DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3108 and sftb-1

DIOPT Version :9

Sequence 1:	NP_572262.1	Gene:	CG3108 / 31506	FlyBaseID:	FBgn0029807	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	NP_497853.1	Gene:	sftb-1 / 175549	WormBaseID:	WBGene00011605	Length:	1322	Species:	Caenorhabditis elegans

Alignment Length:	828	Identity:	152/828 - (18%)
Similarity:	263/828 - (31%)	Gaps:	281/828 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 EPQPEVESQPEVESQPEVEAQP-----EVEPQSEVESQPEAESHSEPETQAEVEAQPEVESLPEA 341
            |...:.:|.|.|:.:....|||     ||...|| ::.|.|::    .|:...|.|.:..
Worm    71 EDDVDEDSMPSVQKKSTNYAQPHKFIEEVAAASE-DTDPFADT----RTKTIAERQSKYH----- 125

  Fly   342 ESQPEAESQPEREPEVEAEKISDNEVDTTEASLMETLVEGIEDGLTAAMDNLVPEELAEASDKQE 406
            |.....:..|:|         :|..||.|..:......|.:.|.:.......|..|||:.:...|
Worm   126 ERAMRRQISPDR---------ADAFVDQTPDNRNRGYAEVMRDQMYHEEKGRVERELADRAKAGE 181

  Fly   407 TELESE--------DQQSPVTEAIEE-----QAVPEIEQEKEKEPEQITLADETEQDSAQPS--- 455
            ..:..:        |.::|.|:|..:     .|.|    .:...|.:.....:...|:|.|.
Worm   182 LHVTGQPEKKKGRWDAEAPSTDASSDNLGAASATP----SQGSAPRKRLGFSKISADAATPRAAR 242

  Fly   456 -NEEP------VEIAPEQHTEAEIAPAKIPEEGKPEEEVQVEEESKPVEESKPEEEIK------- 506
             :|.|      .:..|.....:....|:.|...:.:|              .|:|.:.
Worm   243 WDETPAHSTGAADATPSVDKWSTTPAAQTPRRNRWDE--------------TPKENLNDGSMTPG 293

  Fly   507 --QQEDAKPEEDDQNYAETQPAVTEVKPEETPA--------DIPVEIPAEVPAEIPAEIPAEVPA 561
              .:..|:...||            ||.|:||:        |:               .|::.|
Worm   294 WGMETPARGGSDD------------VKIEDTPSASKRRSRWDL---------------TPSQTP- 330

  Fly   562 EIPAESPAEIAAEVPAEIPAEIPAEIPAETPAETHAEIPADVPAQVVAEAPAETPAETPAEVPAE 626
            .:.|.:|.....:.|:..|:.     |::||      |.|..|........|....:|||  |..
Worm   331 NVAAATPLHSGLQTPSFTPSH-----PSQTP------IGAMTPGGATPIGTAAMGMKTPA--PHM 382

  Fly   627 IPSKVQDEIQSDSTQAEPQVEKEAQQPEKETKPLESSLLTTIIP--------------------- 670
            ||          .|..:.|:.:..::.:...:||....|.::.|
Worm   383 IP----------MTPEQMQIYRWEKEIDDRNRPLTDEELDSLFPPGYKVLVPPMNYIPLRTPSRK 437

  Fly   671 -MVMPQPQ---------VPSQPLQVQDSVLNYVNASFMQQQPSETDLP--KTEEESPFNAHLRRY 723
             |..|.|.         :|..|  .:|.:........:..||...:||  |.::...|:..|...
Worm   438 LMATPTPMGGAAGGGFFMPGTP--DRDGIGEKGVGGLVDTQPKNAELPPLKPDDMQYFDKLLMDV 500

  Fly   724 DGAQVWRIVVQTDKDK------------------------RMADELQSKYD-GQLWKEVKQEVDY 763
            |.:|:      |.::|                        |...|...||. |.|:.::   :..
Worm   501 DESQL------TKEEKNEREIMEHLLKIKNGTPPMRKSGLRKITENARKYGAGPLFNQI---LPL 556

  Fly   764 LLKPQVLAAAERHIRAANLSRIVL-IDNLQR--------VIEKENPPAEKIAELQNRKGHRLTWQ 819
            |:.|. |...|||:....:.||:. :|:|.|        |||......:..|.::.|       :
Worm   557 LMSPS-LEDQERHLMVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGR-------E 613

  Fly   820 AYHRLEDIHGFIDYMAKTYPDICSTEIIGYSVEKRPLKILKISNG------------------NA 866
            ....|....|....::...|||.:.:....:...|...::..:.|                  .|
Worm   614 IISNLAKAAGLATMISTMRPDIDNVDEYVRNTTARAFAVVASALGIPALLPFLKAVCKSKKSWQA 678

  Fly   867 RNPGIWIDGGM----------HAREWISPATVTYIANQLVE-GWEDLPEHMRSINWY----IHPV 916
            |:.||.|...|          |.:..:          .:|| |.:|..:.:|:|...    :...
Worm   679 RHTGIKIVQQMAILMGCAVLPHLKALV----------DIVESGLDDEQQKVRTITALCLAALAEA 733

  Fly   917 ANPDGYE-YSHTTDRLWRKNMRAHGRQCPGVDLNRNFGYKWGGKGTSA 963
            ::|.|.| :......||:           |:.::|       |||.:|
Worm   734 SSPYGIEAFDSVLKPLWK-----------GIRMHR-------GKGLAA 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3108	NP_572262.1	Propep_M14	730..797	CDD:280416	21/100 (21%)
CG3108	NP_572262.1	M14_CP_A-B_like	821..1112	CDD:199844	31/177 (18%)
sftb-1	NP_497853.1	DUF5585	185..477	CDD:375359	58/362 (16%)
		SF3b1	316..444	CDD:370189	28/166 (17%)
		HSH155	480..1319	CDD:227508	62/329 (19%)
		HEAT repeat	624..652	CDD:293787	4/27 (15%)
		HEAT repeat	662..691	CDD:293787	6/28 (21%)
		HEAT repeat	868..892	CDD:293787
		HEAT repeat	906..937	CDD:293787
		HEAT repeat	949..979	CDD:293787
		HEAT repeat	991..1017	CDD:293787
		HEAT repeat	1031..1060	CDD:293787
		HEAT repeat	1072..1105	CDD:293787
		HEAT repeat	1114..1136	CDD:293787
		HEAT repeat	1145..1172	CDD:293787
		HEAT repeat	1186..1212	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910