DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42699 and Cep162

DIOPT Version :9

Sequence 1:	NP_572263.2	Gene:	CG42699 / 31507	FlyBaseID:	FBgn0261610	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_955020.2	Gene:	Cep162 / 382090	MGIID:	1925343	Length:	1403	Species:	Mus musculus

Alignment Length:	1040	Identity:	190/1040 - (18%)
Similarity:	369/1040 - (35%)	Gaps:	349/1040 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ESIFQEVSRLSDSTDMRSVDELLQEAERLIQ---QQLRLGGIVPKLDASGP-------PA----- 95
            :.::.|:.:...|.:    ..||.:.:::.|   .||..|..||.:....|       |:
Mouse   439 DKMYLEILKKKTSVN----PSLLPQDDKMNQTSRSQLGAGEEVPVIGKQVPCKKARSTPSLPKRK 499

  Fly    96 PTKTLGEEAATGGDGSSSSP----QSSPHSSIRLNTRYTHRIEHSP-APLAPKTVAVNGR--VRP 153
            |...|...|.:.|.|..|||    .:....:.:.||: |..:...| :....|...::|.  ::|
Mouse   500 PQSGLYASARSSGYGKPSSPLQLFSALEKKTSKDNTK-TKSVRSIPTSNQFRKREILSGTKLIKP 563

  Fly   154 RSGSKSS----ASPTSVQTPLESSNGCGFAAFV----------------------------DNLP 186
            .:.:|.|    .||.:.:.|.:.|:.    :||                            :...
Mouse   564 AASNKPSPHREGSPATPKRPEDPSDD----SFVQLQTEPLGSYGGNREKELLMLKRAQDAEEKWT 624

  Fly   187 SASVISEES----TPKDMDMENHTAAMAKLQLQQL----QDN----------------------- 220
            .|..:.|:.    ..|:.::||...::.:.|.::|    |:|
Mouse   625 GAQALMEQMKMTFCEKEKELENTVESLKRQQERELFRLNQENYILQAKLSSFEETSRKQRWLQFG 689

  Fly   221 -TDDD------EDTMEEITEAEV--------DAPIFSRAEDTGKEVRSPPERQFKSQGRSYIQPS 270
             |.|.      :...:||.|.|.        :..::::.:|..::.:...||.||.....:.:
Mouse   690 ETSDPLTGEKLKQIQKEIQEQETLLQGYQQENERLYNQVKDLQEQNKKNEERMFKENQNLFSE-- 752

  Fly   271 QPIRPMASYSE---------KAVGSSPKRMVSTLTSPIEQI-ASSVSREH-------------AL 312
                 :||..|         :||.::......:.|..:.:: |:...:.|             ||
Mouse   753 -----LASLKEQMHKNHFLSQAVENTEPTKNQSFTDLLAELRAAQKEKNHLMEDIKRLKQDKQAL 812

  Fly   313 KLEIEQL---QERLKD-----TEERLASVRLQSDSLSQTQRALREHNSRLQEESEMLKLDVQHL- 368
            ::::|::   :::.||     |.|:|..:::..::..|....|::......|..|:|..|...|
Mouse   813 EVDLEKVKRERDQAKDQIAYATGEKLYEIKILEETHKQEVSRLQKRLQWYAENQELLDRDAARLR 877

  Fly   369 --NECANVLRSELQAARRDRGEALQMQRSLRDELEEANQERRRTGEGKEKDSRVIQDLQRQCREM 431
              ||....||.|::..:.:.|             ..|.|:|.|:.| :..|::.||||:||.:||
Mouse   878 EANEETEKLRLEIEKLKTESG-------------SPATQQRLRSKE-RALDAKRIQDLERQVKEM 928

  Fly   432 ERILMRKHPDSVSALIVASKSSGMCPLNDQENVNSRKLLEQRIAQLESDAKEQDRKAQQILANVQ 496
            |.||.|::|:|:.|||:|:.::|     |..:.|:.:.:|:||.:||:|.:.:|.:|::.|..::
Mouse   929 EGILKRRYPNSLPALILAASAAG-----DSVDRNTVEFMERRIKKLEADLEGKDEEAKKSLRTME 988

  Fly   497 ARFNSVQAKYETHIADLETQVLSLQEINTKLNEQIESQVRTLDRYMQKRADRYYNNCTQTEPLEE 561
            .:|..::.:||                     :::|.|.:.| .:.||.|.:...|.
Mouse   989 QQFQKMKIQYE---------------------QRLEEQEQLL-AHRQKEAPQSQRNS-------- 1023

  Fly   562 DDVSVGGGVNHGRATPVSSNTMGTQTQAANGTRDHSTNTIGCPSPALVCQQQHLHQAHGHLHPHA 626
                             ||.....:|:..:....|........:...|.:.|:....|
Mouse  1024 -----------------SSRLKALETELGDIKEAHQITVRKLEAEIDVLKHQNADLEH------- 1064

  Fly   627 PSASSSTSSTANSTPNTSRPNSKQSGGQRRSPLVTAGPSKLPISQSDSTLSLLSHGGGGSKEEAQ 691
                              :.|.|                      .|..|..:..    ..|:||
Mouse  1065 ------------------KKNDK----------------------GDQGLQSIEF----QVEQAQ 1085

  Fly   692 LLSSVRSMRVDLAIKNKAMQRLTRELDECKKTIRKLQRDKEGSGSGSQTGSKLDLR--SQASGGA 754
            ..:.:..:..:||.|.:.:|.||:.::..:|. |::...::...|..:|.:|...:  ::..|.|
Mouse  1086 ARAKLARLNEELAAKGREIQDLTKTVERLQKE-RRMMLSRQIPRSREETAAKRLKKDPNRGHGNA 1149

  Fly   755 MQQRRSSGYDHHHHSDHIPAATESQALKEAQNKYRL------------------------LEADY 795
            ..:.......|.|      ..|:|...:..:..|||                        ||...
Mouse  1150 FPETLDGKLYHPH------TFTDSHISEVLEENYRLRSELEGLILERSKLKMESEAAVCQLENSM 1208

  Fly   796 KTLHDKRLQDLKTLQSAHEREL----------------ASCNETV-------------------- 824
            |.:.|.....:.:|:::||||:                |..|..:
Mouse  1209 KRVKDDAAAHIASLKASHEREIEKLLCQNAIENSSSKVAELNRKIATQEVLLKHFQGQVNELQGK 1273

  Fly   825 -----------RILQQRLNEREEALTTQKRRKVP--VDYYALKAKVSLLERRHSEREERLHMLVE 876
                       .|||:::.:..|.|...|....|  ..:..|:.|:..:|.||.:||:.|..:::
Mouse  1274 QESLAVSQVREEILQKQITKLLEELKEAKENHTPEMKHFMGLERKIKQMEMRHRQREQELQQIIQ 1338

Fly 877 876
Mouse 1339 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42699	NP_572263.2	FlaC	<316..423	CDD:225888	26/117 (22%)
Cep162	NP_955020.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..46
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..243
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..292
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..348
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	453..606		33/161 (20%)
		Smc	<617..1301	CDD:224117	145/814 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1147		3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28K8R
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto95106
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR34031
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5843
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.030