DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3108 and NEFH

DIOPT Version :9

Sequence 1:	NP_572262.1	Gene:	CG3108 / 31506	FlyBaseID:	FBgn0029807	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_066554.2	Gene:	NEFH / 4744	HGNCID:	7737	Length:	1020	Species:	Homo sapiens

Alignment Length:	749	Identity:	192/749 - (25%)
Similarity:	317/749 - (42%)	Gaps:	154/749 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LNQVASMSLDRLALERNELPADQQQQQQQDVLVDNMKLTSIPSADSSDMYMLVPDTVASQLEDTE 96
            |::.|.::.|.:...:.|:...::|.|.:...::.:|.|.    ||.:..       .|:|||..
Human   300 LSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTK----DSLERQ-------RSELEDRH 353

  Fly    97 HVNRNSIEADPESDPSGSSSSDMLMLESDSSPAMQL--------VELPSDITVAE---------- 143
                   :||..|........|..:..:....|.||        |::..||.:|.
Human   354 -------QADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEEC 411

  Fly   144 ---------SQPE--------TEH---DTENDQQQPESIEEHVVLMKPASQEAQLEQTVDLATEA 188
                     |.||        :.|   .:|...:..|..|:..|:::..::|.|:.:.|   ||.
Human   412 RIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEV---TEE 473

  Fly   189 APVPLNDELPEDEESPAATESAVEELEKESEAAMDDQVPE---ESEIQPEQVQPGEYQSESDGEQ 250
            ......:|..::||.....|:...|.|.:|..|.:...||   :|.::.|...|.|.:| .:.|:
Human   474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS-PEKEE 537

  Fly   251 AETKPEIEAQPEVEAQP---EAEAQPEAE-PQLEVEPQP-EVESQPEVESQPEVEAQPEVEPQS- 309
            |::..|::: ||....|   ||::.|||: |:.|....| ||:|..:.:|..:.||:...|.:|
Human   538 AKSPAEVKS-PEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP 601

  Fly   310 ---------EVESQPEAES--HSEPETQAEVEAQPEVESLP---EAESQPEAESQPERE----PE 356
                     |.:|..||:|  ..|.::.|||:: ||....|   ||:| ||....||:|    ||
Human   602 EKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKS-PEKAKSPTKEEAKS-PEKAKSPEKEEAKSPE 664

  Fly   357 -----VEAEKISDNEVDTTEASLMETLVEGIEDGLTAAMDNLVPEELAEASDKQETELESEDQQS 416
                 |:||..|..:.    .|.::...:..|...:...:.....|.|::..|:|.: ..|..:|
Human   665 KAKSPVKAEAKSPEKA----KSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK-SPEKAKS 724

  Fly   417 PVTEAIE--EQAVPEIEQ-----EKEKEPEQITLADETEQDSAQPSNEE---PVEIAPEQHTEAE 471
            ||.|..:  |:|...:::     ||.|.||:....|....::..|:.||   |.:..||:.....
Human   725 PVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPV 789

  Fly   472 IAPAKIPEEGK---------PEEEVQVEEESK-PVEESKPEEEIKQQEDAKPEEDDQNYAETQPA 526
            ....|.||:.|         ||:|:..:||.| ||:|.:..:|:|.:|..|..|:::  |...|.
Human   790 KEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK--APATPK 852

  Fly   527 VTE---VKPEETP---ADIP---------VEIPAEVPAEIPAEIPAEVPAEIPA---ESPAEIAA 573
            ..|   .|.||.|   |..|         ||.|.|...|...| .||...::|.   |:||::
Human   853 TEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE-EAEDKKKVPTPEKEAPAKV-- 914

  Fly   574 EVPAEIPAEIPAEIPAETPAETHAEIPADVPAQVVAEAP-----AETPAETPAEVP-AEIPSKVQ 632
            ||..:...:...|:..:.|.:..|:.|:. ||:....||     .|..|:.|.|.| .|..:|..
Human   915 EVKEDAKPKEKTEVAKKEPDDAKAKEPSK-PAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978

  Fly   633 DEIQS---DSTQAEPQVEKEAQQPEKETKPLESS 663
            |:..|   ...:|| :.||.:...:|::||.|.:
Human   979 DKTLSKEPSKPKAE-KAEKSSSTDQKDSKPPEKA 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3108	NP_572262.1	Propep_M14	730..797	CDD:280416
CG3108	NP_572262.1	M14_CP_A-B_like	821..1112	CDD:199844
NEFH	NP_066554.2	Head	1..100
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..83
		Filament	96..412	CDD:278467	25/129 (19%)
		Coil 1A	101..132
		Linker 1	133..145
		Coil 1B	146..244
		Linker 12	245..266
		Coil 2A	267..288
		Linker 2	289..292
		Coil 2B	293..413		25/130 (19%)
		BASP1	513..736	CDD:283191	66/231 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910