DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mof and enok

DIOPT Version :9

Sequence 1:	NP_511051.1	Gene:	mof / 31518	FlyBaseID:	FBgn0014340	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_001286823.1	Gene:	enok / 37859	FlyBaseID:	FBgn0034975	Length:	2291	Species:	Drosophila melanogaster

Alignment Length:	808	Identity:	218/808 - (26%)
Similarity:	346/808 - (42%)	Gaps:	221/808 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PEPEPEQPQQQQQEEKKEDGQDQ----VKSPGPVELEAQEPAQPQKQKEVVDQEIETED--EPSS 187
            |:.:|:.|.:.:...|:  |.|.    .|....:::||:......|......|.|:.:.  |..|
  Fly   279 PDKKPKHPYRCKTCSKQ--GFDTPKLVKKDNSRIKMEAERMTPSYKYASNKRQSIKKDGNIESPS 341

  Fly   188 DTVICVADINPYGSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAAPPPPPPPP 252
            .:.:||     |..|:.
  Fly   342 TSKLCV-----YNDGNG------------------------------------------------ 353

  Fly   253 AAEQVPETPASPTDDGEEPPAVYLSPYIRSRYMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQT 317
            ...:||.:.:|...:..|....:.|...||:.:|..      .||.::.|:|..
  Fly   354 QRRKVPASLSSRKMNHSEDQFEFPSKQKRSQILQGG------YLASQETRKRTF----------- 401

  Fly   318 VLSANVEAISDDSSETSSSDDDEEEEEDEDDALTMEHDN-----TSRETVITT---GDPLMQKID 374
                      .|.|.||||.:.|:|::::||......||     ||.::..::   .|......|
  Fly   402 ----------SDLSSTSSSSESEDEDDEDDDRNRNGDDNDQDESTSSDSCTSSSSDSDSSESSSD 456

  Fly   375 ISENPDKIYFIRRED-----GTVHRGQVLQS--------RTTENAAAPDEYYVHYVGLNRRL--D 424
            .||..|:  :...||     .|:....|.:|        .|.:...:|.         |..|  :
  Fly   457 TSEWDDE--YDEEEDYDTDRSTIREKNVFESGKQSCAKLSTGDGLGSPQ---------NNELGSE 510

  Fly   425 GW----VGRHRI-----SDNADDLGGI--------TVLPAP---------PLAPDQPSTSREMLA 463
            .|    |.::.|     |.:..::.||        |...:|         |:|...|..:...:.
  Fly   511 NWGFAAVAKNPIDIFVKSKHNSNVKGIGYSKPAASTFATSPAANRVQKSTPVASSTPEKNSAPIG 575

  Fly   464 QQAAAAAAASSERQK--------RAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDEINHVQKSH 520
            ........|:.:::|        ..|.|.|  ..||:.....::..:.:.|  ..:||...:::|
  Fly   576 GMTIKRQTANGQKKKIVPLKSMPLEAGKSY--EKCEDDIPYLTEETVMKVQ--LLEEIERSRETH 636

  Fly   521 AE--------------------------------LTATQAALEKE--HESITKI--KYIDK---- 545
            ::                                :|||...|.:|  |:::.::  .:|:|
  Fly   637 SQADGKREMNNDEDAPGESTKRANPFENQPLPPGVTATDVELYQEVLHKAVVQMSNNHIEKVNDV 701

  Fly   546 -------------LQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRR 597
                         :|.|.::|:|||.||||:||.:...|::||:||||.:.||....|.::|..:
  Fly   702 SLKSGQNTQSPKSIQIGKWDIETWYSSPFPQEYARLLKLFLCEFCLKYTKSRSVLDRHQNKCIWK 766

  Fly   598 RPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHI 662
            :|||.||:|:||||::||:|....:|||.|||:||.|||||.||:|::|||||||.:.|:.|.|:
  Fly   767 QPPGTEIFRQGNISVFEVDGNVNKIYCQNLCLLAKFFLDHKTLYYDVEPFLFYILTKNDQSGCHL 831

  Fly   663 VGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRS 727
            ||||||||...:.|||:|||.:|.:||:|:|:.||.|||.|||:||.:|:|||||||||||||.|
  Fly   832 VGYFSKEKHCTQKYNVSCILTMPQYQRQGYGRFLIDFSYLLSREEGQLGTPEKPLSDLGRLSYFS 896

  Fly   728 YWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQ-------NVICVTS 785
            ||...:||.:.......:||.|:::..:|:...||....:.:..||..|..       ||.....
  Fly   897 YWKSVVLEYLYKHRNYTKITFKDIAIKTGLAISDIALAFELLNFIKLRKNDGDIRYQINVKIEWK 961

  Fly   786 KTIQDHLQLPQFKQPKLTIDTDYLVWSP 813
            |.:..|.::...| .::.|:.|.|.|||
  Fly   962 KVLAHHNKMANSK-TRIIIEPDCLRWSP 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mof	NP_511051.1	Tudor-knot	382..432	CDD:288553	11/68 (16%)
		NAT_SF	528..813	CDD:302625	133/312 (43%)
		MOZ_SAS	599..778	CDD:280097	96/178 (54%)
enok	NP_001286823.1	H15	95..152	CDD:294056
		PHD_SF	183..>215	CDD:304600
		PHD	248..292	CDD:214584	3/12 (25%)
		NAT_SF	713..989	CDD:302625	130/277 (47%)
		MOZ_SAS	768..947	CDD:280097	96/178 (54%)
		Ehrlichia_rpt	<1150..>1539	CDD:118064
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850