DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3108 and AIP5

DIOPT Version :9

Sequence 1:	NP_572262.1	Gene:	CG3108 / 31506	FlyBaseID:	FBgn0029807	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_116671.1	Gene:	AIP5 / 850570	SGDID:	S000001912	Length:	1233	Species:	Saccharomyces cerevisiae

Alignment Length:	1019	Identity:	219/1019 - (21%)
Similarity:	376/1019 - (36%)	Gaps:	276/1019 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ERNELPADQQQQQQQD-------VLVDNMKLTSIPSADSSDMYMLVPDTVASQLEDTEHVNRNSI 103
            |...|.|.::||.:.|       ||..|.|.|.|...|.          |..|.:..:...|..:
Yeast   352 ESKHLKAGEKQQTESDRDGISPSVLAKNQKETEIGKEDH----------VFEQKDKEDEKCRKEL 406

  Fly   104 EADPESDPS---GSSSSDMLMLESDSSPAMQLVELPSDITVAESQPETEHDTENDQQQPESIEEH 165
            ..:.|::.|   .::.||.::                       .||||.:|.:|:
Yeast   407 SVNHENNMSHNFNAAGSDSII-----------------------PPETERETYDDE--------- 439

  Fly   166 VVLMKPASQEAQLEQTVDLATEAAPVPL-NDELPEDEESPAATESAV--EELEKESEAAMDDQV- 226
              .|.|..:.:..|:.:...|....|.: .:|..|:||...:|.|.|  |.:..|.||..:::|
Yeast   440 --TMGPTKRISDNEKNLQHGTNDISVEVEKEEEEEEEEEENSTFSKVKKENVTGEQEAVRNNEVS 502

  Fly   227 --PEESEIQPEQVQPGEYQSESDGEQAE-------------TKPEIEAQPEVEAQPEAEAQPEAE 276
              .|||..:.|::..|:.:....||::.             :|..:..:.|.||..:.....|..
Yeast   503 GTEEESTSKGEEIMGGDEKQSEAGEKSSIIEIEGSANSAKISKDNLVLEDEAEAPTQENKPTEVV 567

  Fly   277 PQLEV--EPQPEVESQPEVESQ--PE-VEAQPEVEPQSEVE-SQP------------EAESHSE- 322
            .::::  .|:.:||....||..  || :|...|.:...:|: .:|            .|||.||
Yeast   568 GEIDIPDAPRDDVEIVEAVEKNIIPEDLEVAKEDQEGEQVKLDEPVKAMKDDKIAMRGAESISED 632

  Fly   323 ----PETQAEV---EAQPEV-ESLPEAESQPEAE-SQPEREPEV-------EAEKISDNEVDTTE 371
                .|..||:   :|:.|| |:..|:....|.| |:....|:|       ..|.:..||.|.
Yeast   633 MKKKQEGTAELSNEKAKKEVDETARESAEGVEVEKSKTPESPKVVKRCTSGRPEDLQINERDP-- 695

  Fly   372 ASLMETLVEGIEDGLTAAMDNLVPEELAEASDKQETELESEDQQSPVTEAIE---EQAVPEIEQ- 432
                |.|.|.:.          ||:|  :...:..|.:|:.:::.|.::.::   |||  |..|
Yeast   696 ----EVLKEDVR----------VPDE--DVKPEIATTIENSEEEDPKSQRVQISTEQA--ETTQK 742

  Fly   433 -----------EKEKEPEQITLADETEQDSAQPSNEEPVEIAPEQHTEAEIAPAKIPEEGKPEEE 486
                       ::|::|::..:..|.::.:.:.:|.|..|.     |||....:|..:.|..|:.
Yeast   743 DMGDVGSTTSFKEEEKPKRFEITQEGDKITGKDTNHEHGEA-----TEAASENSKASDVGTAEKY 802

  Fly   487 VQVEEESKPVEESKPEEEIKQ--QEDAKPEEDDQNYAETQPAVTEVKPEETPADIPVEIPAEVPA 549
            ::...||           :|:  :|||:.|..::.      ...:||.|....|.|.|  |||.|
Yeast   803 IEPSSES-----------VKKDTEEDAEVENSEKT------EFIKVKAELENLDAPKE--AEVTA 848

  Fly   550 EI-----PAEIPAEVPAEIPAESPAEIAAEVPAEIPAEIPAEIPAETPAETHAEIPADVPAQVVA 609
            |:     ..|:..|..||:......|. .:|.||: ..:.|...||..||.:.| ..||.....:
Yeast   849 ELNKENEDVEVDTEEDAEVENSEKTEF-IKVKAEL-GNLDAPKEAEVTAELNKE-NEDVEVAATS 910

  Fly   610 EAPAETPAETPAEVPAEIPSKVQDEIQSDSTQAEPQV-EKEAQQPEKETKPLESSLLTTIIPMVM 673
            :...||....|||.|.|           |.|..|.:| :|:|:...||.:.:|:|.:...:..|
Yeast   911 KEDIETKCSEPAETPIE-----------DGTCTEAEVSKKDAEAVTKEDENMENSKIAEALKDV- 963

  Fly   674 PQPQVPSQPLQVQDSVLNYVNASFMQQQPSETDLPKTEEESPFNAHLRRYDGAQVWRIVVQTDKD 738
                       ..|..::.:|.|...|:..|  ||:.|::.     ::...|......|.:|:|:
Yeast   964 -----------TGDQEIDDINISDEFQRTVE--LPELEKQD-----IKDNKGEDKELEVEETEKE 1010

  Fly   739 KRMADELQSKYDGQLWKEVKQE------VDYLLKPQVLAAA--------ERHIRAANLSRIVLID 789
            ..:.|.:..:...:...|:|||      :|:.....:...|        |......|..:....|
Yeast  1011 TSLPDLVVEENITEEKNEIKQEEEEVSQLDFNETESISKEAPNNDENGFEDQSTRENPKKASADD 1075

  Fly   790 NLQRVIEKENPPAEKI---------AELQNRKGHRLTWQAYHRLEDIHGFIDYMAKTYPDICSTE 845
            ..:.::::.|...|::         |.||:......|.|...:.:..:       ....|:.:|.
Yeast  1076 IFKDILDETNEFLEQLKIVDDSELNALLQSLDAKDSTTQTTEQSKKNN-------DKPQDVITTS 1133

  Fly   846 IIGYSVEKRPLKILKISNGNARNPGIWIDGGMHAREWISPATVTYIANQLVEGWEDLPEHMRSIN 910
            .|....||.|:.|.....|          ||.|.....:..:....||::...:.||
Yeast  1134 EIRKLNEKEPVYIYTSLAG----------GGFHMIPRTNRLSTILTANRIPFTYRDL-------- 1180

  Fly   911 WYIHPVANPDGYEYSHTTD---RLWRKNMRAHGRQCPGVDLNRN 951
                           .|.|   ::|:...:  ||..|||....|
Yeast  1181 ---------------GTDDEARKVWKTFSK--GRSLPGVVRGHN 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3108	NP_572262.1	Propep_M14	730..797	CDD:280416	13/80 (16%)
CG3108	NP_572262.1	M14_CP_A-B_like	821..1112	CDD:199844	24/134 (18%)
AIP5	NP_116671.1	2A1904	<271..>528	CDD:273344	49/219 (22%)
AIP5	NP_116671.1	PTZ00121	<482..1082	CDD:173412	152/676 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1	Normalized mean entropy	S7639
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950