DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp30 and Usp49

DIOPT Version :9

Sequence 1:	NP_001284912.1	Gene:	Usp30 / 31519	FlyBaseID:	FBgn0029819	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001129942.1	Gene:	Usp49 / 316211	RGDID:	1310513	Length:	685	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	121/590 - (20%)
Similarity:	190/590 - (32%)	Gaps:	236/590 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SGSRLRQRRGQIA------GLHNFGLTCFLNTLLQAMAACPQFIAWLQLYNNASPDRKSLITSML 85
            |.:.|:.|| |:|      ||.|.|.||::|::||.::...:|   .:.:.|..|.     ||..
  Rat   233 SAAALKPRR-QLAVAPGVTGLRNLGNTCYMNSILQVLSHLQKF---RECFLNLDPS-----TSEH 288

  Fly    86 NTLEVVNG--------THATLRG-----------DP----YSPGA-VLRALNALGWVIPQEE--- 123
            ...:..||        ..:|..|           :|    :|.|| :.|:|..:....|..:
  Rat   289 LFPQATNGKAQIPSRPASSTAAGFSVRSDRAQGFEPQGFCWSSGASISRSLELIQNKEPSSKHIS 353

  Fly   124 --HDAHELFHVLLTCLEEEAIRPQPLGCLSDALPTDNDDNSSLAGTATPVGGFRSFSSMAAGLGA 186
              |:.|.||.|:                              .:|....|..|....|:.:.:.|
  Rat   354 LCHELHTLFRVM------------------------------WSGKWALVSPFAMLHSVWSLIPA 388

  Fly   187 SQRIGDQPNRPSSAMLTDFLNMEYDESTSLQRLVRSEAHTPDSPASVCERDGNDRLGSVLLDAVS 251
            .:                    .||:.              |:...:||          ||..|
  Rat   389 FR--------------------GYDQQ--------------DAQEFLCE----------LLHKV- 408

  Fly   252 PGTPFGFPLVSNPDSLATPMLGGERSSRPRLPQSQQQQDEGLNRR--VSSSCRSLERLHRGPGRV 314
                                             .|:.:.||..||  :..|.|.|
  Rat   409 ---------------------------------QQELESEGSTRRILIPFSQRKL---------- 430

  Fly   315 SIWSNMMPSQVAHPFQGAMGAQIVCNGCGSKSAVRYDKFDSITLNLP-----------PQRRTGL 368
               :..:...|...|.|.:.:|:.|..|..||.. .:.|..::|..|           |..:|..
  Rat   431 ---TKQVLKVVNTIFHGQLLSQVTCVSCNYKSNT-IEPFWDLSLEFPERYHCVEKGFVPLNQTEC 491

  Fly   369 SLGHLLSEYITSEDLSD--VKCDSCNETTTHT-----------KSVTFAKLPACLCIHVARTVWL 420
            .|..:|:::..:|.|..  ..||.||.....:           |.:...:||..|.:|:.|..|
  Rat   492 LLTEMLAKFTETEALEGRIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRW- 555

  Fly   421 PTGQVCKRKDYVH--FPESLSMAPYSFVQPHLNSQAGTPWGSTMSLYSSSLPMNNGVGGGEGFGT 483
             :|:..:.|..||  |.:.|:|.||.             .|..:    |||..:...
  Rat   556 -SGRNHREKIGVHVVFDQVLTMEPYC-------------CGDML----SSLDKDTFA-------- 594

  Fly   484 MFPKNLYRLLAVVVHSGEA-NSGHFVTY---RRGSLRNAHRWYYTSDTIVREVSIDEVLSVPAYL 544
                  |.|.|||:|.|:. .|||:..|   ..|..     |.:.:|:.:...|::||....||:
  Rat   595 ------YDLSAVVMHHGKGFGSGHYTAYCYNTEGGF-----WVHCNDSKLDVCSVEEVCKTQAYI 648

  Fly   545 LFYDR 549
            |||.|
  Rat   649 LFYTR 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp30	NP_001284912.1	Peptidase_C19	39..>139	CDD:271592	31/134 (23%)
		UCH	<304..547	CDD:278850	62/272 (23%)
		Peptidase_C19F	<323..548	CDD:239127	62/254 (24%)
Usp49	NP_001129942.1	zf-UBP	26..87	CDD:396634
Usp49	NP_001129942.1	UCH	250..651	CDD:395355	112/568 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810