:|::|||||||.|.|||..:||:||.||:|:.||
Mouse    73 VTNMALAHEIVVTGDFRINAVELAEGSLEKRVKEIVHKAFWDCLSVQLSEEPPTYDHAIKLVGEI 137

  Fly   129 KECFPQLLSPNNERALAHINEVLDDSVIRQQAERGTLDFRAYANFVINILSRSCSPARDEAVAAL 193
            ||.....|.|.:.|....|.||||..:|:|:||.|.||....|.|:|.::...|:|||||.|..|
Mouse   138 KETLLSFLLPGHTRLRNQITEVLDLELIKQEAENGALDISKLAEFIIGMMGILCAPARDEEVKKL 202

  Fly   194 RKIDDVVDTFRCILELMTLMKLDMANFMLRLARTEIAANSVQYEKEKFSKYLREFHGNVGF---- 254
            :.|.::|..||.|..::.|||:|||||.:...|..:...||:||:.||.:.|.....::.|
Mouse   203 KGIKEIVPLFRAIFSVLDLMKVDMANFAISSIRPHLMQQSVEYERRKFQEVLERQPNSLDFATQW 267

  Fly   255 --PATEDWL-QRHR---------SGSSD-----DETIYN-AYMQLIDYP-ADKEFPELLRIDKER 300
              .||.|.| |:::         :||.|     ..::.| ||::|:.:. ..:.|||.:.:|:.|
Mouse   268 LEEATNDLLSQKYKHALPAGGGAAGSGDAPLLTPVSVQNFAYLKLLKWDHFQRPFPETVLMDQSR 332

  Fly   301 FAGLSWRAQRLILCAS--LISVAQGMPIISQRRENRIKLAQQLDIIVQDI-----KNQDQVASTI 358
            |..|..:.::|.:..:  |::.:...|.||...:...||...:..::.|:     ..:|.:||..
Mouse   333 FQELQLQLEQLAVLGAVLLVTFSTAAPGISGHADFAEKLKMMVKTLLTDMHLPSFHLEDALASIG 397

  Fly   359 ES-CYEQIRSFVNKALEQENLPALSDADQAALKNQVLKLANKTSPVPSLMAKRLDGYVRVTLRSN 422
            |. |.|     |:..|........|.|.:..||.|:..||:...|:..:|..|:..::...|.|.
Mouse   398 EKVCLE-----VSSCLSLCGSSPFSVAKETVLKGQIQALASPEDPIRRIMESRIFTFLETYLASG 457

  Fly   423 GSIPPP--PSGFADYQEELVAFIASFRRLVSYNHAVFGEHFHQILNKTL 469
            ...|.|  |.|....|:||......|.|||:||..||..::..||:|.|
Mouse   458 HQKPLPTVPGGLGPIQKELEEVAVKFVRLVNYNKMVFCPYYDAILSKLL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16721	NP_001284913.1	Tcp11	69..460	CDD:283456	144/423 (34%)
Tcp11l1	NP_796164.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		14/48 (29%)
Tcp11l1	NP_796164.1	Tcp11	78..502	CDD:368617	144/428 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845985
Domainoid	1	1.000	211	1.000	Domainoid score	I2788
eggNOG	1	0.900	-	-		E1_KOG1981
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41260
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3406
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52848
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000982
OrthoInspector	1	1.000	-	-		otm42745
orthoMCL	1	0.900	-	-		OOG6_103214
Panther	1	1.100	-	-	O	PTHR12832
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3153
SonicParanoid	1	1.000	-	-		X1156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790