DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42264 and cpa1

DIOPT Version :9

Sequence 1:	NP_572260.2	Gene:	CG42264 / 31504	FlyBaseID:	FBgn0259149	Length:	634	Species:	Drosophila melanogaster
Sequence 2:	NP_001018318.1	Gene:	cpa1 / 325886	ZFINID:	ZDB-GENE-050522-438	Length:	418	Species:	Danio rerio

Alignment Length:	507	Identity:	129/507 - (25%)
Similarity:	216/507 - (42%)	Gaps:	103/507 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 LTFVALIGSVFGQKLLLWRSVSVPEISGISGLPLALLTLNSSELYESTLEGLQ-WLSPMDLRRFD 197
            |...||..:|||:  :.:....|..|:..:...::||    .||.|:.|.||. |::|
Zfish     5 LVLTALFVAVFGK--VTFEGDQVLRINAKNAEQISLL----KELTEADLLGLDFWMNP------- 56

  Fly   198 FISPGSSYQINRRYRNGSQVQRYYGFQLWKVHETRLEQPELRAFWRHFGSEVWNINQDGIDILIE 262
                                             .|...|                    :|:.:.
Zfish    57 ---------------------------------ARESLP--------------------VDLHVP 68

  Fly   263 QRNVADARKFMDKVGYSYNIMIDDIESAIDESYVEVPAVEHPLDSVRNNSLPWMEVPGSTMN--W 325
            ..::...|.|:......|:|||::::..:|:..:::              |.:...|.||.:  :
Zfish    69 FHSLQAVRAFLAYNQIPYHIMIENVQDLVDKEQLQM--------------LKYHGFPRSTDDFVY 119

  Fly   326 RRYHDQADIKQFLQTLLETYSENVELIQIGVTRNKRPLEVIRVSNG--NPDNWAVFVDAGLQARD 388
            ..|||...|..|:..|:......|..|:||.:...|||.|::.|.|  .|..|   :|.||.:|:
Zfish   120 TTYHDLDSINLFMDMLVAENQNMVSKIEIGQSYENRPLNVLKFSTGANRPGIW---IDTGLHSRE 181

  Fly   389 WLSPAALTYAISKLTHLWGR-PKGKDKGEGQRQSRAEKAMRRIDWYFLPLANPDGYQYSRQTDRL 452
            |::.|:..:...|:...:|| |...|            .:...|.:...:|||||..|:...||:
Zfish   182 WITHASGIWFAKKIVTDYGRDPVLTD------------ILNSYDIFLEIVANPDGLAYTHSDDRM 234

  Fly   453 WTKNRGYDSVSGCYGVNLDRNFDYGWDGTGSTSNPCKNLYRGAHSFSEPESRAVCSFLSGMREYL 517
            |.|.|..:..|.|.||:.:||::.|:.|.||:||||...|.|....||||.:|:..|:.. ...|
Zfish   235 WRKTRKPNPGSSCVGVDPNRNWETGFGGPGSSSNPCSQTYHGPSIHSEPEVKAIVEFVKS-HGNL 298

  Fly   518 GAYVSLGGYGQAITYPWGDADYVTENQRNLKQTARRAVLALRRLNQAEYSSGTSYRQKLARPGNS 582
            .|::|:..|.|.:.||:|......::|..|.:.||:|...|:.|....|:.|:.........|.:
Zfish   299 KAFLSIHSYSQMLLYPYGYTQTAAKDQAELHELARKATSELQSLYNTAYTYGSIITTIYQADGVT 363

  Fly   583 ADWVQDRIGPQLVFNMFLKDQGRYGYLLPPHYIVESGEEVFEFLRIIAQQLQ 634
            .||..:: |.:..:...|:|.||||::||...|:.:.||.:..|.:|.:.::
Zfish   364 TDWAYEQ-GIKYSYTFELRDTGRYGFILPADQILPTAEETWLALMVIMEHIK 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42264	NP_572260.2	Propep_M14	<241..293	CDD:280416	7/51 (14%)
CG42264	NP_572260.2	M14_CP_A-B_like	328..633	CDD:199844	97/307 (32%)
cpa1	NP_001018318.1	Propep_M14	27..99	CDD:280416	20/135 (15%)
cpa1	NP_001018318.1	Peptidase_M14_like	117..416	CDD:299699	97/315 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593527
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750