DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3108 and Agtpbp1

DIOPT Version :9

Sequence 1:	NP_572262.1	Gene:	CG3108 / 31506	FlyBaseID:	FBgn0029807	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_001364026.1	Gene:	Agtpbp1 / 67269	MGIID:	2159437	Length:	1218	Species:	Mus musculus

Alignment Length:	906	Identity:	162/906 - (17%)
Similarity:	280/906 - (30%)	Gaps:	329/906 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 GLTAAMDNLVPE---ELAEASDKQETELESEDQQSPVTEAIEEQAVPEIEQEKEKEPEQITLADE 446
            |..|.:.:|.||   .:.|:.|..:.:||.|:                 |.|.|.:.:|....|:
Mouse   351 GPVAQLYSLPPEVDDVVDESDDNDDIDLEVEN-----------------ELENEDDLDQSFKNDD 398

  Fly   447 TEQDSAQPSNEEPVEIAPEQHTEAEIAPAKIPEEGKPEEEVQVEEESKPVEESKPEEEIKQQEDA 511
            .|.|.                  .::.|.::|                    .:..||:|..|..
Mouse   399 IETDI------------------NKLRPQQVP--------------------GRTIEELKMYEHL 425

  Fly   512 KPE--EDDQNY----AETQPAVTEVKPEETPADIPVEIPA---EVPAEIPAEIPAEVPAEIPAES 567
            .||  :|.|:|    .|.:|.|.|.|     |..|:.:|.   |||.. ...:...|..:..|..
Mouse   426 FPELVDDFQDYELISKEPKPFVFEGK-----ARGPIVVPTAGEEVPGN-SGSVKKGVVMKERASP 484

  Fly   568 PAEIAAEVPAEIPAEIPAEIPAETPAETHAEIPADVPAQVVAEAPAETPAETPAEVPAEIPSKVQ 632
            ..|.|.|.|......:|.::..::.....|....:...:.:...       |...||:::.|.:.
Mouse   485 KGEEAKEDPKGHDRTLPQQLGGQSRVAPSAHSFNNDLVKALDRI-------TLQNVPSQVASGLN 542

  Fly   633 DEIQSD---------STQAEPQVEK-----------------------------EAQQPEKETKP 659
            ..::.|         .|:|.|.|.|                             |:....::...
Mouse   543 AGMRKDFGLPLTVLSCTKACPHVAKCGSTLFEGRTVHLGKLCCTGVETEDDEDTESHSSTEQAPS 607

  Fly   660 LESSLLTTI------IPMVMPQPQVPSQPLQVQDSVLNYVNASFMQQQPSETDLPKTEEESPFNA 718
            :|:|...|:      |.:|.....||............::...|  ::|.        .|.|:.
Mouse   608 VEASDGPTLHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPF--KEPI--------LERPYG- 661

  Fly   719 HLRRYDGAQ-VWRIVVQTDKDKRMADEL----------------QSKYD-GQLWKEV---KQEVD 762
             ::|...|| :.|::.|.|...|:..:|                .||:: |.|.|.:   |.|.|
Mouse   662 -VQRTKIAQDIERLIHQNDIIDRVVYDLDNPTYTTPEEGDTLKFNSKFESGNLRKVIQIRKSEYD 725

  Fly   763 YLLKPQVLAAAERH-----------IRAANLSRIVLIDNLQRVIEKEN--------PPAEKIAEL 808
            .:|...:   ...|           :|.....|..:|:     .||.|        |....:.|.
Mouse   726 LILNSDI---NSNHYHQWFYFEVSGMRPGVAYRFNIIN-----CEKSNSQFNYGMQPLMYSVQEA 782

  Fly   809 QN------RKGHRLTW-----------------QAYHRLEDIHGF-----IDYMAKTYPDICSTE 845
            .|      |.|..:.:                 ::|:.:.....|     :.|.|..||...||
Mouse   783 LNARPWWIRMGTDICYYKNHFSRSSVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYST- 846

  Fly   846 IIGYSVEK-----RPLKI-------LKISNGN----------------------ARNPGIWIDGG 876
             :...::|     .|.:|       .:..:||                      ...|.|::...
Mouse   847 -LQMHLQKLESAHNPQQIYFRKDVLCETLSGNICPLVTITAMPESNYYEHICQFRTRPYIFLSAR 910

  Fly   877 MHARE----WISPATVTYIANQLVEGWEDLPEHMR-SINWYIHPVANPDGYEYSHTTDRLWRKNM 936
            :|..|    |:...|:.|:.:.     ....:.:| |..:.|.|:.||||....:
Mouse   911 VHPGETNASWVMKGTLEYLMSN-----SPTAQSLRESYIFKIVPMLNPDGVINGN---------- 960

  Fly   937 RAHGRQCPGVDLNRNFGYKWGGKGTSASPCSQTYRGSKAFSEPETFYISK----FISGFPRETFQ 997
              |.....|.||||    :|........|               |.|.:|    :::...|...
Mouse   961 --HRCSLSGEDLNR----QWQSPNPELHP---------------TIYHAKGLLQYLAAVKRLPL- 1003

  Fly   998 AYLSFHSYG-QYILYPWGYDYQLT-----QDRADLDRVARQAGTSITK--------------STG 1042
            .|..:|.:. :..::.:|...:.|     .:.|..|.|......::.|              |..
Mouse  1004 VYCDYHGHSRKKNVFMYGCSIKETVWHTHDNSASCDIVEDMGYRTLPKILSHIAPAFCMSSCSFV 1068

  Fly  1043 VKYTVGSSATTLYPAAGGSDDWAKGIAGIKYAYTIEMG----DTGRY-GFVLPARFIQYNG 1098
            |:.:..|:|..:.        |.:  .|::.:||:|..    |.||| |..:..|.::..|
Mouse  1069 VEKSKESTARVVV--------WRE--IGVQRSYTMESTLCGCDQGRYKGLQIGTRELEEMG 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3108	NP_572262.1	Propep_M14	730..797	CDD:280416	18/97 (19%)
CG3108	NP_572262.1	M14_CP_A-B_like	821..1112	CDD:199844	64/351 (18%)
Agtpbp1	NP_001364026.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..512		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..617		4/26 (15%)
		Pepdidase_M14_N	704..838	CDD:407865	24/141 (17%)
		M14_Nna1	861..1131	CDD:349477	54/306 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1193..1218
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900