DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3108 and AgaP_AGAP000539

DIOPT Version :9

Sequence 1:	NP_572262.1	Gene:	CG3108 / 31506	FlyBaseID:	FBgn0029807	Length:	1132	Species:	Drosophila melanogaster
Sequence 2:	XP_310544.5	Gene:	AgaP_AGAP000539 / 1271699	VectorBaseID:	AGAP000539	Length:	1266	Species:	Anopheles gambiae

Alignment Length:	1264	Identity:	295/1264 - (23%)
Similarity:	461/1264 - (36%)	Gaps:	362/1264 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 TSIPSADSSDM------YMLVPDTVASQLEDTEHVNRNSIEADPESDPSGSSSSDMLMLESDS-- 126
            |..|:..:|::      |.....|:.:.|.:|........:..|.:.||....:.:..|:|.|
Mosquito   120 TRAPATSASNVTKNSVQYFDDQSTIKNTLNNTNLAYFGDYQLPPATPPSTGVGATVPQLQSFSTT 184

  Fly   127 -----------------SPAMQLVEL------PSDITVAESQPETEHDTENDQQQPESIEEHVVL 168
                             :||:....|      .:|:|.|:..|||..                :|
Mosquito   185 RTPTGPSRRRRKKKPTPAPALPAAALGVSGPTTADLTKAQLTPETLS----------------LL 233

  Fly   169 MKPASQEAQLEQTVDLATEAAPVPLNDELPEDEESPAATESAVEELEKESEAAMDDQVPEESEIQ 233
            .:..|....|.....:.:.|.|.|    ||..:.:...|::  ..|..:..|....:.|:.:.:
Mosquito   234 SRYYSFSCTLTPVQPMPSTATPTP----LPPVQSTTRRTKT--RYLTTKPTAKTTTKRPQTTTV- 291

  Fly   234 PEQVQPGEYQSESDGEQAETKPEIEAQPEV----------------EAQPEAEAQPEAEP--QLE 280
            |..|:             :.||.:..:|.|                .|....|...::|.  ..:
Mosquito   292 PTNVK-------------QRKPVVYVEPPVIKRIGGVLESVYTFMENALTSTEYVEDSEETRAAK 343

  Fly   281 VEPQPEVESQPEVE---------SQPEVEAQPEVEPQSEVES-QPEAESHSEPETQAEVEAQP-- 333
            |.|..:..:.|:|:         |:|:..|....|..|...| .|.|:....|...:|..|.|
Mosquito   344 VRPLRDASASPKVKRNTYTKVSASEPDFVASNSGEGDSASRSTAPGADQTWLPLASSEGAAPPVT 408

  Fly   334 --------EVESLPEAESQPEAESQPEREPEVEAEKISDNEVDTTEASLMETLVEGIEDGLTAAM 390
                    .:..||...|           .:....|::.|...|:|              .|||.
Mosquito   409 KHFTPKLVTISGLPSTIS-----------TDGNKNKMTTNIQVTSE--------------YTAAT 448

  Fly   391 DNLV----PEELAEASDKQETELESEDQQSPVTEAIEEQAVPEIEQEKEKEPE------------ 439
            ...|    |...|.:::..:...|||::......|.||....:.|:|.|::.|
Mosquito   449 PPTVTLGRPTPDASSAEYDDDSSESEEEYFEDFGAFEETDDEDDEEEDEEDDENGEQYGGGSSES 513

  Fly   440 -----QITLADETEQDSAQPSNEEPVEIAPEQHTEAEIAPAKI---------PEEGKPEEEVQVE 490
                 |..|:::.:.:.|....|.||.|...:....:..||..         .|:...|.:.:.|
Mosquito   514 VRPNRQTALSNDKDYEEAGTHVERPVRIKRVKKRRRKKRPAVTSYEDTAEYSDEDSSDEADDEYE 578

  Fly   491 EESKPV-EESKPEEEIKQQED---------------------------AKPEEDD-QNYA---ET 523
            |..:.| |:...||:.:..|.                           |:...|| :.|.   .|
Mosquito   579 ERDESVGEDDDDEEDYESGESPDGAEGFFSRMFSTFGRFVRSLGFGGAARGSPDDYEEYGGARST 643

  Fly   524 QPAVTEV--KPEETPADIPVEIPAEVPAEIPAEIPAEVPAEIPAESPAEIAAEVPAEIPAEIPAE 586
            .|.|..|  :|..:.||:|....|||              :.|..||........|.:..|:..|
Mosquito   644 TPRVQGVRRRPTRSTADVPDYPGAEV--------------QTPERSPVAWLGLPGAYLTNELEEE 694

  Fly   587 IPAETPAETHAEIPADVPAQVVAEAPAETPAETPAEVPAEIPSKVQDEIQSDSTQAEPQVEKEAQ 651
            ..|.||.               .|.|.|....:.......:|....:...||.:..:..:
Mosquito   695 EVAPTPE---------------LELPVEPSPTSSGWFDVMMPWDFFNPWTSDESTDQEVI----- 739

  Fly   652 QPEKETKPLESSLLTTIIPMVMPQPQV-----PSQPLQVQDSVLNYVNASFMQQQPSETDLPKTE 711
             ||.:|           :|.|.| |||     ||.|:....|.. :..||.....||.|.|||.|
Mosquito   740 -PEAQT-----------VPAVTP-PQVVVTPSPSAPISGWLSQF-FGTASTTTPPPSTTTLPKPE 790

  Fly   712 E---------------ESPFNAHLRR-------YDGAQVWRIVVQTDKDKRMADELQSKYDG--- 751
            :               :.|..|...:       |...|:|||..||.:..:..::.:...||
Mosquito   791 QILSVLAQYVAQSATTKRPLAAAPSKRPSRTVSYANYQLWRIFAQTAEQLQRLEDYRQSPDGLRL 855

  Fly   752 QLW--KEVKQEVDYLLKPQVLAAAER-HIRAANLSRIVLIDNLQRVIEKENPP---AEKIAELQN 810
            |.|  ..:.:..|.|:.|..||.:.| ::....|.....|.::.:.|..|||.   .|:: ||:.
Mosquito   856 QWWTHPSLHRPTDVLVPPGALADSLREYLDEEALRHEPTIRDVGQAIAYENPAMTRREQL-ELEL 919

  Fly   811 RKGHRLTWQAYHRLEDIHGFIDYMAKTYPDICSTEIIGYSVEKRPLKILKIS--NGNAR------ 867
            .:||.|||..|||..||..|:.::.:.:|:......||.|.|.||:.:.::|  :|..|
Mosquito   920 HQGHPLTWYRYHRYADIVKFLYHLQRRHPEQVQLLHIGRSYEGRPITVARVSFHSGPKRPKRAKK 984

  Fly   868 NPGIWIDGGMHAREWISPATVTYIANQLVE--------GWEDLPEHMRSI---NWYIHPVANPDG 921
            .|.::::.|.|..|||.|:..|::.::|:|        |..  ||..|:|   :||:.||.||||
Mosquito   985 RPAVFVEAGAHGHEWIGPSVATWLLHRLLELPQAEPSNGTS--PEEARTIQSYDWYVLPVLNPDG 1047

  Fly   922 YEYSHTTDRLWRKNMRAH---------------------------GRQCPGVDLNRNFGYKWGGK 959
            |||||..||||.||...|                           |..|.|||||||:.|:| .:
Mosquito  1048 YEYSHRYDRLWSKNRSNHTQAHPAGVGQALLSSAISWWNADKDPTGEGCYGVDLNRNWAYRW-AQ 1111

  Fly   960 GTSASPCSQTYRGSKAFSEPETFYISKFISGFPRETFQAYLSFHSYGQYILY---------PWGY 1015
            ......||..|.|::.||||||..:..|:.. .|...:.|||..:|||.:.|         |:|.
Mosquito  1112 AVHPGQCSDNYAGAEPFSEPETRAVRDFLLA-RRRHVRLYLSLQAYGQLLAYPELERADDPPYGP 1175

  Fly  1016 D-----YQLTQDRADLDRVARQAGT---SITKSTGVKYTVGSSATTLYPAA-GGSDDWAKGIAGI 1071
            |     :::.|  |.||.:..:.|.   ::...||             ||. |.:..:|:..|||
Mosquito  1176 DPPGDVHEMGQ--AGLDALRAEPGEFLYALEPVTG-------------PATYGTATGYARYGAGI 1225

  Fly  1072 KYAYTIEMGDTGRYGFVLPARFIQYNGKD 1100
            :|:||:.:.|.|.:||:||...|...|:|
Mosquito  1226 RYSYTLRLPDRGTHGFLLPPSSIVPIGRD 1254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3108	NP_572262.1	Propep_M14	730..797	CDD:280416	17/72 (24%)
CG3108	NP_572262.1	M14_CP_A-B_like	821..1112	CDD:199844	110/344 (32%)
AgaP_AGAP000539	XP_310544.5	Propep_M14	831..902	CDD:280416	16/70 (23%)
AgaP_AGAP000539	XP_310544.5	M14_CP_A-B_like	930..1265	CDD:199844	110/344 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820