DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mof and Kat6b

DIOPT Version :9

Sequence 1:	NP_511051.1	Gene:	mof / 31518	FlyBaseID:	FBgn0014340	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	XP_038949635.1	Gene:	Kat6b / 688634	RGDID:	1566399	Length:	2039	Species:	Rattus norvegicus

Alignment Length:	710	Identity:	205/710 - (28%)
Similarity:	302/710 - (42%)	Gaps:	155/710 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 TEDEPSSDTVICVADINPY-GSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAA 244
            |.||.|         :|.: |.||           |.....|:|.|.|:..|....:.....||.
  Rat   358 TSDEGS---------VNAFTGRGS-----------PGRGQKTKVCTTPSSGHAASGKDSSSRLAV 402

  Fly   245 PPPPPPPPAAEQVPETP-----------------------ASPTDDGEEP--PAVYLSPYIRSRY 284
            ..|..|....:....:.                       .:|:.||...  ..:..|.:.|.|.
  Rat   403 TDPTRPGATTKTTTSSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPRK 467

  Fly   285 MQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDDA 349
            .........:.:......|:..|||: .||....:|....:....|:.|||:..........:.:
  Rat   468 KVSQKQSCTSHMLATGTTQKLKPPPS-ALPPPAPISGQSPSSQKSSTSTSSAPTQSSSSRSSEPS 531

  Fly   350 LT--------------MEHDNTSRETVITTGDP-------LMQKIDISENPD-KIYFIRRED--- 389
            .:              :.|..|::......|.|       :.:|.:.|.... |..|..:.|
  Rat   532 FSSLINSSQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTEFSSTAKAKACFFGKRDFRS 596

  Fly   390 ---------GTVHRGQVLQS-----RTTENAAAPDEYYVHYVGLNRRLDGWVGRHRISDNADDLG 440
                     ..:.||.:.::     |||                      ::.:||:      ||
  Rat   597 RFLSHSSCSWGMTRGHIFKAIAHFKRTT----------------------FLKKHRM------LG 633

  Fly   441 GITVLPAPPLAPDQPSTSREMLA-------QQAAAAAAASSERQKR----AANKDYYLSYCENSR 494
            .:.....|.:.  .||..:..||       |........|.:::..    ..|||...
  Rat   634 RLKYKVTPQMG--TPSPGKGSLADGRINPDQDNDTEIKISIKQESMDVNVMGNKDLVT------- 689

  Fly   495 YDYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFS 559
                            :|...|.|...||:..:...|...|...  :|...::||.|||.|||.|
  Rat   690 ----------------EEDLDVFKQAQELSWEKIECESGVEDCG--RYPSVIEFGKYEIQTWYSS 736

  Fly   560 PFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYC 624
            |:|:||.:...||:||:|||||:.::....|..:|....||..||||:.::|::||:|....:||
  Rat   737 PYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYC 801

  Fly   625 QLLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQR 689
            |.|||:||||||||.||:|::|||||:|.:.|::|.|:||||||||...:.|||:||:::|.|||
  Rat   802 QNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQR 866

  Fly   690 KGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEM 754
            :|||:.||.|||.|||:||..|||||||||||||||.:||...:||.: .|.....|:||.:|..
  Rat   867 QGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYL-YRHHERHISIKAISRA 930

  Fly   755 SGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQ-LPQFKQPKLTIDTDYLVWSP 813
            :|:...||..|||.:.||....|:.||....|.|..|:: |....:|. .:|.:.|.|:|
  Rat   931 TGMCPHDIATTLQYLHMIDRRDGRFVIIRREKLILGHMEKLKNCSRPN-EVDPESLRWTP 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mof	NP_511051.1	Tudor-knot	382..432	CDD:288553	8/66 (12%)
		NAT_SF	528..813	CDD:302625	136/285 (48%)
		MOZ_SAS	599..778	CDD:280097	98/178 (55%)
Kat6b	XP_038949635.1	H15	94..168	CDD:197772
		PHD1_MOZ_MORF	213..270	CDD:277090
		PHD2_KAT6A_6B	272..318	CDD:277002
		PLN00104	<721..989	CDD:215056	133/269 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920