DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mof and lsy-12

DIOPT Version :9

Sequence 1:	NP_511051.1	Gene:	mof / 31518	FlyBaseID:	FBgn0014340	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_001263849.1	Gene:	lsy-12 / 3565873	WormBaseID:	WBGene00045419	Length:	1585	Species:	Caenorhabditis elegans

Alignment Length:	896	Identity:	216/896 - (24%)
Similarity:	342/896 - (38%)	Gaps:	217/896 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SAGHVQEQPIEEEHEPEQEPTDAYTIGGPPRTPVEDAAAELSASLD--------VSGSDQ---SA 64
            |...::.:|::.:::...:|       ||...||       ||..|        :....|   |.
Worm    61 SLERIKREPVDTDYDDPNQP-------GPSSVPV-------SARTDHVLPIRFKIKAEPQEYDSD 111

  Fly    65 EQSLDLSGVQAEAAAESEPPAKRQHRDISPISEDSTPASSTSTSSTRSSSSSR---YDDVSEAEE 126
            |...|...||   .|..|.||      ||||.|    .|.......|.:.:::   :..||..:
Worm   112 EYGKDHGAVQ---IANKEVPA------ISPIEE----VSQKRRGRPRKTDAAQHLFFPHVSIKQ- 162

  Fly   127 APPEPE--------------PEQPQQQQQEEKKEDGQDQVKSPGPVELEAQEPAQPQKQKEVVDQ 177
               ||:              .:.|:.|...:..|....::    .:..|.::..:.:|:|
Worm   163 ---EPDDGFINFHESRCVGIAQDPEMQHLHDVNESHSSEI----AIFRETKKITERKKKK----- 215

  Fly   178 EIETEDEPSSDTVICVADINPYGSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPL 242
               ||.|...|                            |..:||.....:  |.:..:...||:
Worm   216 ---TEAEKLWD----------------------------NMSLTEKEVFQS--HTRRRRTTRLPI 247

  Fly   243 AAPPPPPPPPAAEQVP------ETPASPTDDGEEPPAVYLSPYIRSRYMQESTPGLPTRLAPRDP 301
            .............:||      :..|..:..|.:...|.:|..:.|   .|||....|.......
Worm   248 IQNFEETEEGCIVEVPIPLIDLDNDAVESVTGPQHENVTVSENVLS---TESTDQEVTETKRLHD 309

  Fly   302 RQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDDALTMEHDNTSRETVITTG 366
            ..|:..||.    ||...|..:....|.....||:........:...|..:.:.::   |.:|.
Worm   310 SSRDFNPPR----IQDTPSTVIRPEGDQKDPMSSTSSKRRNTNNSRCASLLSNPHS---TPVTR- 366

  Fly   367 DPLMQKIDISENPDKIYFIRREDGTVHRGQVLQSRTTENAAAPDEYYVHYVGLNRRLDGWVGRHR 431
              ||:.|..|||.|....:..:...:.:    :.||.....:|:        ..||.:..:....
Worm   367 --LMRGILDSENSDNDEMLSNDQSEIAK----RPRTPRPRYSPE--------AQRRTNSRLSALT 417

  Fly   432 ISDN-ADDLGGITVLPAPPLA-------PDQPSTSRE-MLAQQAAAAAAASSERQKRAANKDYYL 487
            |..| ::||......|:...|       ||...||:: ....|:||.:..........:.:|
Worm   418 IDTNRSNDLNVDGSAPSSSSAASCGLSTPDPDRTSQQRRKGNQSAARSRKIKTPSPPLSQED--- 479

  Fly   488 SYCENSRYDYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESI--------------- 537
               |....|..|           |.:|.:......:......|.|||:.|
Worm   480 ---EPMELDSDD-----------DPVNELDNLPIVIDDPSYVLTKEHKEIFEQVKKSVSDRNEFS 530

  Fly   538 -TKIKYI------------DKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAY 589
             .:|..|            :::.||.:.:.|||.||||.|:...:.|::||:|..|.|.......
Worm   531 PAQISEIYRSSKGEQARLPERIHFGAFIMKTWYGSPFPAEFINVKKLFICEFCFFYARSDEIMQN 595

  Fly   590 HLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYFDMDPFLFYILCE 654
            |..:|..|.|||.||||||:||::||:|:.:..|||.|||::::||:.|.:::|.:||.|||:..
Worm   596 HAKKCMLRAPPGLEIYRKGDISVFEVDGRLQKEYCQTLCLVSRMFLESKTVFYDTEPFFFYIVTI 660

  Fly   655 TDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSD 719
            .|..|.|..|||||||...:..|::||:.||.:|..|.|:.||..||.|||||...|.||:|||:
Worm   661 NDDIGCHFAGYFSKEKYEPDVNNLSCIMTLPCYQEMGLGRFLIDISYALSRKEKWFGGPEQPLSE 725

  Fly   720 LGRLSYRSYWAYTLLELMKTRCAPE-----QITIKELSEMSGITHDDIIYTLQSMKMIK------ 773
            |||.:|..||..|:...: .|...|     .|:||.:::.:|:...||:..:.|:...|
Worm   726 LGRKAYGGYWRTTIASCL-GRLKDELEFGSGISIKMIADDTGVNCHDILEVVCSLGWAKPVDPDE 789

  Fly   774 ---Y-------WKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSPQ 814
               |       |...::|...|:.         .|:.|:..|.:.|.|.|:
Worm   790 KNHYKLEWDVDWDMVSIILRESEA---------SKETKVQYDPECLDWVPR 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mof	NP_511051.1	Tudor-knot	382..432	CDD:288553	5/49 (10%)
		NAT_SF	528..813	CDD:302625	114/333 (34%)
		MOZ_SAS	599..778	CDD:280097	81/199 (41%)
lsy-12	NP_001263849.1	NAT_SF	550..783	CDD:302625	97/233 (42%)
lsy-12	NP_001263849.1	MOZ_SAS	605..786	CDD:280097	79/181 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920