DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3108 and CG8945

DIOPT Version :9

Sequence 1:	NP_572262.1	Gene:	CG3108 / 31506	FlyBaseID:	FBgn0029807	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster

Alignment Length:	1296	Identity:	269/1296 - (20%)
Similarity:	467/1296 - (36%)	Gaps:	319/1296 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LNQV------ASMSLDRLALERNELPADQQQQQQQDVLVDNMKLTSIPSADSSDMYMLVPDTVAS 90
            ||.|      |...:.||...:|.:.....:..:.:.....:.:||.|....||..:.:|....|
  Fly   215 LNPVHHGGTTARPQIIRLKKPKNPITKPSNKLPKPNYRPPPVMVTSGPIDHVSDQLLKLPHRTGS 279

  Fly    91 QLEDT-----------------EHVNRNSIE---------ADPESDPSGS--------SSSDMLM 121
            ....|                 :.:.:|..:         |:....|.||        .|:....
  Fly   280 TTRSTTTTTSTTSRPNTRRKKRKKIPKNKTKVIKKRPGYGANNTRGPQGSLPIILGKRPSTTTTT 344

  Fly   122 LESDSSPAMQLVELP--SDITVAESQPETEHDTEND---QQQPESIEEHVVLMKPASQEAQLEQT 181
            ..|...||...:|.|  ...|:..|...::|...:|   .::.|::||...|........::.::
  Fly   345 TTSRPPPAYTQLEKPHMPQATLPTSNVFSQHLLRSDLEPAEESETLEEQEPLQSDEQLNLRIRRS 409

  Fly   182 V-DLATEAAPVPLNDELPEDEESPAATESAVEELEKESEAAMDDQVPEESEIQPEQ-------VQ 238
            | |:..|....||:.:...........:|.::...|.:....:....:.|..|..:       ::
  Fly   410 VEDVRREKRRGPLHAKKRNSSLKALIKKSVLKNAVKRARLLKNQGEMDSSRTQHRRSRRSLYSIK 474

  Fly   239 PGEYQSESDGEQAETKPEIEAQPEVEAQPEAEAQ----PEAEPQLEVEPQPEVESQPEVESQPEV 299
            .||.:.....|:|...|..||:.||.|.....:|    .|::..|.       ...|.|.:...|
  Fly   475 NGEIEKSIKTEKATKVPSEEAEKEVTADSTKRSQKVVSKESKTILS-------RGNPNVVAARRV 532

  Fly   300 EAQPEVEPQSEVESQPEAESHSEPETQAEVEAQPEVESLPEA-------ESQPEAESQPEREPEV 357
            .......|:.. ..:.:.:..:.|.||.:.:....|..:|.|       .||.|....|....:.
  Fly   533 STPKRRSPKGS-SGRRKTKQQTPPSTQKKEKNSGGVLHIPTALHLLHRNHSQDEVPKVPLNANQK 596

  Fly   358 EAEKISDNEVDTTEASLMETLVEGIEDGLTAAMDNLVPEELAEASDKQ----ETELESEDQQSPV 418
            :..|:.:.:....:....: :.|.:.||   ..::...||..|..|.:    |.|.:.||:..|
  Fly   597 KKRKVKERKRGRPQLPSFD-IFELMSDG---DYEDEGEEEEEEQDDDEDYYFEDEHKDEDKNKP- 656

  Fly   419 TEAIEEQAVPEIEQEKEKEPEQ---------ITLADETEQDSAQPSNEE---------------- 458
                .|.:..|:.|...||...         ..:.:||...:...|:||
  Fly   657 ----NESSSTEVGQSDLKEDSSSAEEGADFGAMVEEETTTTATISSSEELDATSSTKNSMAKKKI 717

  Fly   459 -----PVEIAPEQHTEAE----------------IAPAKIPEE-GKPEEEVQVEEESKPVEE--- 498
                 ||: :.|.:.:.|                :|.:::.:. |.|:||...|..::||.:
  Fly   718 RIKRRPVD-SDEDYDDDEDSGIAGFFRMIFYPVQVAMSRLMDGFGTPDEEEDKEPATQPVSKYPS 781

  Fly   499 -----SKPEEEIKQQEDAKPEEDDQNYAE----------TQPAVTEVKPEETPADIPVEIPAEVP 548
                 |....|...:.|.:..|||::.:.          .|....::....|...:|:..|.:.|
  Fly   782 YTLYHSAHSNEAYAEPDDEDSEDDEDSSSLGSWFGSWFGLQRRTKKIGSTTTTMPVPLPPPTKAP 846

  Fly   549 AEIPAEIPAEVPAEIPAESPAEIAAE------VPAEIPAEIPAEIPAETPAETHAEIPADVPAQV 607
                   |:.:.:.....|..|..||      ..:...:....:....:...|
  Fly   847 -------PSWLESWFGFGSTTEADAEDDYDKWFSSWFDSRPKRKFRRRSTTST------------ 892

  Fly   608 VAEAPAETPAETPAEVPAEIPSKVQDEIQSDSTQAEPQVEKEAQQPEKETKPLESSLLTTIIPMV 672
             :.....|...||:...|::|                                   :||.:.|:.
  Fly   893 -STTSTTTTTHTPSAAAAQVP-----------------------------------ILTIVDPLR 921

  Fly   673 MPQPQV------------------PSQP-LQVQDSVLNYVNASFMQQQPSETDLPKTEEESPFNA 718
            .||..:                  .|.| ||...:.:.....:......|..|:|
  Fly   922 NPQNWIGILAHHIVNSTGSAISTSTSNPLLQALATRMTTRGTTSTTTTTSRPDVP---------- 976

  Fly   719 HLRR--YDGAQVWRIVVQTDKDKRMADELQSKYDGQLWKEVKQE-----VDYLLKPQVLAAAERH 776
              ||  ||..|:||:..|.::..|..:|.:...||...:.:|..     .|.|:.|::|...:..
  Fly   977 --RRISYDKYQIWRLKPQDEEQVRALEEFKKGEDGVKLQWLKGPSLRGLTDVLVPPKMLVDFQGT 1039

  Fly   777 IRAANLSRIVLIDNLQRVIEKENPPAEKIAELQNRKGHR--------LTWQAYHRLEDIHGFIDY 833
            :....::..|||.::.:.|..|   ..|...||..:..:        :||..||..::|..:::.
  Fly  1040 LNYEGIAHEVLIFDVGKAIAYE---LTKEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEIVKYLET 1101

  Fly   834 MAKTYPDICSTEIIGYSVEKRPLKILKISN----GNARNPG------------------IWIDGG 876
            :...:|.:.....||.|.|.|||.::||.:    ..|.|.|                  ::::.|
  Fly  1102 VRMRHPQLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQANAVFVEAG 1166

  Fly   877 MHAREWISPATVTYIANQLV------EGWEDLPEHMRSINWYIHPVANPDGYEYSHTTDRLWRKN 935
            .....||.||..|::..:|:      :..||: |.:|:..|||.||.|||||.|||..||.|:|:
  Fly  1167 AQGLAWIGPAAATWMIAELLRLMKTNKSNEDV-EFIRNTTWYIMPVLNPDGYAYSHEYDRFWKKS 1230

  Fly   936 MRAH----------------------GRQCPGVDLNRNFGYKWGGKGTSASPCSQTYRGSKAFSE 978
            ...|                      .:.|.||||:||:.|.||.:|:|.:||::.|.|...|||
  Fly  1231 RSQHQTPPPSGLLDSAMTWLQQKRGPDKVCYGVDLDRNWLYHWGKRGSSKAPCNEFYAGPAPFSE 1295

  Fly   979 PETFYISKFISGFPRETFQAYLSFHSYGQYILYPWGYDYQLTQDRAD--LDRVARQAGTSITKST 1041
            |||..:|:|:..: |...:.|:|..:|||.|.||...:.....:|.|  ||  ....||...:..
  Fly  1296 PETKAVSEFLMDY-RTQIKLYISLQAYGQVISYPVKANSTFNSERLDDFLD--VAMVGTDGLRKK 1357

  Fly  1042 GVK--YTVGSSATTLYPAAGGSDDWAKGIAGIKYAYTIEMGDTGRYGFVLPARFIQYNGKD 1100
            |.|  |.|.:|...:...:|.:|.:|....||.::||:::.|.|.:|::||:..|:...:|
  Fly  1358 GSKSRYKVDASNDLIEQRSGCADAFAAYEIGIPFSYTLQLADNGVHGYLLPSSAIEPTARD 1418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3108	NP_572262.1	Propep_M14	730..797	CDD:280416	15/71 (21%)
CG3108	NP_572262.1	M14_CP_A-B_like	821..1112	CDD:199844	103/334 (31%)
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	14/69 (20%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	103/334 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920