DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16721 and Tcp11l2

DIOPT Version :9

Sequence 1:	NP_001284913.1	Gene:	CG16721 / 31520	FlyBaseID:	FBgn0029820	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_666120.1	Gene:	Tcp11l2 / 216198	MGIID:	2444679	Length:	517	Species:	Mus musculus

Alignment Length:	509	Identity:	159/509 - (31%)
Similarity:	256/509 - (50%)	Gaps:	57/509 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DAQENRSEQSGQSGDHEEHEERRIRTDSESSVESMTRFVLPSLDGTPPKIVTLDEVSSMFKNLRN 66
            |::.:|..:...|....|...:...:||.|...|      |: ..:||:.:..|:|.:..|||.:
Mouse    17 DSESSRFAEGVASLSDYECSRQSFTSDSSSKSSS------PA-STSPPRGLMFDDVMAAAKNLSD 74

  Fly    67 MELAHEIALNPDFKLQKYEPPSDSLEGAIKKMVHKAFWDLLRVQLDRQPPSYDQAIRLLAEIKEC 131
            |.||||||:|.:|:|::...|.:||.|.:|::||:||||:|...|..:||.|:.||:|..||:|.
Mouse    75 MTLAHEIAVNENFQLKQNALPENSLAGQVKRVVHQAFWDVLEADLSAEPPQYEYAIKLFEEIREI 139

  Fly   132 FPQLLSPNNERALAHINEVLDDSVIRQQAERGTLDFRAYANFVINILSRSCSPARDEAVAALRKI 196
            ....|:|...|..:.|.||||..:||||||...:|.:..||:||..:.:.|:|.|||.:..|:..
Mouse   140 LLSFLTPGGNRLHSQICEVLDIDLIRQQAEHSAVDIQGLANYVITTMGKICAPVRDEDIRELKAT 204

  Fly   197 DDVVDTFRCILELMTLMKLDMANFMLRLARTEIAANSVQYEKEKFSKYLREFHGNVGFPATEDWL 261
            .::|:..|.|..::.||::||.||::|..|..|..:.|:||:.||.:.:.|...  ....|.:||
Mouse   205 TNIVEMLRQIFRVLDLMRMDMMNFVIRNIRPHIQHHLVEYERNKFQEVVEETPN--ALSQTTEWL 267

  Fly   262 QRHRSGSSDDE-----------------------TIYNAYMQLIDYPADKE-FPELLRIDKERFA 302
            :.    |.|.|                       .:.|.|::|:.:...|: .||.|..|..|..
Mouse   268 KE----SIDKELLSETDVAPAAEHSSTPSLSPLLVLNNCYLKLLQWDYQKKVLPETLMTDGPRLQ 328

  Fly   303 GLSWRAQRLIL--CASLI------SVAQGMPIISQRRENRIKLAQQLDIIVQDIKNQD--QVAST 357
            .||.:..:|.:  |.:||      :|.:|:|.::    ||:|   ::..::.:..|::  .:...
Mouse   329 ELSEKLNQLKMTACVALITNNMVGAVTEGLPELA----NRLK---RISAVLLEGMNKETFNLKEA 386

  Fly   358 IESCYEQIRSFVNKALEQENLPALSDADQAALKNQVLKLANKTSPVPSLMAKRLDGYVRVTL--- 419
            :.|...|..:.||||||:...|.|:...||.|..|:..|..|.:||.:||.||:..|::..|
Mouse   387 LHSIGVQTCAEVNKALEERGSPTLNAEVQANLVGQLSSLEEKDNPVCTLMDKRIQLYMKGLLCLP 451

  Fly   420 RSNGSIPPPPSGFADYQEELVAFIASFRRLVSYNHAVFGEHFHQILNKTLPGEE 473
            .:..|:||.|.|....|.||......:..:|:.|..|:|..:..|..|.|..:|
Mouse   452 STQKSMPPVPGGLDVIQRELEVLGCQYANIVNLNKQVYGPFYANIFRKLLFRDE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16721	NP_001284913.1	Tcp11	69..460	CDD:283456	138/427 (32%)
Tcp11l2	NP_666120.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		11/48 (23%)
Tcp11l2	NP_666120.1	Tcp11	77..495	CDD:283456	138/430 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845984
Domainoid	1	1.000	211	1.000	Domainoid score	I2788
eggNOG	1	0.900	-	-		E1_KOG1981
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3406
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52848
OrthoDB	1	1.010	-	-		D1230328at2759
OrthoFinder	1	1.000	-	-		FOG0000982
OrthoInspector	1	1.000	-	-		otm42745
orthoMCL	1	0.900	-	-		OOG6_103214
Panther	1	1.100	-	-	O	PTHR12832
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3153
SonicParanoid	1	1.000	-	-		X1156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800