Protein Alignment mof and KAT6B

DIOPT Version :10

• Sequence 1: NP_511051.1
• Gene: mof / 31518
• FlyBaseID: FBgn0014340
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_036462.2
• Gene: KAT6B / 23522
• HGNCID: 17582
• Length: 2073
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 202/691 - (29%)
• Similarity: 309/691 - (44%)
• Gaps: 116/691 - (16%)

  Fly   181 TEDEPSSDTVICVADINPY-GSGSNIDDFVMDPDAPPNAIITEVVTIPAPLHLKGTQQLGLPLAA 244
            |.||.|         :|.: |.||           |.....|:|.|.|:..|....:.....||.
Human   357 TSDEGS---------MNAFTGRGS-----------PGRGQKTKVCTTPSSGHAASGKDSSSRLAV 401

  Fly   245 PPPPPPPPAAEQVPETPA------------------------SPTDDGEEP--PAVYLSPYIRSR 283
             ..|..|.|..::..|..                        :|:.||...  ..:..|.:.|.|
Human   402 -TDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKHYRPR 465

  Fly   284 YMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSETSSSDDDEEEEEDEDD 348
            ..........:.:......|:..|||: .||..|.:|....:....|:.|||........:....
Human   466 KKVSQKQSCTSHVLATGTTQKLKPPPS-SLPPPTPISGQSPSSQKSSTATSSPSPQSSSSQCSVP 529

  Fly   349 ALT--------------MEHDNTSRETVITTGDP-------LMQKIDISEN-PDKIYFIRREDGT 391
            :|:              :.|..|::......|.|       :.:|.::|.. ..|.:|..:.|
Human   530 SLSSLTTNSQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMRRKTELSSTAKSKAHFFGKRD-- 592

  Fly   392 VHRGQVLQSRTTENAAAPD---------EYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVLPA 447
                  ::||...::::..         :...|:     :...::.:||:      ||.:.....
Human   593 ------IRSRFISHSSSSSWGMARGSIFKAIAHF-----KRTTFLKKHRM------LGRLKYKVT 640

  Fly   448 PPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRYDYSDRKMTRYQKRRYDE 512
            |.:....|            ...:.:..|.|...:.|..:..  |.:.:.:|..:...:....:|
Human   641 PQMGTPSP------------GKGSLTDGRIKPDQDDDTEIKI--NIKQESADVNVIGNKDVVTEE 691

  Fly   513 INHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFSPFPEEYGKARTLYVCEYC 577
            ...|.|...||:..:...|...|...  :|...::||.|||.|||.||:|:||.:...||:||:|
Human   692 DLDVFKQAQELSWEKIECESGVEDCG--RYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFC 754

  Fly   578 LKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQLLCLMAKLFLDHKVLYF 642
            ||||:.::....|..:|....||..||||:.::|::||:|....:|||.|||:||||||||.||:
Human   755 LKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYY 819

  Fly   643 DMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRKGFGKLLIAFSYELSRKE 707
            |::|||||:|.:.|::|.|:||||||||...:.|||:||:::|.|||:|||:.||.|||.|||:|
Human   820 DVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRRE 884

  Fly   708 GVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMSGITHDDIIYTLQSMKMI 772
            |..|||||||||||||||.:||...:||.:... ....|:||.:|..:|:...||..|||.:.||
Human   885 GQAGSPEKPLSDLGRLSYLAYWKSVILEYLYHH-HERHISIKAISRATGMCPHDIATTLQHLHMI 948

  Fly   773 KYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYLVWSP 813
            ....|:.||....|.|..|::..:.......:|.|.|.|:|
Human   949 DKRDGRFVIIRREKLILSHMEKLKTCSRANELDPDSLRWTP 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mof	NP_511051.1	PLN00104	387..813	CDD:215056	154/434 (35%)
KAT6B	NP_036462.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..97
		H15	113..167	CDD:197772
		PHD1_MOZ_MORF	212..269	CDD:277090
		PHD2_KAT6A_6B	271..317	CDD:277002
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..409		16/69 (23%)
		Negatively regulates HAT activity	361..717		66/410 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..531		18/89 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..583		4/29 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..663		4/35 (11%)
		Catalytic	718..1008		133/273 (49%)
		PLN00104	<721..989	CDD:215056	131/268 (49%)
		Interaction with BRPF1. /evidence=ECO:0000269|PubMed:18794358	752..1008		116/239 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1022..1452
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1484..1538
		Interaction with RUNX1 and RUNX2. /evidence=ECO:0000269|PubMed:11965546	1560..2073
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1580..1619