DRSC/TRiP Functional Genomics Resources

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Protein Alignment mof and Kat6a

DIOPT Version :10

Sequence 1:NP_511051.1 Gene:mof / 31518 FlyBaseID:FBgn0014340 Length:827 Species:Drosophila melanogaster
Sequence 2:NP_001094040.1 Gene:Kat6a / 306571 RGDID:1304892 Length:1998 Species:Rattus norvegicus


Alignment Length:625 Identity:195/625 - (31%)
Similarity:302/625 - (48%) Gaps:120/625 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   272 PAVYLSPYIRSRYMQESTPGLPTRLAPRDPRQRNMPPPAV------------VLPIQTVLSANVE 324
            |.|.|.|:.:.:.:.|..|.....|..::..:...|...:            .|.....|:..|.
  Rat   189 PPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEDLISCADCGNSGHPSCLKFSPELTVRVR 253

  Fly   325 AISDDSSETSSSDDDEEEEEDEDDALTMEHDNTSRETVITTGDP--------------------- 368
            |:.....|..:.....::.::.|:.|..  |:..|...:...||                     
  Rat   254 ALRWQCIECKTCSSCRDQGKNADNMLFC--DSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKG 316

  Fly   369 --LMQKIDISENPDKIYFIRR--------------EDGTVHRGQVLQSRT-------------TE 404
              |:||        |...|:|              :..||.:|...:.||             ::
  Rat   317 RKLLQK--------KAAQIKRRYANPIGRPKNRLKKQSTVSKGPFSKVRTGPGRGRKRKITVSSQ 373

  Fly   405 NAAAPDEYYVHYV-GL------------NRRLDGWVGRHRISDNADDLGGITVLPAPPLAPDQPS 456
            :|::.:|.|:..: ||            |::..|.:            .|:|....|  :||   
  Rat   374 SASSSEEGYLERIDGLDFCRDSSAPLKFNKKTKGLI------------DGLTKFFTP--SPD--- 421

  Fly   457 TSREMLAQQAAAAAAASSE-RQKRAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDEINHVQKSH 520
                  .::|...|...|| |.::..|:....|:......|..:.|. ..::|.:.....:.:..
  Rat   422 ------GRKARGEAVDYSELRIRKKGNRKSSTSHWPTDNQDGWESKQ-ESEERLFGSQEIMTERD 479

  Fly   521 AEL--TATQAALEKEHESIT-----KIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCL 578
            .||  ...:.||:|  ..:|     :::....::||.|||.|||.||:|:||.:...||:||:||
  Rat   480 MELFRDIQEQALQK--VGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCL 542

  Fly   579 KYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYFD 643
            |||:.|:....|:.:|....||..|||||.|||::||:|...::|||.|||:||||||||.||:|
  Rat   543 KYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYD 607

  Fly   644 MDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKEG 708
            ::|||||:|.:.|.:|.|:||||||||...:.|||:||::||.:||||:|:.||.|||.||::||
  Rat   608 VEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREG 672

  Fly   709 VIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMIK 773
            ..|||||||||||||||.:||...:||.:..: ..:||:||:||:::|:...||..||..::|:.
  Rat   673 QAGSPEKPLSDLGRLSYMAYWKSVILECLYHQ-NDKQISIKKLSKLTGVCPQDITSTLHHLRMLD 736

  Fly   774 YWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSP 813
            :...|.||....|.||||:...|.....:.:|.:.|.|:|
  Rat   737 FRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTP 776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mofNP_511051.1 PLN00104 387..813 CDD:215056 170/473 (36%)
Kat6aNP_001094040.1 Required for activation of RUNX1-1. /evidence=ECO:0000250|UniProtKB:Q92794 1..144
Required for nuclear localization. /evidence=ECO:0000250 52..166
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..93
H15 85..162 CDD:197772
Interaction with PML. /evidence=ECO:0000250 144..662 143/508 (28%)
PHD1_MOZ_MORF 205..262 CDD:277090 7/56 (13%)
PHD2_KAT6A_6B 264..310 CDD:277002 6/47 (13%)
Interaction with RUNX1-1. /evidence=ECO:0000250 312..662 124/383 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 336..377 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..464 4/24 (17%)
Catalytic. /evidence=ECO:0000250 486..776 140/292 (48%)
PLN00104 <502..776 CDD:215056 136/274 (50%)
Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250 505..808 137/273 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 783..947
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 982..1079
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1096..1175
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1195..1436
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1450..1567
Interaction with PML. /evidence=ECO:0000250 1510..1735
Interaction with RUNX1-2. /evidence=ECO:0000250 1510..1635
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1630..1702
Required for activation of RUNX1-2. /evidence=ECO:0000250 1907..1942
Blue background indicates that the domain is not in the aligned region.

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