DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15767 and CWC27

DIOPT Version :9

Sequence 1:	NP_572264.1	Gene:	CG15767 / 31508	FlyBaseID:	FBgn0029809	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_005860.2	Gene:	CWC27 / 10283	HGNCID:	10664	Length:	472	Species:	Homo sapiens

Alignment Length:	160	Identity:	37/160 - (23%)
Similarity:	58/160 - (36%)	Gaps:	22/160 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 GQVVVQLYTEAAPLVVLQFVRTCLGQRSHEFAVRRIFPRLWVEGYLLSSCKNSLGEASSLSYRDP 283
            |.:.::|:::.||.....|::.||..........|:.|...|:|    ......|......|..|
Human    22 GDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQG----GDPTGTGSGGESIYGAP 82

  Fly   284 M--EFDTRVVSHARYAFVLSCAKEYCVHGFPGGAINFSISFKPLPVA---RGQRVGFGRVIRGDK 343
            .  ||.:|:..:.|....::.|         |...|.|..|..|..|   ..:...||:| .||.
Human    83 FKDEFHSRLRFNRRGLVAMANA---------GSHDNGSQFFFTLGRADELNNKHTIFGKV-TGDT 137

  Fly   344 V---IEAMEAHGTKNGKISRPLLITHCELL 370
            |   :...|.....:.:...|..|..||:|
Human   138 VYNMLRLSEVDIDDDERPHNPHKIKSCEVL 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15767	NP_572264.1	cyclophilin	203..370	CDD:294131	36/158 (23%)
CWC27	NP_005860.2	cyclophilin_CeCYP16-like	8..178	CDD:238906	37/160 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..386
		DUF5401	<302..>472	CDD:375164
		CWC27_CTD	376..428	CDD:412084
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0652
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900