DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15767 and PPID

DIOPT Version :9

Sequence 1:	NP_572264.1	Gene:	CG15767 / 31508	FlyBaseID:	FBgn0029809	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_005029.1	Gene:	PPID / 5481	HGNCID:	9257	Length:	370	Species:	Homo sapiens

Alignment Length:	178	Identity:	42/178 - (23%)
Similarity:	69/178 - (38%)	Gaps:	26/178 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 PRIVLHFGLMDGRPLGQVVVQLYTEAAPLVVLQFVRTCLGQR--SHEFA---------VRRIFPR 257
            ||:.....: .|..:|::|::|:.:..|.....|...|.|::  .|...         ..||..:
Human    16 PRVFFDVDI-GGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIKK 79

  Fly   258 LWVEGYLLSSCKNSLGEASSLSYRDPMEFDTRVVSHARYAFVLSCAKEYCVHGFPGGAINFSISF 322
            ..::|   ....|..|......|.:..|.:.....|.|.. :||.|..    |.......|.|:.
Human    80 FMIQG---GDFSNQNGTGGESIYGEKFEDENFHYKHDREG-LLSMANA----GRNTNGSQFFITT 136

  Fly   323 KPLPVARGQRVGFGRVIRG---DKVIEAMEAHGTKNGKISRPLLITHC 367
            .|.|...|:.|.||:||:|   .:::|.:|..|.|..|:   .:|..|
Human   137 VPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKL---CVIAEC 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15767	NP_572264.1	cyclophilin	203..370	CDD:294131	42/178 (24%)
PPID	NP_005029.1	cyclophilin_ABH_like	16..182	CDD:238907	42/178 (24%)
		Chaperone activity. /evidence=ECO:0000250	185..215
		PLN03088	192..>362	CDD:330826
		Interaction with HSP90AB1. /evidence=ECO:0000250	214..370
		TPR repeat	224..267	CDD:276809
		TPR repeat	272..302	CDD:276809
		TPR repeat	307..333	CDD:276809
		TPR repeat	341..364	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810