DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp30 and USP27X

DIOPT Version :9

Sequence 1:	NP_001284912.1	Gene:	Usp30 / 31519	FlyBaseID:	FBgn0029819	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001138545.1	Gene:	USP27X / 389856	HGNCID:	13486	Length:	438	Species:	Homo sapiens

Alignment Length:	429	Identity:	101/429 - (23%)
Similarity:	145/429 - (33%)	Gaps:	130/429 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 RSFSSMAAGLGASQRIGDQPNRPSSAMLTDFLNMEYDESTSLQRLVRSEAHTPD------SPASV 233
            |..||...||.....:|:          |.|:|.          :|::..|||.      |....
Human    68 RITSSFTIGLRGLINLGN----------TCFMNC----------IVQALTHTPILRDFFLSDRHR 112

  Fly   234 CERDGNDRLGSVLLDAVSPGTPFGFPLVSNPDSLATPMLGGERSSRPRLPQS------------- 285
            ||....:                 ..||....||...:..|..|  |.:|..
Human   113 CEMPSPE-----------------LCLVCEMSSLFRELYSGNPS--PHVPYKLLHLVWIHARHLA 158

  Fly   286 ---QQQQDEGLNRRVSSSCRSLERLHR-----GPGRVSIWSNMMPSQVAHPFQGAMGAQIVCNGC 342
               ||...|.|       ..:|:.|||     ..|:.:...|.....:...|.|.:.:.:.|..|
Human   159 GYRQQDAHEFL-------IAALDVLHRHCKGDDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQAC 216

  Fly   343 GSKSAVRYDKFDSITLNLP----------PQRRTGL----------SLGHLLSEYITSEDL---S 384
            ...|.. .|....|:|:||          |.|.:.:          :|...|..:...|.|   :
Human   217 HGVSTT-IDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSA 280

  Fly   385 DVKCDSCNETTTHTKSVTFAKLPACLCIHVARTVWLPTGQVCKRK--DYVHFPESLSMAPY--SF 445
            .:||.||......||.:|..|||...|.|..|   .......:||  .|:.||..|.|.|:  |.
Human   281 KIKCGSCQSYQESTKQLTMNKLPVVACFHFKR---FEHSAKQRRKITTYISFPLELDMTPFMASS 342

  Fly   446 VQPHLNSQAGTPWGSTMSLYSSSLPMNNGVGGGEGFGTMFPKNLYRLLAVVVHSGEANSGHFVTY 510
            .:..:|.|.             .||.|:|..          :|.|.|.|||.|.|...|||:.::
Human   343 KESRMNGQL-------------QLPTNSGNN----------ENKYSLFAVVNHQGTLESGHYTSF 384

  Fly   511 RRGSLRNAHRWYYTSDTIVREVSIDEVLSVPAYLLFYDR 549
            .|   .:..:|:...|.::.:.||.:||....|||||.:
Human   385 IR---HHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHK 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp30	NP_001284912.1	Peptidase_C19	39..>139	CDD:271592
		UCH	<304..547	CDD:278850	71/274 (26%)
		Peptidase_C19F	<323..548	CDD:239127	66/251 (26%)
USP27X	NP_001138545.1	Peptidase_C19D	78..419	CDD:239125	95/416 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810