DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mof and KAT7

DIOPT Version :9

Sequence 1:	NP_511051.1	Gene:	mof / 31518	FlyBaseID:	FBgn0014340	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_008998.1	Gene:	KAT7 / 11143	HGNCID:	17016	Length:	611	Species:	Homo sapiens

Alignment Length:	598	Identity:	195/598 - (32%)
Similarity:	288/598 - (48%)	Gaps:	108/598 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 GEEPPAVYLSPYIRSRYMQESTPGLPTRLAPRDPRQRNMPPPAVVLPIQTVLSANVEAISDDSSE 332
            |.|.||.......||:  |:.||..|.:...|..|........||            ..||..::
Human    66 GTEEPAYSTRRVTRSQ--QQPTPVTPKKYPLRQTRSSGSETEQVV------------DFSDRETK 116

  Fly   333 TSSSDDDEEEEEDEDDALTMEHD------NTSRETVITTGDPLMQK-IDISENPDKIYF------ 384
            .::..|:........:|.:.|.|      |.|.:..|.....|... .|:|..|.:..|
Human   117 NTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNF 181

  Fly   385 -----------IRREDGTVHRGQVLQSRTTENAAAPDEYYVHYVGLNRRLDGWVGRHRISDNADD 438
                       :....|...|...:......:..:.||..|.....:::::..:..||..||
Human   182 NMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDN--- 243

  Fly   439 LGGITVLPAPPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRYDYSDRKMT 503
                                     .:.|....|.:|||.|...|...|....||       .::
Human   244 -------------------------NRHATRHQAPTERQLRYKEKVAELRKKRNS-------GLS 276

  Fly   504 RYQKRRYDEINHVQ-------------KSHAELTATQAALEKEHESITKIK----------YIDK 545
            :.||.:|.|  |.|             .|..:|...:.|..:..|.:.|::          .|..
Human   277 KEQKEKYME--HRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKT 339

  Fly   546 LQFGNYEIDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNI 610
            :.||.||:||||.||:||||.:...||:||:|||||:.::....|:.:|..:.|||.||||||:|
Human   340 IAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSI 404

  Fly   611 SIYEVNGKEESLYCQLLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLEN 675
            |::||:||:..:|||.|||:||||||||.||:|::|||||::.|.|..|.|::|||||||.|..|
Human   405 SVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLN 469

  Fly   676 YNVACILVLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTR 740
            |||:|||.:|.:.|:|:||:||.|||.||:.|..:||||:||||||.:||||||...||..:. .
Human   470 YNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLH-N 533

  Fly   741 CAPEQITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPK---- 801
            ...::|:|||:|:.:.:...||:.|||:::|:|||||::::......|.:.:.    |:.|
Human   534 FQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIA----KEAKRSNS 594

  Fly   802 -LTIDTDYLVWSP 813
             .|:|...|.|:|
Human   595 NKTMDPSCLKWTP 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mof	NP_511051.1	Tudor-knot	382..432	CDD:288553	7/66 (11%)
		NAT_SF	528..813	CDD:302625	139/299 (46%)
		MOZ_SAS	599..778	CDD:280097	102/178 (57%)
KAT7	NP_008998.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..173		27/120 (23%)
		zf-C2HC	184..212	CDD:396216	2/27 (7%)
		PLN00104	<324..609	CDD:215056	137/289 (47%)
		acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:28334966, ECO:0000269\|PubMed:31827282, ECO:0007744\|PDB:5GK9, ECO:0007744\|PDB:6MAK	475..477		1/1 (100%)
		WM-3835 inhibitor binding. /evidence=ECO:0000269\|PubMed:31827282, ECO:0007744\|PDB:6MAJ	483..488		2/4 (50%)
		acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:28334966, ECO:0000269\|PubMed:31827282, ECO:0007744\|PDB:5GK9, ECO:0007744\|PDB:6MAK	483..488		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820