Protein Alignment GAA1 and GPAA1

DIOPT Version :9

• Sequence 1: NP_572273.2
• Gene: GAA1 / 31517
• FlyBaseID: FBgn0029818
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_003792.1
• Gene: GPAA1 / 8733
• HGNCID: 4446
• Length: 621
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 231/684 - (33%)
• Similarity: 325/684 - (47%)
• Gaps: 108/684 - (15%)

  Fly     1 MGLLSDPSISTQSKLVDGLARHVRK----VCYALYVAGVAWFFCLALPEFNHGTYLSENALSPGL 61
            ||||||| :..::     |||.|.:    :|...||||:|||..|..|.....||:||||:...:
Human     1 MGLLSDP-VRRRA-----LARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTM 59

  Fly    62 VYPEIRIDANRLAIQLLEELQRERKDHLSTTPHAWIAAKMNEFGLETHTHNYTLRYPFGGGKEYH 126
            |  |.:......|.....:....||.. ...|.||:...|...|||.:|.:::.:.||  ..|.|
Human    60 V--EEQFAGGDRARAFARDFAAHRKKS-GALPVAWLERTMRSVGLEVYTQSFSRKLPF--PDETH 119

  Fly   127 ------GKNIYGILRAPRIASTEGIVFAAPYRAASSVHTDISASVPLLLAFADFARRKNYWAKDL 185
                  |.|:||||||||.||||.:|...|..:.|:    .|.:|.||||.|...|.:.|||||:
Human   120 ERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDST----NSQAVGLLLALAAHFRGQIYWAKDI 180

  Fly   186 IFLITEQEQLGMQAWLEAYHDGDRELDLSKAYLRPGNLPARAGSLQAALNIEVQDLEIDHVDVRI 250
            :||:||.:.||.:|||||||      |::...::...|..|||::|||:.:|:....:..:||.:
Human   181 VFLVTEHDLLGTEAWLEAYH------DVNVTGMQSSPLQGRAGAIQAAVALELSSDVVTSLDVAV 239

  Fly   251 EGLNGKLPNLDMFNLVQRIMAREGIASGYKQAPRKKRRHSQSHFEQNFRQMLTMLASQSSGVPTG 315
            |||||:|||||:.||.|....:.|:....:...:.:...|.....|..:.:|.|:..|:||.|.|
Human   240 EGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASGRPHG 304

  Fly   316 NHGLFHRYRIDALTIAANRRATHATLKGSPGSAAVPLLKAIEGIARSLNNLLERFHQSFFFYVIV 380
            :||||.|||::|||:    |..::..:......||.  ||:||:.|.||:||||.|||||.|::.
Human   305 SHGLFLRYRVEALTL----RGINSFRQYKYDLVAVG--KALEGMFRKLNHLLERLHQSFFLYLLP 363

  Fly   381 SNDRYISIGDYMPALVALVACAFLKAYLTWSTLPATNAELEKAAGWLREHEQEAELEE------- 438
            ...|::|||.||||:..|:....|||           .||     |::.||....|||
Human   364 GLSRFVSIGLYMPAVGFLLLVLGLKA-----------LEL-----WMQLHEAGMGLEEPGGAPGP 412

  Fly   439 --NLEPDKFELPYGSVLIYLTATLLI----GFLCNVLPL------QQYFLEIPMGAAPLTTSVLS 491
              .|.|.:     |..|..|.|.|||    |....|||:      .|:|   |:..|......|.
Human   413 SVPLPPSQ-----GVGLASLVAPLLISQAMGLALYVLPVLGQHVATQHF---PVAEAEAVVLTLL 469

  Fly   492 FLSLIGFVLP-----FVVVLPP--GGLELLHVAFLLIY-----GCALIVIGLLNFALGLFAAVLT 544
            .:...|..||     .|....|  |.:.|..||  |||     ||    |.|.||:||...|...
Human   470 AIYAAGLALPHNTHRVVSTQAPDRGWMALKLVA--LIYLALQLGC----IALTNFSLGFLLATTM 528

  Fly   545 VPLVIALETKEENSRSTLRNTIRLATLVMNPMMVVYVIVLAMTFYQFPELPVQKIMLRAATAAMD 609
            ||  .|...|....|     |:..|.||:.......:..|.: :.:..|.|:.  :.......:.
Human   529 VP--TAALAKPHGPR-----TLYAALLVLTSPAATLLGSLFL-WRELQEAPLS--LAEGWQLFLA 583

  Fly   610 ASAYGLIDSVIYGNWLYFVICTIFLPLWIICWTL 643
            |.|.|:::...||..|:.::.....|.|::.|.:
Human   584 ALAQGVLEHHTYGALLFPLLSLGLYPCWLLFWNV 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAA1	NP_572273.2	Gaa1	127..639	CDD:282032	186/542 (34%)
GPAA1	NP_003792.1	Gaa1	126..613	CDD:309298	186/542 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146173
Domainoid	1	1.000	220	1.000	Domainoid score	I2633
eggNOG	1	0.900	-	-		E1_KOG3566
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37852
Inparanoid	1	1.050	270	1.000	Inparanoid score	I3015
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46078
OrthoDB	1	1.010	-	-		D1486030at2759
OrthoFinder	1	1.000	-	-		FOG0005054
OrthoInspector	1	1.000	-	-		oto90626
orthoMCL	1	0.900	-	-		OOG6_104164
Panther	1	1.100	-	-	LDO	PTHR13304
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R467
SonicParanoid	1	1.000	-	-		X3579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800