DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3108 and CG13185

DIOPT Version :9

Sequence 1:	NP_572262.1	Gene:	CG3108 / 31506	FlyBaseID:	FBgn0029807	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_001097279.2	Gene:	CG13185 / 36268	FlyBaseID:	FBgn0033661	Length:	5526	Species:	Drosophila melanogaster

Alignment Length:	1064	Identity:	223/1064 - (20%)
Similarity:	390/1064 - (36%)	Gaps:	252/1064 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PKRIVTIGSLLLVLGLNQVASMSLDRLALERNE---LPADQQQQQQQDVLVDNMKLTSIPSADSS 78
            |:.:..:.::||||..:.....  |:|...|..   ||..:|.|...|.|:.....|...||...
  Fly  4513 PRVLGKLSNVLLVLKHSHFEGK--DKLLCVRRAIGLLPVLEQYQLLADYLLLQQLATHKVSAKML 4575

  Fly    79 DMYMLV------------PDTVASQLEDTEHVNRNSIEADPESDPSGSSSSDMLMLESDSSPAMQ 131
            .:.:.|            ||.:..:...::..::|. |.....|.:|         |:|:|..::
  Fly  4576 SIVLTVFVEIGSKGFCVPPDLMQDEEGQSKQESKNG-EGFGLEDGTG---------ENDASDKIE 4630

  Fly   132 LVELPSDITVAESQPETEHDTENDQQQPESIEEHVVLM------------KPASQEA-QLEQTVD 183
            ..:...|    ..:||...| |.|:|:|:..||..:.|            ||...:: :.|:..|
  Fly  4631 SEDQLDD----AKRPEDRKD-EGDKQEPDCKEEKGIEMSDDFDAKMQDVEKPEEDDSGESEEEED 4690

  Fly   184 L-----ATEAAPVPLNDEL--------PEDEESPAATE-----------SAVEELEKESEAAMDD 224
            |     .||.....|:|::        ||:|:.|...|           .|..:|:.:::||.:|
  Fly  4691 LNKEMGETEEGAEKLDDQIWGDDEEEKPEEEQEPDMNEEDQGKGSKDEKDAHNDLDTKNDAAKED 4755

  Fly   225 -------------QVPEESEIQPEQVQPGEYQSESDGEQAETKP---EIEAQPEV---------- 263
                         ..|...:.:.||.:..:...:.:.::.:|..   |:|..||.
  Fly  4756 GKDEHEKDGLDATNEPSGEDKRKEQAKDIDDMKDPEMDEEQTNAMHNELEEPPEPEEMDLGDMNN 4820

  Fly   264 --EAQPEAEAQPEAEPQLEVEPQPE---VESQPEVESQPEVEAQPEVEPQSE----------VES 313
              |...:.:.||..|...:::...|   ...:||.:...|.:|..|.:|||:          .|:
  Fly  4821 VDEGHDDQDEQPTDENPFDIDAMKENMQPAEEPEADGDDEHDANEEGDPQSDGSDSEEDEAGTEA 4885

  Fly   314 QPEAESHSEPETQAEVEAQPEVESLPEAESQPEAESQPEREPEVEAEKISDNEVDTTEASLMETL 378
            :|..|.|.|.|.....:.:.|.|:....|.:.|.:|:||..||...|:..:...:.
  Fly  4886 KPAEEDHGEGEEATPEDEKDEAETQKRGELEDEDDSKPEDSPEDSKEEKEEKREEK--------- 4941

  Fly   379 VEGIEDGLTAAMDNLVPEELAEASDK--QETELES--EDQQSPVTEAIEEQAVPEI-------EQ 432
                            |||.:::.||  :|..::|  |..||...:.:::...|:|       ||
  Fly  4942 ----------------PEEHSQSKDKASKEENVQSMPETDQSSSADQVQQPQDPDIKQDQKLDEQ 4990

  Fly   433 EKEKEPEQITLADETEQDSAQPSNEEPVEIAPEQHTEAEIAPAKIPEEGKPEEEVQVEE------ 491
            |..:|.:.:..|:....|.......|..|...::..:.|....:..::|:..||..:.|
  Fly  4991 ETGEEKDGVGQAENDADDGGHQGVAETQETVSQEDRKNERQTQEKRKQGRTNEERSLGEAEQNKL 5055

  Fly   492 -ESKPVEESKPEEEIKQQEDAKPEEDDQNYAETQPAVTEVK-PEETPADIPVEIPAEVPAEIPAE 554
             :.|.:::.|..:|....|..|||..||..||....|.|.| .::|..|...|..::.......|
  Fly  5056 KQLKTIDQLKDSKESDDAEQEKPEPMDQTEAEEYQHVKEPKNSDKTTLDNATEEQSKKIQHQEDE 5120

  Fly   555 IPAEVPAEIPAESPAEI-AAEVPAEIP---AEI------PAEIPAETPAETH-----------AE 598
            .|.|  .||.||:..|: .||.||..|   ||:      ..|..::.|::|.           .|
  Fly  5121 PPNE--EEIEAENVDELMEAEEPAVDPEDDAELEQLGAEKTEQKSDKPSKTEKSKEQLETPEGME 5183

  Fly   599 IPADVPAQVVAEAPAETPAETPAEVPAEIPSKVQDEIQSDSTQAEPQVEKE-----AQQPEK--- 655
            |..:|...:.....:||.|.:.:|:..:..|..:|...::..:...|.:|:     ..|||.
  Fly  5184 IEGEVVLTMTVPRSSETTAHSNSEILLDKSSHAEDLSSAEQIELRQQYQKQLTTFRVAQPEHEDY 5248

  Fly   656 ETKPLESSLLTTIIPMVMPQPQVPSQPLQV--------------QDSVLNYVNASFMQQQPSETD 706
            ||....|:.:|.....:..|.::..:|.:.              ...::.|:.:.|.:.:
  Fly  5249 ETWQGISNRMTQNARELCEQLRLILEPTKCTRLKGDYRTGRRINMKKIIPYIASQFRKDK----- 5308

  Fly   707 LPKTEEESPFNAHLRRYDGAQ-VWRIVVQTDKDKRMADELQSKYDGQLWKEVKQEVDYLLKPQVL 770
                       ..|||...|| .::|.:..|..|.|.....        |.:..|...|:. |.|
  Fly  5309 -----------IWLRRTKPAQRDYKITIAIDDSKSMHHNNS--------KTLTLEAISLVS-QAL 5353

  Fly   771 AAAERHIRAANLSRIVLIDNLQRVIEKENPPAEKIAELQNRKGHRLTWQAYHRLED---IHGFID 832
            ...|    :..|| ||......::|         :...:...|.||. .|.:..:|   |.|.::
  Fly  5354 TLLE----SGRLS-IVSFGEAPQII---------LNHTEQFDGPRLV-NALNFAQDKTKIAGLLN 5403

  Fly   833 YMAKTYPDICSTEIIGYSVEKRPLKILKISNGNARNPGIWIDGGMHAREWISPATVTYIANQLVE 897
            ::.     ..:.|..|...:....:.|.:...:.||  |:.:|..:.:..|..|.:..|.  ||.
  Fly  5404 FIR-----TANAEESGTGGDNGLFENLLLILSDGRN--IFSEGAQNVKNAIKLARLQRIF--LVY 5459

  Fly   898 GWEDLPEHMRSINWYIHPVANPDG 921
            ...|.|::..||....|...|.||
  Fly  5460 IIIDNPDNKNSILDIQHVAVNADG 5483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3108	NP_572262.1	Propep_M14	730..797	CDD:280416	15/66 (23%)
CG3108	NP_572262.1	M14_CP_A-B_like	821..1112	CDD:199844	23/104 (22%)
CG13185	NP_001097279.2	MDN1	298..5521	CDD:227596	223/1064 (21%)
		P-loop_NTPase	315..505	CDD:304359
		P-loop_NTPase	<887..972	CDD:304359
		P-loop_NTPase	1147..1283	CDD:304359
		P-loop_NTPase	1454..1603	CDD:304359
		P-loop_NTPase	1795..1946	CDD:304359
		P-loop_NTPase	<2335..>2378	CDD:304359
		Prothymosin	4843..4920	CDD:281265	19/76 (25%)
		PHA03151	4856..5060	CDD:177546	47/228 (21%)
		MttA_Hcf106	<5046..5166	CDD:294511	34/121 (28%)
		vWA_midasin	5261..5526	CDD:238737	51/272 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910