Protein Alignment Usp30 and USP3

DIOPT Version :9

• Sequence 1: NP_001284912.1
• Gene: Usp30 / 31519
• FlyBaseID: FBgn0029819
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_006528.2
• Gene: USP3 / 9960
• HGNCID: 12626
• Length: 520
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 118/587 - (20%)
• Similarity: 186/587 - (31%)
• Gaps: 251/587 - (42%)

  Fly     3 SEKILMAAGVTVAAVVGAFVFWGPSGSRLRQRRGQIAGLHNFGLTCFLNTLLQAMAACPQFIAW- 66
            :.|:|...|.|.|...                    .||.|.|.|||:|.:||:::...||..:
Human   143 NSKLLKVNGSTTAICA--------------------TGLRNLGNTCFMNAILQSLSNIEQFCCYF 187

  Fly    67 -----LQLYNNASPDRKSLITSML--NTLEVVNGTHATL----RGD--PYSPGAVLRALNALGW- 117
                 ::|.|..:..|::..|...  |.:.:|.....||    :|.  .:||.::...:    |
Human   188 KELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVV----WK 248

  Fly   118 VIPQ----EEHDAHELFHVLLTCLEEEAIRPQPLGCLSDALPTDNDDNSSLAGTATPVGGFRSFS 178
            ::|.    ::.||||....||..|..|.                             .|||...|
Human   249 IMPNFRGYQQQDAHEFMRYLLDHLHLEL-----------------------------QGGFNGVS 284

  Fly   179 SMAAGLGASQRIGDQPNRPSSAMLTDFLNMEYDESTSLQRLVRSEAHTPDSPASVCERDGNDRLG 243
                               .||:|        .|:::|            |.::.|
Human   285 -------------------RSAIL--------QENSTL------------SASNKC--------- 301

  Fly   244 SVLLDAVSPGTPFGFPLVSNPDSLATPMLGGERSSRPRLPQSQQQQDEGLNRRVSSSCRSLERLH 308
                            .::...::.|.:.||
Human   302 ----------------CINGASTVVTAIFGG---------------------------------- 316

  Fly   309 RGPGRVSIWSNMMPSQVAHPFQGAMGAQIVCNGCGSKSAVRYDKFDSITLNLPPQRRTG------ 367
                   |..|                ::.|..||::|. ::|.|..::|::|.|.|:.
Human   317 -------ILQN----------------EVNCLICGTESR-KFDPFLDLSLDIPSQFRSKRSKNQE 357

  Fly   368 ----LSLGHLLSEYITSEDLSDVK---CDSCNETTTHTKSVTFAKLPACLCIHVARTVWLPTGQV 425
                .||...|..:...|:|.:.:   |..|.:....||.....|||..||:|:.|..|  |..:
Human   358 NGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHW--TAYL 420

  Fly   426 CKRKD-YVHFP-ESLSMAPYSFVQPHLNSQAGTPWGSTMSLYSSSLPMNNGVGGGEGFGTMFPKN 488
            ..:.| ||.|| ..|.|..|...                       |.|:|           |::
Human   421 RNKVDTYVEFPLRGLDMKCYLLE-----------------------PENSG-----------PES 451

  Fly   489 -LYRLLAVVVHSGE-ANSGHFVTYRRGSLRNAHRWYYTSDTIVREVSIDEVLSVPAYLLFYDRGQ 551
             ||.|.|||||.|. ..|||:..|    ..:..||::.:|:.|.....:.|:...||:|||...|
Human   452 CLYDLAAVVVHHGSGVGSGHYTAY----ATHEGRWFHFNDSTVTLTDEETVVKAKAYILFYVEHQ 512

  Fly   552 QR 553
            .:
Human   513 AK 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp30	NP_001284912.1	Peptidase_C19	39..>139	CDD:271592	32/118 (27%)
		UCH	<304..547	CDD:278850	63/259 (24%)
		Peptidase_C19F	<323..548	CDD:239127	62/241 (26%)
USP3	NP_006528.2	zf-UBP	29..105	CDD:307999
		UCH	159..508	CDD:306860	110/543 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810