Protein Alignment Usp30 and USP30

DIOPT Version :10

• Sequence 1: NP_572274.1
• Gene: Usp30 / 31519
• FlyBaseID: FBgn0029819
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: XP_016875537.1
• Gene: USP30 / 84749
• HGNCID: 20065
• Length: 554
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 171/646 - (26%)
• Similarity: 241/646 - (37%)
• Gaps: 254/646 - (39%)

  Fly    11 GVTVAAVVGAFVFWGPSGSRLRQRRGQIAGLHNFGLTCFLNTLLQAMAACPQFIAWLQLYNN--- 72
            |:..|...|.:|.|||...|.::|:|.:.||.|.|.|||:|:|||.::|||.||.||:.:.:
Human    40 GIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYS 104

  Fly    73 ----ASPDRKSLITSMLNTLEVVNGTHATLRGDPYSPGAVLRALNALGWVIPQ-EEHDAHELFHV 132
                ..|..:.|..::|:.|:.::....| ..:......:|..|....|.|.. ||.||||||||
Human   105 RDQKEPPSHQYLSLTLLHLLKALSCQEVT-DDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHV 168

  Fly   133 LLTCLEEEAIRPQPLGCLSDALPTDNDDNSSLAGTATPVGGFRSFSSMAAGLGASQRIGDQPNRP 197
            :.:.||:
Human   169 ITSSLED---------------------------------------------------------- 175

  Fly   198 SSAMLTDFLNMEYDESTSLQRLVRSEAHTPDSPASVCERDGNDRLGSVLLDAVSPGTPFGFPLVS 262
                                                 |||...|: :.|.|.
Human   176 -------------------------------------ERDRQPRV-THLFDV------------- 189

  Fly   263 NPDSLATPMLGGERSSRPRLPQSQQQQDEGLNRRVSSSCRSLERLHRGPGRVSIWSNMMPSQVAH 327
                                 .|.:||.|...:::  :||:     ||....:  ||...||  |
Human   190 ---------------------HSLEQQSEITPKQI--TCRT-----RGSPHPT--SNHWKSQ--H 222

  Fly   328 PFQGAMGAQIVCNGCGSKSAVRYDKFDSITLNLP------PQRRTGLSLGHLLSEYITSEDLSDV 386
            ||.|.:.:.:||..|..:|.||:|.|||::|::|      |     |:|.|.|..:|:||.:.||
Human   223 PFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHP-----LTLDHCLHHFISSESVRDV 282

  Fly   387 KCDSC---------------NETTTHTKSVTFAKLPACLCIHVARTVWLPTGQVCKRKDYVHFPE 436
            .||:|               ::.||..|.:...|||.|||||:.|..|...|...||.::|.|.|
Human   283 VCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNE 347

  Fly   437 SLSMAPYSF---------VQPHLNSQAG------------TPW--------GSTMSLYSSSL--- 469
            .|.|..|.:         ..|.||...|            ||.        ....|...|||
Human   348 FLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPGVCARGADAAGIFSTEKSSLASP 412

  Fly   470 PMNNGVGGGEGFGTMF-----PKN-----------------------------------LYRLLA 494
            |..:.:.|.:|...:.     ||.                                   |:||:|
Human   413 PSGSLMTGAQGLYNVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMA 477

  Fly   495 VVVHSGEANSGHFVTYRRG--SLRN----AHRWYYTSDTIVREVSIDEVLSVPAYLLFYDR 549
            ||||.|:.:|||||||||.  |.||    :::|.:.||..||:.|:.||||..||||||:|
Human   478 VVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYER 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp30	NP_572274.1	Peptidase_C19	39..>139	CDD:470612	38/107 (36%)
		Peptidase_C19F	<323..548	CDD:239127	104/323 (32%)
USP30	XP_016875537.1	Peptidase_C19F	69..537	CDD:239127	159/614 (26%)
		UBP12	<69..>265	CDD:227847	74/342 (22%)